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- Cutaneous_structure_development abstract "Cutaneous structures arise from the epidermis and include a variety of features such as hair, feathers, claws and nails.During embryogenesis, the epidermis splits into two layers: the periderm (which is lost) and the basal layer. The basal layer is a stem cell layer and through asymmetrical divisions, becomes the source of skin cells throughout life. It is maintained as a stem cell layer through an autocrine signal, TGF-a, and through paracrine signal FGF7 aka keratinocyte growth factor (KGF) produced by the dermis below the basal cells. In mice, over-expression of these factors leads to an overproduction of granule cells and thick skin.Hair and feathers are formed in a regular pattern and it is believed to be the result of a reaction-diffusion system. This reaction-diffusion system combines an activator, Sonic hedgehog, with an inhibitor, BMP4 or BMP2, to form clusters of cells in a regular pattern. Sonic hedgehog-expressing epidermal cells induce the condensation of cells in the mesoderm. The clusters of mesodermal cells signal back to the epidermis to form the appropriate structure for that position. BMP signals from the epidermis inhibit the formation of placodes in nearby ectoderm.It is believed that the mesoderm defines the pattern. The epidermis instructs the mesodermal cells to condense and then the mesoderm instructs the epidermis of what structure to make through a series of reciprocal inductions. Transplantation experiments involving frog and newt epidermis indicated that the mesodermal signals are conserved between species but the epidermal response is species-specific meaning that the mesoderm instructs the epidermis of its position and the epidermis uses this information to make a specific structure.".
- Cutaneous_structure_development wikiPageID "8150057".
- Cutaneous_structure_development wikiPageLength "2061".
- Cutaneous_structure_development wikiPageOutDegree "12".
- Cutaneous_structure_development wikiPageRevisionID "493126981".
- Cutaneous_structure_development wikiPageWikiLink Autocrine.
- Cutaneous_structure_development wikiPageWikiLink Autocrine_signalling.
- Cutaneous_structure_development wikiPageWikiLink Category:Developmental_biology.
- Cutaneous_structure_development wikiPageWikiLink Category:Skin_physiology.
- Cutaneous_structure_development wikiPageWikiLink Epidermis.
- Cutaneous_structure_development wikiPageWikiLink Epidermis_(skin).
- Cutaneous_structure_development wikiPageWikiLink Keratinocyte_growth_factor.
- Cutaneous_structure_development wikiPageWikiLink List_of_cutaneous_conditions.
- Cutaneous_structure_development wikiPageWikiLink Paracrine.
- Cutaneous_structure_development wikiPageWikiLink Paracrine_signalling.
- Cutaneous_structure_development wikiPageWikiLink Reaction-diffusion_system.
- Cutaneous_structure_development wikiPageWikiLink Reaction–diffusion_system.
- Cutaneous_structure_development wikiPageWikiLink Sonic_hedgehog.
- Cutaneous_structure_development wikiPageWikiLink Stem_cell.
- Cutaneous_structure_development wikiPageWikiLink Stratum_basale.
- Cutaneous_structure_development wikiPageWikiLink Stratum_germinativum.
- Cutaneous_structure_development wikiPageWikiLink Transforming_growth_factor.
- Cutaneous_structure_development wikiPageWikiLinkText "Cutaneous structure development".
- Cutaneous_structure_development hasPhotoCollection Cutaneous_structure_development.
- Cutaneous_structure_development wikiPageUsesTemplate Template:Development_of_integument.
- Cutaneous_structure_development wikiPageUsesTemplate Template:Reflist.
- Cutaneous_structure_development wikiPageUsesTemplate Template:Unreferenced.
- Cutaneous_structure_development subject Category:Developmental_biology.
- Cutaneous_structure_development subject Category:Skin_physiology.
- Cutaneous_structure_development type Article.
- Cutaneous_structure_development type Article.
- Cutaneous_structure_development comment "Cutaneous structures arise from the epidermis and include a variety of features such as hair, feathers, claws and nails.During embryogenesis, the epidermis splits into two layers: the periderm (which is lost) and the basal layer. The basal layer is a stem cell layer and through asymmetrical divisions, becomes the source of skin cells throughout life.".
- Cutaneous_structure_development label "Cutaneous structure development".
- Cutaneous_structure_development sameAs m.026tf6p.
- Cutaneous_structure_development sameAs Q5196715.
- Cutaneous_structure_development sameAs Q5196715.
- Cutaneous_structure_development wasDerivedFrom Cutaneous_structure_development?oldid=493126981.
- Cutaneous_structure_development isPrimaryTopicOf Cutaneous_structure_development.