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- Citrate_synthase_family abstract "In molecular biology, the citrate synthase family of proteins includes the enzymes citrate synthase EC 2.3.3.1, and the related enzymes 2-methylcitrate synthase EC 2.3.3.5 and ATP citrate synthase EC 2.3.3.8.Citrate synthase is a member of a small family of enzymes that can directly form a carbon-carbon bond without the presence of metal ion cofactors. It catalyses the first reaction in the Krebs' cycle, namely the conversion of oxaloacetate and acetyl-coenzyme A into citrate and coenzyme A. This reaction is important for energy generation and for carbon assimilation. The reaction proceeds via a non-covalently bound citryl-coenzyme A intermediate in a 2-step process (aldol-Claisen condensation followed by the hydrolysis of citryl-CoA). Citrate synthase enzymes are found in two distinct structural types: type I enzymes (found in eukaryotes, Gram-positive bacteria and archaea) form homodimers and have shorter sequences than type II enzymes, which are found in Gram-negative bacteria and are hexameric in structure. In both types, the monomer is composed of two domains: a large alpha-helical domain consisting of two structural repeats, where the second repeat is interrupted by a small alpha-helical domain. The cleft between these domains forms the active site, where both citrate and acetyl-coenzyme A bind. The enzyme undergoes a conformational change upon binding of the oxaloacetate ligand, whereby the active site cleft closes over in order to form the acetyl-CoA binding site. The energy required for domain closure comes from the interaction of the enzyme with the substrate. Type II enzymes possess an extra N-terminal beta-sheet domain, and some type II enzymes are allosterically inhibited by NADH.2-methylcitrate synthase catalyses the conversion of oxaloacetate and propanoyl-CoA into (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate and coenzyme A. This enzyme is induced during bacterial growth on propionate, while type II hexameric citrate synthase is constitutive.ATP citrate synthase (also known as ATP citrate lyase) catalyses the MgATP-dependent, CoA-dependent cleavage of citrate into oxaloacetate and acetyl-CoA, a key step in the reductive tricarboxylic acid pathway of CO2 assimilation used by a variety of autotrophic bacteria and archaea to fix carbon dioxide. ATP citrate synthase is composed of two distinct subunits. In eukaryotes, ATP citrate synthase is a homotetramer of a single large polypeptide, and is used to produce cytosolic acetyl-CoA from mitochondrial produced citrate.".
- Citrate_synthase_family symbol "Citrate_synt".
- Citrate_synthase_family thumbnail PDB_1a59_EBI.jpg?width=300.
- Citrate_synthase_family wikiPageID "32270776".
- Citrate_synthase_family wikiPageLength "5226".
- Citrate_synthase_family wikiPageOutDegree "47".
- Citrate_synthase_family wikiPageRevisionID "607202558".
- Citrate_synthase_family wikiPageWikiLink 2-methylcitrate_synthase.
- Citrate_synthase_family wikiPageWikiLink ATP_citrate_synthase.
- Citrate_synthase_family wikiPageWikiLink Acetyl-CoA.
- Citrate_synthase_family wikiPageWikiLink Acetyl-coenzyme_A.
- Citrate_synthase_family wikiPageWikiLink Active_site.
- Citrate_synthase_family wikiPageWikiLink Allosteric_regulation.
- Citrate_synthase_family wikiPageWikiLink Allosterically.
- Citrate_synthase_family wikiPageWikiLink Alpha_helix.
- Citrate_synthase_family wikiPageWikiLink Archaea.
- Citrate_synthase_family wikiPageWikiLink Autotroph.
- Citrate_synthase_family wikiPageWikiLink Autotrophic.
- Citrate_synthase_family wikiPageWikiLink Bacteria.
- Citrate_synthase_family wikiPageWikiLink Bacterium.
- Citrate_synthase_family wikiPageWikiLink Beta-sheet.
- Citrate_synthase_family wikiPageWikiLink Beta_sheet.
- Citrate_synthase_family wikiPageWikiLink Binding_site.
- Citrate_synthase_family wikiPageWikiLink Biocatalysis.
- Citrate_synthase_family wikiPageWikiLink Carbon.
- Citrate_synthase_family wikiPageWikiLink Carbon_dioxide.
- Citrate_synthase_family wikiPageWikiLink Catalyse.
- Citrate_synthase_family wikiPageWikiLink Catalysis.
- Citrate_synthase_family wikiPageWikiLink Category:Protein_domains.
- Citrate_synthase_family wikiPageWikiLink Citrate.
- Citrate_synthase_family wikiPageWikiLink Citrate_synthase.
- Citrate_synthase_family wikiPageWikiLink Citric_acid_cycle.
- Citrate_synthase_family wikiPageWikiLink Coenzyme_A.
- Citrate_synthase_family wikiPageWikiLink Cofactor_(biochemistry).
