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- Cytotoxic_necrotising_factor_family abstract "In molecular biology, the cytotoxic necrotising factor family of proteins includes bacterial cytotoxic necrotising factor proteins and the related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) is a toxin whose structure from Escherichia coli revealed a 4-layer alpha/beta/beta/alpha structure containing mixed beta-sheets. CNF1 is expressed in strains of E. coli causing uropathogenic and neonatal meningitis. CNF1 alters host cell actin cytoskeleton and promotes bacterial invasion of the blood–brain barrier endothelial cells. CNF1 belongs to a unique group of large cytotoxins that cause constitutive activation of Rho guanosine triphosphatases (GTPases), which are key regulators of the actin cytoskeleton .Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain.".
- Cytotoxic_necrotising_factor_family symbol "CNF1".
- Cytotoxic_necrotising_factor_family thumbnail PDB_1hzg_EBI.jpg?width=300.
- Cytotoxic_necrotising_factor_family wikiPageID "32272227".
- Cytotoxic_necrotising_factor_family wikiPageLength "2915".
- Cytotoxic_necrotising_factor_family wikiPageOutDegree "29".
- Cytotoxic_necrotising_factor_family wikiPageRevisionID "677944366".
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Actin.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Bacteria.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Bacterial.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Beta-sheet.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Beta_sheet.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Biomolecular_structure.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Blood–brain_barrier.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Bordetella.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Category:Protein_domains.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Cell_(biology).
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Cytoskeleton.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Cytotoxic.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Cytotoxicity.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Cytotoxins.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Deamidation.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Endothelial_cell.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Endothelium.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Enzyme.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Escherichia_coli.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Focal_adhesion.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Gene_activation.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Gene_expression.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Guanosine.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Infant.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Meningitis.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Necrosis.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Necrotizing.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Neonatal.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Protein.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Protein_domain.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Proteins.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink RHOA.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Regulation_of_gene_expression.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Secondary_structure.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Species.
- Cytotoxic_necrotising_factor_family wikiPageWikiLink Toxin.
- Cytotoxic_necrotising_factor_family wikiPageWikiLinkText "Cytotoxic necrotising factor family".
- Cytotoxic_necrotising_factor_family wikiPageWikiLinkText "dermonecrotic factor".
- Cytotoxic_necrotising_factor_family caption "866.0".
- Cytotoxic_necrotising_factor_family hasPhotoCollection Cytotoxic_necrotising_factor_family.
- Cytotoxic_necrotising_factor_family interpro "IPR008430".
- Cytotoxic_necrotising_factor_family name "CNF1".
- Cytotoxic_necrotising_factor_family pfam "PF05785".
- Cytotoxic_necrotising_factor_family scop "1".
- Cytotoxic_necrotising_factor_family symbol "CNF1".
- Cytotoxic_necrotising_factor_family wikiPageUsesTemplate Template:Infobox_protein_family.
- Cytotoxic_necrotising_factor_family wikiPageUsesTemplate Template:InterPro_content.
- Cytotoxic_necrotising_factor_family wikiPageUsesTemplate Template:Reflist.
- Cytotoxic_necrotising_factor_family subject Category:Protein_domains.
- Cytotoxic_necrotising_factor_family type Biomolecule.
- Cytotoxic_necrotising_factor_family type Protein.
- Cytotoxic_necrotising_factor_family type Chemical.
- Cytotoxic_necrotising_factor_family type Domain.
- Cytotoxic_necrotising_factor_family type Thing.
- Cytotoxic_necrotising_factor_family type Q206229.
- Cytotoxic_necrotising_factor_family type Q8054.
- Cytotoxic_necrotising_factor_family comment "In molecular biology, the cytotoxic necrotising factor family of proteins includes bacterial cytotoxic necrotising factor proteins and the related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) is a toxin whose structure from Escherichia coli revealed a 4-layer alpha/beta/beta/alpha structure containing mixed beta-sheets. CNF1 is expressed in strains of E. coli causing uropathogenic and neonatal meningitis.".
- Cytotoxic_necrotising_factor_family label "Cytotoxic necrotising factor family".
- Cytotoxic_necrotising_factor_family sameAs m.0gxyxfc.
- Cytotoxic_necrotising_factor_family sameAs Q5201401.
- Cytotoxic_necrotising_factor_family sameAs Q5201401.
- Cytotoxic_necrotising_factor_family wasDerivedFrom Cytotoxic_necrotising_factor_family?oldid=677944366.
- Cytotoxic_necrotising_factor_family depiction PDB_1hzg_EBI.jpg.
- Cytotoxic_necrotising_factor_family isPrimaryTopicOf Cytotoxic_necrotising_factor_family.