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- CytRx abstract "CytRx Corp. (NASDAQ: CYTR) is a biopharmaceutical research and development oncology company based in Los Angeles, California.The CytRx oncology pipeline includes six clinical trials involving their lead drug aldoxorubicin. Aldoxorubicin (formerly INNO-206) is a modified form of doxorubicin, the popular anthracycline chemotherapeutic agent known as "red death".Doxorubicin. Anthracyclines are a class of drugs that are among the most commonly used agents in the treatment of cancer. Doxorubicin, the first anthracycline to gain approval, has demonstrated efficacy in a wide variety of cancers including breast cancer, lung cancer, sarcomas, and lymphomas. However, doxorubicin is associated with side effects such as myelosuppression, gastrointestinal disorders, mucositis, stomatitis, cumulative cardiotoxicity and extravasation.Aldoxorubicin is a tumor-targeted doxorubicin conjugate. Specifically, it is the (6-Maleimidocaproyl) hydrazone of doxorubicin. Essentially, this chemical name describes doxorubicin (DOXO) attached to an acid sensitive linker (EMCH). Completed preclinical and clinical trials (see below) indicate that this novel agent has attributes that improve on native doxorubicin including reduction of adverse events, improvement in efficacy and the ability to reach the tumor more quickly. CytRx holds the exclusive worldwide rights to aldoxorubicin.The proposed mechanism of action is as follows:1) After administration, aldoxorubicin rapidly binds endogenous circulating albumin through the EMCH linker2) Circulating albumin preferentially accumulates in tumors, bypassing uptake by other non-specific sites including heart, bone marrow and gastrointestinal tract3) Once albumin-bound aldoxorubicin reaches the tumor, the acidic environment of the tumor causes cleavage of the acid sensitive linker4) Free doxorubicin is released at the site of the tumorThe six clinical trials are as follows (additional information can be found at the government web site clinical trials dot com):1) Study to Investigate the Safety and Activity of Aldoxorubicin Plus Gemcitabine in Subjects With Metastatic Solid Tumors2 )Study to Investigate the Safety and Activity of Aldoxorubicin Plus Ifosfamide/Mesna in Subjects With Metastatic Soft Tissue Sarcoma 3 )Phase 2 Study to Investigate the Efficacy and Safety of Aldoxorubicin in Subjects With Glioblastoma 4) A Study to Investigate ALDOXORUBICIN in HIV-infected Subjects With Kaposi's Sarcoma 5) Efficacy and Safety of Aldoxorubicin Compared to Topotecan in Subjects With Metastatic Small Cell Lung Cancer 6) Phase 3 Study to Treat Patients With Soft Tissue SarcomasIn addition, CytRx has completed a global Phase 2b clinical trial with aldoxorubicin as a first-line therapy for soft tissue sarcomas, a Phase 1b/2 clinical trial primarily in the same indication, a Phase 1b clinical trial of aldoxorubicin in combination with doxorubicin in patients with advanced solid tumors and a Phase 1b pharmacokinetics clinical trial in patients with metastatic solid tumors. CytRx plans to expand its pipeline of oncology candidates at its laboratory facilities in Freiburg, Germany, based on novel linker technologies that can be utilized with multiple chemotherapeutic agents and may allow for greater concentration of drug at tumor sites.The corporate website is http://www.cytrx.com/aldoxorubicinSteven Arthur Kriegsman is the President and CEO.".
- CytRx wikiPageExternalLink 2756043-behind-the-short-are-investors-of-cytrx-that-shallow.
- CytRx wikiPageExternalLink www.cytrx.com.
- CytRx wikiPageExternalLink aldoxorubicin.
- CytRx wikiPageID "5605714".
- CytRx wikiPageLength "6511".
- CytRx wikiPageOutDegree "17".
- CytRx wikiPageRevisionID "666535882".
- CytRx wikiPageWikiLink Biopharmaceutical.
- CytRx wikiPageWikiLink CNNMoney.
- CytRx wikiPageWikiLink California.
- CytRx wikiPageWikiLink Category:Companies_based_in_Los_Angeles,_California.
- CytRx wikiPageWikiLink Category:Companies_listed_on_NASDAQ.
- CytRx wikiPageWikiLink Category:Pharmaceutical_companies_of_the_United_States.
- CytRx wikiPageWikiLink Conflict_of_interest.
- CytRx wikiPageWikiLink Doxorubicin.
- CytRx wikiPageWikiLink DreamTeamGroup.
- CytRx wikiPageWikiLink Forbes.
- CytRx wikiPageWikiLink Forbes.com.
- CytRx wikiPageWikiLink Galena_Biopharma.
- CytRx wikiPageWikiLink Los_Angeles.
- CytRx wikiPageWikiLink Motley_Fool.
- CytRx wikiPageWikiLink Research_and_development.
- CytRx wikiPageWikiLink Seeking_Alpha.
- CytRx wikiPageWikiLink Steven_Arthur_Kriegsman.
- CytRx wikiPageWikiLink Stock_promoter.
- CytRx wikiPageWikiLink The_Motley_Fool.
- CytRx wikiPageWikiLinkText "CytRx Corporation".
- CytRx wikiPageWikiLinkText "CytRx".
- CytRx hasPhotoCollection CytRx.
- CytRx wikiPageUsesTemplate Template:NASDAQ.
- CytRx wikiPageUsesTemplate Template:Pharmaceutical_companies_of_the_United_States.
- CytRx wikiPageUsesTemplate Template:Primary_sources.
- CytRx wikiPageUsesTemplate Template:Reflist.
- CytRx wikiPageUsesTemplate Template:US$.
- CytRx subject Category:Companies_based_in_Los_Angeles,_California.
- CytRx subject Category:Companies_listed_on_NASDAQ.
- CytRx subject Category:Pharmaceutical_companies_of_the_United_States.
- CytRx type Article.
- CytRx type Company.
- CytRx type Article.
- CytRx type Company.
- CytRx type Organization.
- CytRx type Organization.
- CytRx comment "CytRx Corp. (NASDAQ: CYTR) is a biopharmaceutical research and development oncology company based in Los Angeles, California.The CytRx oncology pipeline includes six clinical trials involving their lead drug aldoxorubicin. Aldoxorubicin (formerly INNO-206) is a modified form of doxorubicin, the popular anthracycline chemotherapeutic agent known as "red death".Doxorubicin. Anthracyclines are a class of drugs that are among the most commonly used agents in the treatment of cancer.".
- CytRx label "CytRx".
- CytRx sameAs m.0dvxgk.
- CytRx sameAs Q5201295.
- CytRx sameAs Q5201295.
- CytRx wasDerivedFrom CytRx?oldid=666535882.
- CytRx homepage www.cytrx.com.
- CytRx isPrimaryTopicOf CytRx.