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- Coagulin abstract "Coagulin is a gel-forming protein of hemolymph that hinders the spread of invaders by immobilising them.The protein contains a single 175- residue polypeptide chain; this is cleaved after Arg-18 and Arg-46 by a clotting enzyme contained in the hemocyte and activated by a bacterial endotoxin (lipopolysaccharide). Cleavage releases two chains of coagulin, A and B, linked by two disulphide bonds, together with the peptide C. Gel formation results from interlinking of coagulin molecules. Secondary structure prediction suggests the C peptide forms an alpha- helix, which is released during the proteolytic conversion of coagulogen to coagulin gel. The beta-sheet structure and 16 half-cystines found in the molecule appear to yield a compact protein stable to acid and heat.Mammalian blood coagulation is based on the proteolytically induced polymerization of fibrinogens. Initially, fibrin monomers noncovalently interact with each other. The resulting homopolymers are further stabilized when the plasma transglutaminase (TGase) intermolecularly cross-links epsilon-(gamma-glutamyl)lysine bonds. In crustaceans, hemolymph coagulation depends on the TGase-mediated cross-linking of specific plasma-clotting proteins, but without the proteolytic cascade. In horseshoe crabs, the proteolytic coagulation cascade triggered by lipopolysaccharides and beta-1,3-glucans leads to the conversion of coagulogen into coagulin, resulting in noncovalent coagulin homopolymers through head-to-tail interaction. Horseshoe crab TGase, however, does not cross-link coagulins intermolecularly. Recently, we found that coagulins are cross-linked on hemocyte cell surface proteins called proxins. This indicates that a cross-linking reaction at the final stage of hemolymph coagulation is an important innate immune system of horseshoe crabs.".
- Coagulin symbol "Coagulin".
- Coagulin wikiPageID "29049590".
- Coagulin wikiPageLength "3058".
- Coagulin wikiPageOutDegree "6".
- Coagulin wikiPageRevisionID "514382319".
- Coagulin wikiPageWikiLink Blood_coagulation.
- Coagulin wikiPageWikiLink Category:Protein_domains.
- Coagulin wikiPageWikiLink Coagulation.
- Coagulin wikiPageWikiLink Crustacean.
- Coagulin wikiPageWikiLink Crustaceans.
- Coagulin wikiPageWikiLink Fibrinogen.
- Coagulin wikiPageWikiLink Hemolymph.
- Coagulin wikiPageWikiLink Transglutaminase.
- Coagulin wikiPageWikiLinkText "coagulin".
- Coagulin hasPhotoCollection Coagulin.
- Coagulin interpro "IPR000275".
- Coagulin name "Coagulin".
- Coagulin pfam "PF02035".
- Coagulin symbol "Coagulin".
- Coagulin wikiPageUsesTemplate Template:InterPro_content.
- Coagulin wikiPageUsesTemplate Template:Orphan.
- Coagulin wikiPageUsesTemplate Template:Pfam_box.
- Coagulin wikiPageUsesTemplate Template:Protein-stub.
- Coagulin wikiPageUsesTemplate Template:Reflist.
- Coagulin subject Category:Protein_domains.
- Coagulin hypernym Protein.
- Coagulin type Article.
- Coagulin type Biomolecule.
- Coagulin type Protein.
- Coagulin type Article.
- Coagulin type Domain.
- Coagulin type Thing.
- Coagulin type Q206229.
- Coagulin type Q8054.
- Coagulin comment "Coagulin is a gel-forming protein of hemolymph that hinders the spread of invaders by immobilising them.The protein contains a single 175- residue polypeptide chain; this is cleaved after Arg-18 and Arg-46 by a clotting enzyme contained in the hemocyte and activated by a bacterial endotoxin (lipopolysaccharide). Cleavage releases two chains of coagulin, A and B, linked by two disulphide bonds, together with the peptide C. Gel formation results from interlinking of coagulin molecules.".
- Coagulin label "Coagulin".
- Coagulin sameAs m.0dgqnqf.
- Coagulin sameAs Q5137666.
- Coagulin sameAs Q5137666.
- Coagulin wasDerivedFrom Coagulin?oldid=514382319.
- Coagulin isPrimaryTopicOf Coagulin.