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- Crotonase_family abstract "The crotonase family comprises mechanistically diverse proteins that share a conserved trimeric quaternary structure (sometimes a hexamer consisting of a dimer of trimers), the core of which consists of 4 turns of a (beta/beta/alpha)n superhelix. Some enzymes in the superfamily have been shown to display dehalogenase, hydratase, and isomerase activities, while others have been implicated in carbon-carbon bond formation and cleavage as well as the hydrolysis of thioesters. However, these different enzymes share the need to stabilize an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two structurally conserved peptidic NH groups that provide hydrogen bonds to the carbonyl moieties of the acyl-CoA substrates and form an "oxyanion hole". The CoA thioester derivatives bind in a characteristic hooked shape and a conserved tunnel binds the pantetheine group of CoA, which links the 3'-phosphate ADP binding site to the site of reaction. Enzymes in the crotonase superfamily include: Enoyl-CoA hydratase (crotonase; EC 4.2.1.17), which catalyses the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA. 3-2trans-enoyl-CoA isomerase (or dodecenoyl-CoA isomerise; EC 5.3.3.8), which shifts the 3-double bond of the intermediates of unsaturated fatty acid oxidation to the 2-trans position. 3-hydroxbutyryl-CoA dehydratase (crotonase; EC 4.2.1.55), a bacterial enzyme involved in the butyrate/butanol-producing pathway. 4-Chlorobenzoyl-CoA dehalogenase (EC 3.8.1.6), a Pseudomonas enzyme which catalyses the conversion of 4-chlorobenzoate-CoA to 4-hydroxybenzoate-CoA. Dienoyl-CoA isomerase, which catalyses the isomerisation of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. Naphthoate synthase (MenB, or DHNA synthetase; EC 4.1.3.36), a bacterial enzyme involved in the biosynthesis of menaquinone (vitamin K2). Carnitine racemase (gene caiD), which catalyses the reversible conversion of crotonobetaine to L-carnitine in Escherichia coli. Methylmalonyl CoA decarboxylase (MMCD; EC 4.1.1.41), which has a hexameric structure (dimer of trimers). Carboxymethylproline synthase (CarB), which is involved in carbapenem biosynthesis. 6-oxo camphor hydrolase, which catalyses the desymmetrization of bicyclic beta-diketones to optically active keto acids. The alpha subunit of fatty acid oxidation complex, a multi-enzyme complex that catalyses the last three reactions in the fatty acid beta-oxidation cycle. AUH protein, a bifunctional RNA-binding homologue of enoyl-CoA hydratase.↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑".
- Crotonase_family symbol "ECH".
- Crotonase_family wikiPageID "11470384".
- Crotonase_family wikiPageLength "8925".
- Crotonase_family wikiPageOutDegree "37".
- Crotonase_family wikiPageRevisionID "609977823".
- Crotonase_family wikiPageWikiLink 3-hydroxbutyryl-CoA_dehydratase.
- Crotonase_family wikiPageWikiLink 3-hydroxybutyryl-CoA_dehydrogenase.
- Crotonase_family wikiPageWikiLink 4-Chlorobenzoyl-CoA_dehalogenase.
- Crotonase_family wikiPageWikiLink 4-chlorobenzoyl-CoA_dehalogenase.
- Crotonase_family wikiPageWikiLink 6-oxo_camphor_hydrolase.
- Crotonase_family wikiPageWikiLink AUH_(gene).
- Crotonase_family wikiPageWikiLink AUH_protein.
- Crotonase_family wikiPageWikiLink Acyl-CoA.
- Crotonase_family wikiPageWikiLink CDY2B.
- Crotonase_family wikiPageWikiLink CDYL.
- Crotonase_family wikiPageWikiLink CDYL2.
- Crotonase_family wikiPageWikiLink Carboxymethylproline_synthase.
- Crotonase_family wikiPageWikiLink Carnitine_racemase.
- Crotonase_family wikiPageWikiLink Category:Protein_domains.
- Crotonase_family wikiPageWikiLink Category:Protein_families.
- Crotonase_family wikiPageWikiLink Coenzyme_A.
- Crotonase_family wikiPageWikiLink DCI_(gene).
- Crotonase_family wikiPageWikiLink Dehalogenase.
