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- Compound_heterozygosity abstract "Compound heterozygosity in medical genetics is the condition of having two heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state. That is, an organism is a compound heterozygote if it has two recessive alleles for the same gene, but with those two alleles being different from each other (for example, both alleles might be mutated but at different locations). Compound heterozygosity reflects the diversity of the mutation base for many autosomal recessive genetic disorders; mutations in most disease-causing genes have arisen many times. This means that many cases of disease arise in individuals who have two unrelated alleles, who technically are heterozygotes, but both the alleles are defective. These disorders are often best known in some classic form, such as the homozygous recessive case of a particular mutation that is widespread in some population. In its compound heterozygous forms, the disease may have lower penetrance, because the mutations involved are often less deleterious in combination than for a homozygous individual with the classic symptoms of the disease. As a result, compound heterozygotes often become ill later in life, with less severe symptoms. Although compound heterozygosity as a cause of genetic disease had been suspected much earlier, widespread confirmation of the phenomenon was not feasible until the 1980s, when polymerase chain reaction techniques for amplification of DNA made it cost-effective to sequence genes and identify polymorphic alleles.".
- Compound_heterozygosity wikiPageID "9192883".
- Compound_heterozygosity wikiPageLength "9290".
- Compound_heterozygosity wikiPageOutDegree "34".
- Compound_heterozygosity wikiPageRevisionID "667923408".
- Compound_heterozygosity wikiPageWikiLink Alcoholism.
- Compound_heterozygosity wikiPageWikiLink Allele.
- Compound_heterozygosity wikiPageWikiLink Alleles.
- Compound_heterozygosity wikiPageWikiLink Autosomal_recessive.
- Compound_heterozygosity wikiPageWikiLink Biochemistry.
- Compound_heterozygosity wikiPageWikiLink Category:Autosomal_recessive_disorders.
- Compound_heterozygosity wikiPageWikiLink Category:Genetics.
- Compound_heterozygosity wikiPageWikiLink Dominance_(genetics).
- Compound_heterozygosity wikiPageWikiLink GM2-gangliosidosis,_AB_variant.
- Compound_heterozygosity wikiPageWikiLink Genetic_disorder.
- Compound_heterozygosity wikiPageWikiLink Genetic_disorders.
- Compound_heterozygosity wikiPageWikiLink HFE_(gene).
- Compound_heterozygosity wikiPageWikiLink Hemochromatosis.
- Compound_heterozygosity wikiPageWikiLink Hemoglobin.
- Compound_heterozygosity wikiPageWikiLink Hemoglobin_C.
- Compound_heterozygosity wikiPageWikiLink Heterozygous.
- Compound_heterozygosity wikiPageWikiLink Homozygous.
- Compound_heterozygosity wikiPageWikiLink Iron.
- Compound_heterozygosity wikiPageWikiLink Iron_overload.
- Compound_heterozygosity wikiPageWikiLink Medical_genetics.
- Compound_heterozygosity wikiPageWikiLink Metabolic_pathway.
- Compound_heterozygosity wikiPageWikiLink Metabolism.
- Compound_heterozygosity wikiPageWikiLink Mutation.
- Compound_heterozygosity wikiPageWikiLink Pathophysiology.
- Compound_heterozygosity wikiPageWikiLink Penetrance.
- Compound_heterozygosity wikiPageWikiLink Phenylketonuria.
- Compound_heterozygosity wikiPageWikiLink Polymerase_chain_reaction.
- Compound_heterozygosity wikiPageWikiLink Recessive.
- Compound_heterozygosity wikiPageWikiLink Sandhoff_disease.
- Compound_heterozygosity wikiPageWikiLink Sickle-cell_disease.
- Compound_heterozygosity wikiPageWikiLink Sickle_cell.
- Compound_heterozygosity wikiPageWikiLink Sickle_cell-beta_thalassemia.
- Compound_heterozygosity wikiPageWikiLink Single_point_of_failure.
- Compound_heterozygosity wikiPageWikiLink Tay-Sachs_disease.
- Compound_heterozygosity wikiPageWikiLink Tay–Sachs_disease.
- Compound_heterozygosity wikiPageWikiLink Zygosity.
- Compound_heterozygosity wikiPageWikiLinkText "Compound heterozygosity".
- Compound_heterozygosity wikiPageWikiLinkText "Compound heterozygous".
- Compound_heterozygosity wikiPageWikiLinkText "compound heterozygosity".
- Compound_heterozygosity wikiPageWikiLinkText "compound heterozygote".
- Compound_heterozygosity wikiPageWikiLinkText "compound heterozygotes".
- Compound_heterozygosity wikiPageWikiLinkText "compound heterozygous".
- Compound_heterozygosity hasPhotoCollection Compound_heterozygosity.
- Compound_heterozygosity wikiPageUsesTemplate Template:Reflist.
- Compound_heterozygosity subject Category:Autosomal_recessive_disorders.
- Compound_heterozygosity subject Category:Genetics.
- Compound_heterozygosity hypernym Condition.
- Compound_heterozygosity type Disease.
- Compound_heterozygosity type Disorder.
- Compound_heterozygosity comment "Compound heterozygosity in medical genetics is the condition of having two heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state. That is, an organism is a compound heterozygote if it has two recessive alleles for the same gene, but with those two alleles being different from each other (for example, both alleles might be mutated but at different locations).".
- Compound_heterozygosity label "Compound heterozygosity".
- Compound_heterozygosity sameAs Komplexe_Heterozygotie.
- Compound_heterozygosity sameAs m.027_ssy.
- Compound_heterozygosity sameAs Q5156837.
- Compound_heterozygosity sameAs Q5156837.
- Compound_heterozygosity wasDerivedFrom Compound_heterozygosity?oldid=667923408.
- Compound_heterozygosity isPrimaryTopicOf Compound_heterozygosity.