- Citrate_synthase_family wikiPageWikiLink Conformational_change.
- Citrate_synthase_family wikiPageWikiLink Cytoplasm.
- Citrate_synthase_family wikiPageWikiLink Energy.
- Citrate_synthase_family wikiPageWikiLink Enzyme.
- Citrate_synthase_family wikiPageWikiLink Enzyme_substrate.
- Citrate_synthase_family wikiPageWikiLink Enzymes.
- Citrate_synthase_family wikiPageWikiLink Eukaryote.
- Citrate_synthase_family wikiPageWikiLink Eukaryotes.
- Citrate_synthase_family wikiPageWikiLink Gram-negative_bacteria.
- Citrate_synthase_family wikiPageWikiLink Gram-positive_bacteria.
- Citrate_synthase_family wikiPageWikiLink Homodimer.
- Citrate_synthase_family wikiPageWikiLink Hydrolysis.
- Citrate_synthase_family wikiPageWikiLink Krebs.
- Citrate_synthase_family wikiPageWikiLink Metal.
- Citrate_synthase_family wikiPageWikiLink Metal_ion.
- Citrate_synthase_family wikiPageWikiLink Mitochondrion.
- Citrate_synthase_family wikiPageWikiLink Monomer.
- Citrate_synthase_family wikiPageWikiLink N-terminal.
- Citrate_synthase_family wikiPageWikiLink N-terminus.
- Citrate_synthase_family wikiPageWikiLink NADH.
- Citrate_synthase_family wikiPageWikiLink Nicotinamide_adenine_dinucleotide.
- Citrate_synthase_family wikiPageWikiLink Oxaloacetate.
- Citrate_synthase_family wikiPageWikiLink Oxaloacetic_acid.
- Citrate_synthase_family wikiPageWikiLink Propionate.
- Citrate_synthase_family wikiPageWikiLink Protein.
- Citrate_synthase_family wikiPageWikiLink Protein_dimer.
- Citrate_synthase_family wikiPageWikiLink Protein_subunit.
- Citrate_synthase_family wikiPageWikiLink Proteins.
- Citrate_synthase_family wikiPageWikiLink Reaction_intermediate.
- Citrate_synthase_family wikiPageWikiLink Sequence_(biology).
- Citrate_synthase_family wikiPageWikiLink Substrate_(chemistry).
- Citrate_synthase_family wikiPageWikiLink TCA_cycle.
- Citrate_synthase_family caption "cold-active citrate synthase".
- Citrate_synthase_family cdd "cd06101".
- Citrate_synthase_family hasPhotoCollection Citrate_synthase_family.
- Citrate_synthase_family interpro "IPR002020".
- Citrate_synthase_family name "Citrate_synt".
- Citrate_synthase_family pfam "PF00285".
- Citrate_synthase_family prosite "PDOC00422".
- Citrate_synthase_family scop "1".
- Citrate_synthase_family symbol "Citrate_synt".
- Citrate_synthase_family wikiPageUsesTemplate Template:EC_number.
- Citrate_synthase_family wikiPageUsesTemplate Template:Infobox_protein_family.
- Citrate_synthase_family wikiPageUsesTemplate Template:InterPro_content.
- Citrate_synthase_family wikiPageUsesTemplate Template:Reflist.
- Citrate_synthase_family subject Category:Protein_domains.
- Citrate_synthase_family hypernym Member.
- Citrate_synthase_family type Biomolecule.
- Citrate_synthase_family type Person.
- Citrate_synthase_family type Protein.
- Citrate_synthase_family type Chemical.
- Citrate_synthase_family type Domain.
- Citrate_synthase_family type Thing.
- Citrate_synthase_family type Q206229.
- Citrate_synthase_family type Q8054.
- Citrate_synthase_family comment "In molecular biology, the citrate synthase family of proteins includes the enzymes citrate synthase EC 2.3.3.1, and the related enzymes 2-methylcitrate synthase EC 2.3.3.5 and ATP citrate synthase EC 2.3.3.8.Citrate synthase is a member of a small family of enzymes that can directly form a carbon-carbon bond without the presence of metal ion cofactors. It catalyses the first reaction in the Krebs' cycle, namely the conversion of oxaloacetate and acetyl-coenzyme A into citrate and coenzyme A.".
- Citrate_synthase_family label "Citrate synthase family".
- Citrate_synthase_family sameAs m.0gy1kpx.
- Citrate_synthase_family sameAs Q5122813.
- Citrate_synthase_family sameAs Q5122813.
- Citrate_synthase_family wasDerivedFrom Citrate_synthase_family?oldid=607202558.
- Citrate_synthase_family depiction PDB_1a59_EBI.jpg.
- Citrate_synthase_family isPrimaryTopicOf Citrate_synthase_family.