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- Cyanovirin-N abstract "Cyanovirin-N (CV-N) is a protein produced by the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (HIV). The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins gp120 and gp41, as well as to high-mannose oligosaccharides found on the HIV envelope. In addition, CV-N is active against rhinoviruses, human parainfluenza virus, respiratory syncytial virus, and enteric viruses. The virucidal activity of CV-N against influenza virus is directed towards viral haemagglutinin. CV-N has a complex fold composed of a duplication of a tandem repeat of two homologous motifs comprising three-stranded beta-sheet and beta-hairpins.Professor Julian Ma of St George's Hospital, South London, has a project in Kent, England to use genetically modified tobacco plants to produce the Cyanovirin and from this produce a cream which could be used to prevent HIV infectionCyanovirin a protein with a highly complicated structure, it binds to sugars attached to HIV,it envelopes the protein and prevents it from binding to the mucosal cell surfaces in the Vagina and Rectum, this compound is also active against herpes viruses."development of cyanovirin has been exceedingly slow-paced. The chief of the NCI cyanovirin program, Michael Boyd, described it as "languishing." Apparently the NCI's production facilities, based on genetically manipulated cell cultures, have been diverted to other projects that the agency considers of higher priority. This is unfortunate: cyanovirin is of particular interest because of its relative safety. It is 10,000 times more toxic to HIV than it is to cells."This protein may use the morpheein model of allosteric regulation.".
- Cyanovirin-N wikiPageExternalLink cyanovirin.htm.
- Cyanovirin-N wikiPageExternalLink 5152172.stm.
- Cyanovirin-N wikiPageID "6155552".
- Cyanovirin-N wikiPageLength "4350".
- Cyanovirin-N wikiPageOutDegree "27".
- Cyanovirin-N wikiPageRevisionID "676133561".
- Cyanovirin-N wikiPageWikiLink Allosteric_regulation.
- Cyanovirin-N wikiPageWikiLink Beta-sheet.
- Cyanovirin-N wikiPageWikiLink Beta_sheet.
- Cyanovirin-N wikiPageWikiLink Category:Antiretroviral_drugs.
- Cyanovirin-N wikiPageWikiLink Category:Proteins.
- Cyanovirin-N wikiPageWikiLink Category:Proteomics.
- Cyanovirin-N wikiPageWikiLink Cyanobacteria.
- Cyanovirin-N wikiPageWikiLink Cyanobacterium.
- Cyanovirin-N wikiPageWikiLink Enteric.
- Cyanovirin-N wikiPageWikiLink Envelope_glycoprotein_GP120.
- Cyanovirin-N wikiPageWikiLink Glycoprotein.
- Cyanovirin-N wikiPageWikiLink Glycoproteins.
- Cyanovirin-N wikiPageWikiLink Gp120.
- Cyanovirin-N wikiPageWikiLink HIV.
- Cyanovirin-N wikiPageWikiLink Haemagglutinin.
- Cyanovirin-N wikiPageWikiLink Hemagglutinin.
- Cyanovirin-N wikiPageWikiLink Homo_sapiens.
- Cyanovirin-N wikiPageWikiLink Homology_(biology).
- Cyanovirin-N wikiPageWikiLink Human_gastrointestinal_tract.
- Cyanovirin-N wikiPageWikiLink Human_immunodeficiency_virus.
- Cyanovirin-N wikiPageWikiLink Human_parainfluenza_viruses.
- Cyanovirin-N wikiPageWikiLink Human_respiratory_syncytial_virus.
- Cyanovirin-N wikiPageWikiLink Influenza_virus.
- Cyanovirin-N wikiPageWikiLink Mannose.
- Cyanovirin-N wikiPageWikiLink Morpheein.
- Cyanovirin-N wikiPageWikiLink Nostoc_ellipsosporum.
- Cyanovirin-N wikiPageWikiLink Oligosaccharide.
- Cyanovirin-N wikiPageWikiLink Orthomyxoviridae.
- Cyanovirin-N wikiPageWikiLink Parainfluenza.
- Cyanovirin-N wikiPageWikiLink Protein.
- Cyanovirin-N wikiPageWikiLink Protein_motif.
- Cyanovirin-N wikiPageWikiLink Respiratory_syncytial_virus.
- Cyanovirin-N wikiPageWikiLink Rhinovirus.
- Cyanovirin-N wikiPageWikiLink Structural_motif.
- Cyanovirin-N wikiPageWikiLink Tandem_repeat.
- Cyanovirin-N wikiPageWikiLink Virucide.
- Cyanovirin-N wikiPageWikiLink Virus.
- Cyanovirin-N wikiPageWikiLinkText "Cyanovirin-N".
- Cyanovirin-N wikiPageWikiLinkText "cyanovirin-N".
- Cyanovirin-N hasPhotoCollection Cyanovirin-N.
- Cyanovirin-N wikiPageUsesTemplate Template:Expert-subject.
- Cyanovirin-N wikiPageUsesTemplate Template:HIVpharm.
- Cyanovirin-N wikiPageUsesTemplate Template:Protein-stub.
- Cyanovirin-N wikiPageUsesTemplate Template:Reflist.
- Cyanovirin-N subject Category:Antiretroviral_drugs.
- Cyanovirin-N subject Category:Proteins.
- Cyanovirin-N subject Category:Proteomics.
- Cyanovirin-N hypernym Protein.
- Cyanovirin-N type Biomolecule.
- Cyanovirin-N type Drug.
- Cyanovirin-N type Protein.
- Cyanovirin-N type Biomolecule.
- Cyanovirin-N type Drug.
- Cyanovirin-N type Nutrient.
- Cyanovirin-N type Omic.
- Cyanovirin-N type Proteomic.
- Cyanovirin-N comment "Cyanovirin-N (CV-N) is a protein produced by the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (HIV). The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins gp120 and gp41, as well as to high-mannose oligosaccharides found on the HIV envelope.".
- Cyanovirin-N label "Cyanovirin-N".
- Cyanovirin-N sameAs m.0ft2t1.
- Cyanovirin-N sameAs Q5197488.
- Cyanovirin-N sameAs Q5197488.
- Cyanovirin-N wasDerivedFrom Cyanovirin-N?oldid=676133561.
- Cyanovirin-N isPrimaryTopicOf Cyanovirin-N.