Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Clozapine> ?p ?o }
- Clozapine abstract "Clozapine is an atypical antipsychotic medication used in the treatment of schizophrenia, and is also sometimes used off-label for the treatment of bipolar disorder and borderline personality disorder. The first of the atypical antipsychotics to be developed, it was first introduced in Europe in 1971, but was voluntarily withdrawn by the manufacturer in 1975 after it was shown to cause agranulocytosis, a condition involving a dangerous decrease in the number of white blood cells, that led to death in some patients. In 1989 after studies demonstrated that it was effective in treating treatment-resistant schizophrenia the United States Food and Drug Administration (FDA) approved the use of clozapine solely for that use, requiring regular white blood cell and absolute neutrophil counts. The FDA also requires clozapine to carry five black box warnings for agranulocytosis, seizures, myocarditis, for "other adverse cardiovascular and respiratory effects", and for "increased mortality in elderly patients with dementia-related psychosis." In 2002 the FDA approved clozapine for reducing the risk of suicidal behavior for patients with schizophrenia.Clozapine is usually used only in patients that have not responded to other anti-psychotic treatments due to its danger of causing agranulocytosis as well as the costs of having to have blood tests continually during treatment. It is, however, one of the most effective anti-psychotic treatment choices. Patients are monitored weekly for the first six months. If there are no low counts the patient can be monitored every two weeks for an additional six months. Afterwards, the patient may qualify for every four-week monitoring. Clozapine has numerous severe side effects including agranulocytosis, and seizures, and has been associated with myocarditis and diabetes though those relationships have not been confirmed. Additionally, it also often causes less serious side effects such as hypersalivation and weight gain. It has one of the least probabilities of causing extrapyramidal side-effects.It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.".
- Clozapine atcPrefix "N05".
- Clozapine atcSuffix "AH02".
- Clozapine bioavailability "60.0".
- Clozapine casNumber "5786-21-0".
- Clozapine chEBI "3766".
- Clozapine drugbank "DB00363".
- Clozapine fdaUniiCode "J60AR2IKIC".
- Clozapine iupacName "8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine".
- Clozapine pubchem "2818".
- Clozapine thumbnail Clozapine.svg?width=300.
- Clozapine wikiPageExternalLink www.clozaril.com.
- Clozapine wikiPageExternalLink p30-c02.html.
- Clozapine wikiPageExternalLink Clozaril.pdf.
- Clozapine wikiPageID "43961".
- Clozapine wikiPageLength "41890".
- Clozapine wikiPageOutDegree "236".
- Clozapine wikiPageRevisionID "674153263".
- Clozapine wikiPageWikiLink 5-HT1A_receptor.
- Clozapine wikiPageWikiLink 5-HT1B_receptor.
- Clozapine wikiPageWikiLink 5-HT1D_receptor.
- Clozapine wikiPageWikiLink 5-HT2A_receptor.
- Clozapine wikiPageWikiLink 5-HT2B_receptor.
- Clozapine wikiPageWikiLink 5-HT2C_receptor.
- Clozapine wikiPageWikiLink 5-HT3_receptor.
- Clozapine wikiPageWikiLink 5-HT5A_receptor.
- Clozapine wikiPageWikiLink 5-HT6_receptor.
- Clozapine wikiPageWikiLink 5-HT7_receptor.
- Clozapine wikiPageWikiLink Abnormal_EEG.
- Clozapine wikiPageWikiLink Absolute_neutrophil_count.
- Clozapine wikiPageWikiLink Acetone.
- Clozapine wikiPageWikiLink Acute_megacolon.
- Clozapine wikiPageWikiLink Agranulocytosis.
- Clozapine wikiPageWikiLink Akathisia.
- Clozapine wikiPageWikiLink Akinesia.
- Clozapine wikiPageWikiLink Allosteric_regulation.
- Clozapine wikiPageWikiLink Alpha-1A_adrenergic_receptor.
- Clozapine wikiPageWikiLink Alpha-1B_adrenergic_receptor.
- Clozapine wikiPageWikiLink Alpha-2A_adrenergic_receptor.