- Crotonase_family wikiPageWikiLink Dienoyl-CoA_isomerase.
- Crotonase_family wikiPageWikiLink Dodecenoyl-CoA_isomerase.
- Crotonase_family wikiPageWikiLink ECH1.
- Crotonase_family wikiPageWikiLink ECHDC1.
- Crotonase_family wikiPageWikiLink ECHDC2.
- Crotonase_family wikiPageWikiLink ECHDC3.
- Crotonase_family wikiPageWikiLink ECHS1.
- Crotonase_family wikiPageWikiLink EHHADH.
- Crotonase_family wikiPageWikiLink Enol.
- Crotonase_family wikiPageWikiLink Enolate_anion.
- Crotonase_family wikiPageWikiLink Enoyl-CoA_hydratase.
- Crotonase_family wikiPageWikiLink Escherichia_coli.
- Crotonase_family wikiPageWikiLink Fatty_acid_oxidation_complex.
- Crotonase_family wikiPageWikiLink HADHA.
- Crotonase_family wikiPageWikiLink HCA64.
- Crotonase_family wikiPageWikiLink HIBCH.
- Crotonase_family wikiPageWikiLink Hydratase.
- Crotonase_family wikiPageWikiLink Hydration_reaction.
- Crotonase_family wikiPageWikiLink Isomerase.
- Crotonase_family wikiPageWikiLink Methylglutaconyl-CoA_hydratase.
- Crotonase_family wikiPageWikiLink Methylmalonyl-CoA_decarboxylase.
- Crotonase_family wikiPageWikiLink Methylmalonyl_CoA_decarboxylase.
- Crotonase_family wikiPageWikiLink Naphthoate_synthase.
- Crotonase_family wikiPageWikiLink PECI_(gene).
- Crotonase_family wikiPageWikiLink Thioester.
- Crotonase_family wikiPageWikiLinkText "Crotonase family".
- Crotonase_family wikiPageWikiLinkText "crotonase".
- Crotonase_family cdd "cd06558".
- Crotonase_family hasPhotoCollection Crotonase_family.
- Crotonase_family interpro "IPR001753".
- Crotonase_family name "Enoyl-CoA hydratase/isomerase family".
- Crotonase_family pdb "A:48-214 E:48-214 B:48-214 A:48-214 D:90-259 A:18-190 B:18-190 B:18-190 A:10-180 B:116-287 B:48-235 B:48-235 A:48-235 A:48-235 A:67-247 B:22-191 A:11-180 F:11-180 B:15-183 A:15-183 A:20-200 B:20-200 A:20-200 A:20-200 A:295-467 C:27-195 D:27-195 A:45-215 C:58-228".
- Crotonase_family pfam "PF00378".
- Crotonase_family prosite "PDOC00150".
- Crotonase_family scop "1".
- Crotonase_family symbol "ECH".
- Crotonase_family wikiPageUsesTemplate Template:EC_number.
- Crotonase_family wikiPageUsesTemplate Template:InterPro_content.
- Crotonase_family wikiPageUsesTemplate Template:Pfam_box.
- Crotonase_family wikiPageUsesTemplate Template:Reflist.
- Crotonase_family subject Category:Protein_domains.
- Crotonase_family subject Category:Protein_families.
- Crotonase_family type Biomolecule.
- Crotonase_family type Protein.
- Crotonase_family type Domain.
- Crotonase_family type Thing.
- Crotonase_family type Q206229.
- Crotonase_family type Q8054.
- Crotonase_family comment "The crotonase family comprises mechanistically diverse proteins that share a conserved trimeric quaternary structure (sometimes a hexamer consisting of a dimer of trimers), the core of which consists of 4 turns of a (beta/beta/alpha)n superhelix. Some enzymes in the superfamily have been shown to display dehalogenase, hydratase, and isomerase activities, while others have been implicated in carbon-carbon bond formation and cleavage as well as the hydrolysis of thioesters.".
- Crotonase_family label "Crotonase family".
- Crotonase_family sameAs Crotonase.
- Crotonase_family sameAs m.0dlklxd.
- Crotonase_family sameAs Q5188998.
- Crotonase_family sameAs Q5188998.
- Crotonase_family wasDerivedFrom Crotonase_family?oldid=609977823.
- Crotonase_family isPrimaryTopicOf Crotonase_family.