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- Cofactor_transferase_family abstract "In molecular biology, the Cofactor transferase family is a family of protein domains that includes biotin protein ligases, lipoate-protein ligases A, octanoyl-(acyl carrier protein):protein N-octanoyltransferases, and lipoyl-protein:protein N-lipoyltransferases. The metabolism of the cofactors Biotin and lipoic acid share this family. They also share the target modification domain (Pfam PF00364), and the sulfur insertion enzyme (Pfam PF04055).Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the biotin carboxyl carrier protein. Each organism likely has only one BPL protein. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Biotin attachment is required for biotin biosynthesis and utilization of free biotin.Lipoate-protein ligase catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue of the lipoyl domain of lipoate dependent enzymes. They are required for the utilization of free lipoic acid.Octanoyl-(acyl carrier protein):protein N-octanoyltransferases, or octanoyltransferases, are required for lipoic acid biosynthesis. They transfer octanoate from the acyl carrier protein (ACP), part of fatty acid biosynthesis, to the specific lysine residue of lipoyl domains. Two octanoyltransferase isozymes exist in this superfamily.Lipoyl-protein:protein N-lipoyltransferases, or lipoylamidotransferases, are required for lipoic acid metabolism in some organisms. They transfer lipoic acid or octanoate from lipoyl domains and transfer to other lipoyl domains. In Bacillus subtilis, the transfer is from the glycine cleavage system H protein, GcvH, to other lipoyl domains. This is because the octanoyltransferase of B. subtilis is specific for GcvH.".
- Cofactor_transferase_family symbol "BPL".
- Cofactor_transferase_family symbol "BPL_C".
- Cofactor_transferase_family symbol "Lip_prot_lig_C".
- Cofactor_transferase_family thumbnail PDB_1bia_EBI.jpg?width=300.
- Cofactor_transferase_family wikiPageID "25121692".
- Cofactor_transferase_family wikiPageLength "6371".
- Cofactor_transferase_family wikiPageOutDegree "7".
- Cofactor_transferase_family wikiPageRevisionID "607458344".
- Cofactor_transferase_family wikiPageWikiLink Biotin.
- Cofactor_transferase_family wikiPageWikiLink Biotin_protein_ligase.
- Cofactor_transferase_family wikiPageWikiLink Category:Protein_domains.
- Cofactor_transferase_family wikiPageWikiLink Lipoic_acid.
- Cofactor_transferase_family wikiPageWikiLink Lysine.
- Cofactor_transferase_family wikiPageWikiLink Protein_domain.
- Cofactor_transferase_family caption "The three-dimensional structure of BirA, the repressor of the Escherichia coli biotin biosynthetic operon.".
- Cofactor_transferase_family caption "crystal structure of putative lipoate-protein ligase from streptococcus pneumoniae tigr4 at 1.99 a resolution".
- Cofactor_transferase_family hasPhotoCollection Cofactor_transferase_family.
- Cofactor_transferase_family interpro "IPR003142".
- Cofactor_transferase_family interpro "IPR004143".
- Cofactor_transferase_family interpro "IPR019491".
- Cofactor_transferase_family name "Bacterial lipoate protein ligase C-terminus".
- Cofactor_transferase_family name "Biotin protein ligase C terminal domain".
- Cofactor_transferase_family name "Cofactor transferase domain".
- Cofactor_transferase_family pfam "PF02237".
- Cofactor_transferase_family pfam "PF03099".
- Cofactor_transferase_family pfam "PF10437".
- Cofactor_transferase_family pfamClan "CL0206".
- Cofactor_transferase_family scop "1".
- Cofactor_transferase_family symbol "BPL".
- Cofactor_transferase_family symbol "BPL_C".
- Cofactor_transferase_family symbol "Lip_prot_lig_C".
- Cofactor_transferase_family width "250".
- Cofactor_transferase_family wikiPageUsesTemplate Template:Infobox_protein_family.
- Cofactor_transferase_family wikiPageUsesTemplate Template:Orphan.
- Cofactor_transferase_family wikiPageUsesTemplate Template:Pfam.
- Cofactor_transferase_family wikiPageUsesTemplate Template:Reflist.
- Cofactor_transferase_family subject Category:Protein_domains.
- Cofactor_transferase_family hypernym Family.
- Cofactor_transferase_family type Biomolecule.
- Cofactor_transferase_family type Protein.
- Cofactor_transferase_family type Chemical.
- Cofactor_transferase_family type Domain.
- Cofactor_transferase_family type Thing.
- Cofactor_transferase_family type Q206229.
- Cofactor_transferase_family type Q8054.
- Cofactor_transferase_family comment "In molecular biology, the Cofactor transferase family is a family of protein domains that includes biotin protein ligases, lipoate-protein ligases A, octanoyl-(acyl carrier protein):protein N-octanoyltransferases, and lipoyl-protein:protein N-lipoyltransferases. The metabolism of the cofactors Biotin and lipoic acid share this family.".
- Cofactor_transferase_family label "Cofactor transferase family".
- Cofactor_transferase_family sameAs m.0gmgvsp.
- Cofactor_transferase_family sameAs Q5140875.
- Cofactor_transferase_family sameAs Q5140875.
- Cofactor_transferase_family wasDerivedFrom Cofactor_transferase_family?oldid=607458344.
- Cofactor_transferase_family depiction PDB_1bia_EBI.jpg.
- Cofactor_transferase_family isPrimaryTopicOf Cofactor_transferase_family.