- Clozapine wikiPageWikiLink Alpha-2B_adrenergic_receptor.
- Clozapine wikiPageWikiLink Alpha-2C_adrenergic_receptor.
- Clozapine wikiPageWikiLink Amnesia.
- Clozapine wikiPageWikiLink Animal_locomotion.
- Clozapine wikiPageWikiLink Antipsychotic.
- Clozapine wikiPageWikiLink Antipsychotics.
- Clozapine wikiPageWikiLink Anxiety.
- Clozapine wikiPageWikiLink Astrocyte.
- Clozapine wikiPageWikiLink Ataxia.
- Clozapine wikiPageWikiLink Atypical_antipsychotic.
- Clozapine wikiPageWikiLink Atypical_antipsychotics.
- Clozapine wikiPageWikiLink Benzodiazepine.
- Clozapine wikiPageWikiLink Benzodiazepines.
- Clozapine wikiPageWikiLink Beta-1_adrenergic_receptor.
- Clozapine wikiPageWikiLink Beta-2_adrenergic_receptor.
- Clozapine wikiPageWikiLink Bioavailability.
- Clozapine wikiPageWikiLink Biological_half-life.
- Clozapine wikiPageWikiLink Bipolar_disorder.
- Clozapine wikiPageWikiLink Black_box_warnings.
- Clozapine wikiPageWikiLink Blood.
- Clozapine wikiPageWikiLink Bone_marrow_suppression.
- Clozapine wikiPageWikiLink Borderline_personality_disorder.
- Clozapine wikiPageWikiLink Bowel_function.
- Clozapine wikiPageWikiLink Bowel_obstruction.
- Clozapine wikiPageWikiLink Boxed_warning.
- Clozapine wikiPageWikiLink C-reactive_protein.
- Clozapine wikiPageWikiLink CNS_depression.
- Clozapine wikiPageWikiLink CYP1A2.
- Clozapine wikiPageWikiLink CYP2D6.
- Clozapine wikiPageWikiLink CYP2E1.
- Clozapine wikiPageWikiLink CYP3A4.
- Clozapine wikiPageWikiLink Carbamazepine.
- Clozapine wikiPageWikiLink Carbohydrate.
- Clozapine wikiPageWikiLink Carbohydrates.
- Clozapine wikiPageWikiLink Cardiac_failure.
- Clozapine wikiPageWikiLink Cardiovascular_disease.
- Clozapine wikiPageWikiLink Category:Atypical_antipsychotics.
- Clozapine wikiPageWikiLink Category:Chloroarenes.
- Clozapine wikiPageWikiLink Category:Dibenzodiazepines.
- Clozapine wikiPageWikiLink Category:Dopamine_agonists.
- Clozapine wikiPageWikiLink Category:Dopamine_antagonists.
- Clozapine wikiPageWikiLink Category:Mood_stabilizers.
- Clozapine wikiPageWikiLink Category:Piperazines.
- Clozapine wikiPageWikiLink Category:Serotonin_antagonists.
- Clozapine wikiPageWikiLink Central_nervous_system_depression.
- Clozapine wikiPageWikiLink Chemical_polarity.
- Clozapine wikiPageWikiLink Chloroform.
- Clozapine wikiPageWikiLink Cholinergic.
- Clozapine wikiPageWikiLink Ciprofloxacin.
- Clozapine wikiPageWikiLink Complete_blood_count.
- Clozapine wikiPageWikiLink Confusion.
- Clozapine wikiPageWikiLink Constipation.
- Clozapine wikiPageWikiLink Cytochrome_P450.
- Clozapine wikiPageWikiLink DHA-clozapine.
- Clozapine wikiPageWikiLink Delirium.
- Clozapine wikiPageWikiLink Delta_opioid_receptor.
- Clozapine wikiPageWikiLink Delusion.
- Clozapine wikiPageWikiLink Delusions.
- Clozapine wikiPageWikiLink Dementia.
- Clozapine wikiPageWikiLink Demethylation.
- Clozapine wikiPageWikiLink Depression_(mood).