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- Cofilin abstract "ADF/cofilin is a family of actin-binding proteins which disassembles actin filaments. Three highly conserved and highly (70%-82%) identical genes belonging to this family have been described in humans and mice: CFL1, coding for cofilin 1 (non-muscle, or n-cofilin) CFL2, coding for cofilin 2 (found in muscle: m-cofilin) DSTN, coding for destrin, also known as ADF or actin depolymerizing factorActin-binding proteins regulate assembly and disassembly of actin filaments. Cofilin, a member of the ADF/cofilin family is actually a protein with 70% sequence identity to ADF, making it part of the ADF/cofilin family of small ADP-binding proteins. The protein binds to actin monomers and filaments, G actin and F actin, respectively. Cofilin causes depolymerization at the minus end of filaments, thereby preventing their reassembly. The protein is known to sever actin filaments by creating more positive ends on filament fragments. Cofilin/ADF(destrin) is likely to sever F-actin without capping and prefers ADP-actin. These monomers can be recycled by profilin, activating monomers to go back into filament form again by an ADP-to-ATP exchange. ATP-actin is then available for assembly.".
- Cofilin thumbnail PDB_1cof_EBI.jpg?width=300.
- Cofilin wikiPageExternalLink 2_go-0030042.
- Cofilin wikiPageID "4135861".
- Cofilin wikiPageLength "7413".
- Cofilin wikiPageOutDegree "24".
- Cofilin wikiPageRevisionID "666642455".
- Cofilin wikiPageWikiLink Actin.
- Cofilin wikiPageWikiLink Actin-Depolymerizing_Factor.
- Cofilin wikiPageWikiLink Actin_depolymerizing_factor.
- Cofilin wikiPageWikiLink Actinin.
- Cofilin wikiPageWikiLink Adenosine_triphosphate.
- Cofilin wikiPageWikiLink 3_complex.
- Cofilin wikiPageWikiLink CFL1.
- Cofilin wikiPageWikiLink CFL2_(gene).
- Cofilin wikiPageWikiLink Category:Protein_families.
- Cofilin wikiPageWikiLink Cofilin_1.
- Cofilin wikiPageWikiLink Cofilin_2.
- Cofilin wikiPageWikiLink Cytoskeleton.
- Cofilin wikiPageWikiLink Destrin.
- Cofilin wikiPageWikiLink Gelsolin.
- Cofilin wikiPageWikiLink Monomer.
- Cofilin wikiPageWikiLink Myosin.
- Cofilin wikiPageWikiLink Profilin.
- Cofilin wikiPageWikiLink Protein.
- Cofilin wikiPageWikiLink Scruin.
- Cofilin wikiPageWikiLink Tropomyosin.
- Cofilin wikiPageWikiLink Α-actinin.
- Cofilin wikiPageWikiLink File:PDB_1cof_EBI.jpg.
- Cofilin wikiPageWikiLinkText "ADF/Cofilin".
- Cofilin wikiPageWikiLinkText "ADF/cofilin".
- Cofilin wikiPageWikiLinkText "ADF/cofilins".
- Cofilin wikiPageWikiLinkText "Cofilin".
- Cofilin wikiPageWikiLinkText "cofilin".
- Cofilin hasPhotoCollection Cofilin.
- Cofilin wikiPageUsesTemplate Template:Citation_needed.
- Cofilin wikiPageUsesTemplate Template:Cytoskeletal_Proteins.
- Cofilin wikiPageUsesTemplate Template:Reflist.
- Cofilin subject Category:Protein_families.
- Cofilin hypernym Family.
- Cofilin type Article.
- Cofilin type Biomolecule.
- Cofilin type Article.
- Cofilin type Biomolecule.
- Cofilin type Nutrient.
- Cofilin comment "ADF/cofilin is a family of actin-binding proteins which disassembles actin filaments. Three highly conserved and highly (70%-82%) identical genes belonging to this family have been described in humans and mice: CFL1, coding for cofilin 1 (non-muscle, or n-cofilin) CFL2, coding for cofilin 2 (found in muscle: m-cofilin) DSTN, coding for destrin, also known as ADF or actin depolymerizing factorActin-binding proteins regulate assembly and disassembly of actin filaments.".
- Cofilin label "Cofilin".
- Cofilin sameAs Cofilina.
- Cofilin sameAs Kofilin.
- Cofilin sameAs Cofilina.
- Cofilin sameAs Cofiline.
- Cofilin sameAs Cofilina.
- Cofilin sameAs コフィリン.
- Cofilin sameAs m.0bl0kv.
- Cofilin sameAs кофилины.
- Cofilin sameAs Q2040845.
- Cofilin sameAs Q2040845.
- Cofilin wasDerivedFrom Cofilin?oldid=666642455.
- Cofilin depiction PDB_1cof_EBI.jpg.
- Cofilin isPrimaryTopicOf Cofilin.