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- Cingulin-like_1 abstract "Cingulin-like 1, also known as paracingulin or junction-associated-coiled-coil protein (JACOP), is a protein which is encoded by the CGNL1 gene.The paracingulin polypeptide comprises a globular N-terminal "head" domain and an α-helical C-terminal domain which is presumed to form a coiled-coil dimer. Paracingulin is a paralog of cingulin that arose probably from gene duplication. The CGNL1 gene is conserved among different vertebrate species and has not been so far identified in invertebrates. The homology search highlights that paracingulin and cingulin have 39% identity in the rod tail sequences. They possess also two highly homologous regions in their N-terminus “head” domain including the ZIM region (ZO-1 interaction motif).The etymology of the name cingulin comes from the Latin "cingere" which means « to form a belt around ». Both, cingulin and paracingulin are localized in the cytoplasmic face of tight junctions (TJ). The prefix « para » refers to “paralog”. However, immunoelectron microscopy indicates that paracingulin is not only localized in the TJ but also in the adherens junctions (AJ) depending on tissue type. TJ and AJ together form the apical junctional complex (AJC) of vertebrate epithelial cells. The proteins present in this complex play a role in many cellular processes i.e., in the adhesion and barrier function of epithelia, the organization and dynamics of the cytoskeleton, as well as the regulation of Rho-GTPase family.".
- Cingulin-like_1 entrezgene "84952".
- Cingulin-like_1 wikiPageExternalLink MB_cgi?mode=&index=202864&field=all&HM=&II=&PA=&form=&input=.
- Cingulin-like_1 wikiPageID "19818063".
- Cingulin-like_1 wikiPageLength "16650".
- Cingulin-like_1 wikiPageOutDegree "29".
- Cingulin-like_1 wikiPageRevisionID "676109404".
- Cingulin-like_1 wikiPageWikiLink 1p36_deletion_syndrome.
- Cingulin-like_1 wikiPageWikiLink Actin.
- Cingulin-like_1 wikiPageWikiLink Adherens_junction.
- Cingulin-like_1 wikiPageWikiLink Adherens_junctions.
- Cingulin-like_1 wikiPageWikiLink Aromatase_excess_syndrome.
- Cingulin-like_1 wikiPageWikiLink CD2AP.
- Cingulin-like_1 wikiPageWikiLink CDC42.
- Cingulin-like_1 wikiPageWikiLink CapZ.
- Cingulin-like_1 wikiPageWikiLink Cdc42.
- Cingulin-like_1 wikiPageWikiLink Cell_culture.
- Cingulin-like_1 wikiPageWikiLink Cell_junction.
- Cingulin-like_1 wikiPageWikiLink Cingulin.
- Cingulin-like_1 wikiPageWikiLink Cytochrome_P450.
- Cingulin-like_1 wikiPageWikiLink Cytoskeleton.
- Cingulin-like_1 wikiPageWikiLink Epithelial.
- Cingulin-like_1 wikiPageWikiLink Epithelium.
- Cingulin-like_1 wikiPageWikiLink Fibroblast.
- Cingulin-like_1 wikiPageWikiLink Guanine_nucleotide_exchange_factor.
- Cingulin-like_1 wikiPageWikiLink Heterozygous.
- Cingulin-like_1 wikiPageWikiLink Medical_Subject_Headings.
- Cingulin-like_1 wikiPageWikiLink Protein.
- Cingulin-like_1 wikiPageWikiLink Rho_family_of_GTPases.
- Cingulin-like_1 wikiPageWikiLink SH3BP1.
- Cingulin-like_1 wikiPageWikiLink Schizophrenia.
- Cingulin-like_1 wikiPageWikiLink ShRNA.
- Cingulin-like_1 wikiPageWikiLink Small_hairpin_RNA.
- Cingulin-like_1 wikiPageWikiLink T-cell_lymphoma_invasion_and_metastasis-inducing_protein_1.
- Cingulin-like_1 wikiPageWikiLink Tight_junction.
- Cingulin-like_1 wikiPageWikiLink Tight_junction_protein_1.
- Cingulin-like_1 wikiPageWikiLink Tight_junctions.
- Cingulin-like_1 wikiPageWikiLink Two-hybrid_screening.
- Cingulin-like_1 wikiPageWikiLink Yeast_two-hybrid.
- Cingulin-like_1 wikiPageWikiLink ZO-1.
- Cingulin-like_1 wikiPageWikiLink Zygosity.
- Cingulin-like_1 wikiPageWikiLinkText "CGNL1".
- Cingulin-like_1 wikiPageWikiLinkText "Cingulin-like 1".
- Cingulin-like_1 wikiPageWikiLinkText "paracingulin".
- Cingulin-like_1 hasPhotoCollection Cingulin-like_1.
- Cingulin-like_1 wikiPageUsesTemplate Template:PBB.
- Cingulin-like_1 wikiPageUsesTemplate Template:Reflist.
- Cingulin-like_1 hypernym Protein.
- Cingulin-like_1 type Biomolecule.
- Cingulin-like_1 type Protein.
- Cingulin-like_1 type Thing.
- Cingulin-like_1 type Q206229.
- Cingulin-like_1 type Q8054.
- Cingulin-like_1 comment "Cingulin-like 1, also known as paracingulin or junction-associated-coiled-coil protein (JACOP), is a protein which is encoded by the CGNL1 gene.The paracingulin polypeptide comprises a globular N-terminal "head" domain and an α-helical C-terminal domain which is presumed to form a coiled-coil dimer. Paracingulin is a paralog of cingulin that arose probably from gene duplication. The CGNL1 gene is conserved among different vertebrate species and has not been so far identified in invertebrates.".
- Cingulin-like_1 label "Cingulin-like 1".
- Cingulin-like_1 sameAs m.04q9gbg.
- Cingulin-like_1 sameAs Q5120919.
- Cingulin-like_1 sameAs Q5120919.
- Cingulin-like_1 wasDerivedFrom Cingulin-like_1?oldid=676109404.
- Cingulin-like_1 isPrimaryTopicOf Cingulin-like_1.