Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Cullin> ?p ?o }
- Cullin abstract "Cullins are a family of hydrophobic proteins providing a scaffold for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes.The human genome contains eight cullin genes CUL1, part of SCF complex CUL2, part of ECS complex (Elongin C - CUL2 - SOCS-box) CUL3, part of CUL3-BTB complex CUL4A CUL4B CUL5 CUL7 CUL9, also known as PARC There is also a more distant member called ANAPC2 (or APC2), part of the Anaphase-promoting complex.CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex.Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as CUL9, also known as p53 cytoplasmic anchor PARC, and the ANAPC2 subunit of the anaphase-promoting complex/cyclosome; both CUL9 and ANAPC2 have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins.With the exception of ANAPC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae (Baker's yeast), and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.".
- Cullin symbol "Cullin".
- Cullin symbol "Cullin_Nedd8".
- Cullin thumbnail PDB_1ldk_EBI.jpg?width=300.
- Cullin wikiPageExternalLink family?id=Cullin.
- Cullin wikiPageID "19209638".
- Cullin wikiPageLength "5780".
- Cullin wikiPageOutDegree "52".
- Cullin wikiPageRevisionID "671863602".
- Cullin wikiPageWikiLink ANAPC2.
- Cullin wikiPageWikiLink Adaptor_protein.
- Cullin wikiPageWikiLink Anaphase-promoting_complex.
- Cullin wikiPageWikiLink Animal.
- Cullin wikiPageWikiLink CUL1.
- Cullin wikiPageWikiLink CUL2.
- Cullin wikiPageWikiLink CUL3.
- Cullin wikiPageWikiLink CUL4A.
- Cullin wikiPageWikiLink CUL4B.
- Cullin wikiPageWikiLink CUL5.
- Cullin wikiPageWikiLink CUL7.
- Cullin wikiPageWikiLink CUL9.
- Cullin wikiPageWikiLink Catalysis.
- Cullin wikiPageWikiLink Catalytic.
- Cullin wikiPageWikiLink Category:Protein_families.
- Cullin wikiPageWikiLink Category:Proteins.
- Cullin wikiPageWikiLink Cell_cycle.
- Cullin wikiPageWikiLink Circadian_rhythm.
- Cullin wikiPageWikiLink Circadian_rhythms.
- Cullin wikiPageWikiLink Conserved_sequence.
- Cullin wikiPageWikiLink Covalent.
- Cullin wikiPageWikiLink Covalent_bond.
- Cullin wikiPageWikiLink Cytoplasm.
- Cullin wikiPageWikiLink DNA_replication.
- Cullin wikiPageWikiLink ECS_complex.
- Cullin wikiPageWikiLink Elongin_C.
- Cullin wikiPageWikiLink Embryogenesis.
- Cullin wikiPageWikiLink Enzyme.
- Cullin wikiPageWikiLink Glucose.
- Cullin wikiPageWikiLink Lysine.
- Cullin wikiPageWikiLink Metazoan.
- Cullin wikiPageWikiLink Multiprotein_complex.
- Cullin wikiPageWikiLink NEDD8.
- Cullin wikiPageWikiLink Neddylation.
- Cullin wikiPageWikiLink P53.
- Cullin wikiPageWikiLink PARC.
- Cullin wikiPageWikiLink Polymer.
- Cullin wikiPageWikiLink Proteasome.
- Cullin wikiPageWikiLink Protein.
- Cullin wikiPageWikiLink Protein-protein_interaction.
- Cullin wikiPageWikiLink Protein_complex.
- Cullin wikiPageWikiLink Proteins.
- Cullin wikiPageWikiLink Protein–protein_interaction.
- Cullin wikiPageWikiLink RING_finger_domain.
- Cullin wikiPageWikiLink Residue_(chemistry).
- Cullin wikiPageWikiLink SCF_complex.
- Cullin wikiPageWikiLink SOCS-box.
- Cullin wikiPageWikiLink Saccharomyces_cerevisiae.
- Cullin wikiPageWikiLink Sanger_Institute.
- Cullin wikiPageWikiLink Scaffold.
- Cullin wikiPageWikiLink Scaffolding.
- Cullin wikiPageWikiLink Signal_transducing_adaptor_protein.
- Cullin wikiPageWikiLink Substrate_(biochemistry).
- Cullin wikiPageWikiLink Substrate_(chemistry).
- Cullin wikiPageWikiLink Ubiquitin.
- Cullin wikiPageWikiLink Ubiquitin_ligase.
- Cullin wikiPageWikiLink Wellcome_Trust_Sanger_Institute.
- Cullin wikiPageWikiLinkText "CRLs".
- Cullin wikiPageWikiLinkText "CULLIN3".
- Cullin wikiPageWikiLinkText "Cullin 3".
- Cullin wikiPageWikiLinkText "Cullin".
- Cullin wikiPageWikiLinkText "cullin".
- Cullin caption "structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex".
- Cullin hasPhotoCollection Cullin.
- Cullin interpro "IPR001373".
- Cullin interpro "IPR019559".
- Cullin name "Cullin protein neddylation domain".
- Cullin name "Cullin".
- Cullin pfam "PF00888".
- Cullin pfam "PF10557".
- Cullin prosite "PDOC00967".
- Cullin scop "1".
- Cullin symbol "Cullin".
- Cullin symbol "Cullin_Nedd8".
- Cullin wikiPageUsesTemplate Template:Cell_cycle_proteins.
- Cullin wikiPageUsesTemplate Template:Infobox_protein_family.
- Cullin wikiPageUsesTemplate Template:InterPro_content.
- Cullin wikiPageUsesTemplate Template:Ligases_CO_CS_and_CN.
- Cullin wikiPageUsesTemplate Template:MeshName.
- Cullin wikiPageUsesTemplate Template:Posttranslational_modification.
- Cullin wikiPageUsesTemplate Template:Protein-stub.
- Cullin wikiPageUsesTemplate Template:Reflist.
- Cullin subject Category:Protein_families.
- Cullin subject Category:Proteins.
- Cullin hypernym Family.
- Cullin type Biomolecule.
- Cullin type Protein.
- Cullin type Biomolecule.
- Cullin type Chemical.
- Cullin type Nutrient.
- Cullin type Thing.