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- Cilengitide abstract "Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor biology. Hence, it is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.The European Medicines Agency has granted cilengitide orphan drug status.Cilengitide seems to function by inhibiting the FAK/src/AKT pathway and inducing apoptosis in endothelial cells. Preclinical studies in mice of cilengitide were able to demonstrate efficacious tumor regression.Phase II studies were able to demonstrate that cilengitide as a potential monotherapy in patients with recurrent glioblastoma with high intratumor drug levels when 2000 mg of cilengitide is given twice weekly. In a rat xenograft model, cilengitide was able to potentiate the cytotoxic effects of radiation when cilengitide was administered prior to radiation therapy. When combined with radiation, inhibition of integrin expression by cilengitide synergistically improves the cytotoxic effects of ionizing radiation for glioblastoma. Cilengitide is well tolerated, in combination with radiation and temozolomide, at a dose of 2000 mg in patients with newly diagnosed glioblastoma, regardless of MGMT promoter status. In a phase I/IIa study, the addition of cilengitide to the standard of care for newly diagnosed glioblastoma (surgical resection followed by temozolomide and radiation therapy) improves progression-free survival and overall survival in patients with MGMT promoter methylation.However, in a subsequent study, cilengitide does not seem to alter the pattern of glioblastoma progression, and in an EORTC phase III randomized, controlled, multicenter clinical trial, consisting of over 500 patients in 23 countries, the addition of cilengitide to the standard of care did not improve overall survival in patients with newly diagnosed glioblastoma and methylated MGMT promoter status A phase II study, the CORE trial, is currently being conducted in patients with newly diagnosed glioblastoma and unmethylated MGMT promoter status.".
- Cilengitide iupacName "2-[(2S,5R,8S,11S)-5-benzyl-11-{3-[(diaminomethylidene)amino]propyl}-7-methyl-3,6,9,12,15-pentaoxo-8-(propan-2-yl)-1,4,7,10,13-pentaazacyclopentadecan-2-yl]acetic acid".
- Cilengitide thumbnail Cilengitide.svg?width=300.
- Cilengitide wikiPageID "10244438".
- Cilengitide wikiPageLength "8576".
- Cilengitide wikiPageOutDegree "13".
- Cilengitide wikiPageRevisionID "668559386".
- Cilengitide wikiPageWikiLink Angiogenesis.
- Cilengitide wikiPageWikiLink Category:Experimental_cancer_drugs.
- Cilengitide wikiPageWikiLink Category:Macrocycles.
- Cilengitide wikiPageWikiLink Category:Orphan_drugs.
- Cilengitide wikiPageWikiLink Category:Peptides.
- Cilengitide wikiPageWikiLink Darmstadt.
- Cilengitide wikiPageWikiLink European_Medicines_Agency.
- Cilengitide wikiPageWikiLink Glioblastoma.
- Cilengitide wikiPageWikiLink Glioblastoma_multiforme.
- Cilengitide wikiPageWikiLink Integrin.
- Cilengitide wikiPageWikiLink Merck_KGaA.
- Cilengitide wikiPageWikiLink Orphan_drug.
- Cilengitide wikiPageWikiLink Peptide.
- Cilengitide wikiPageWikiLink Technical_University_Munich.
- Cilengitide wikiPageWikiLink Technische_Universität_München.
- Cilengitide wikiPageWikiLinkText "Cilengitide".
- Cilengitide wikiPageWikiLinkText "cilengitide".
- Cilengitide hasPhotoCollection Cilengitide.
- Cilengitide imagefile "Cilengitide.svg".
- Cilengitide imagesize "300".
- Cilengitide iupacname "2".
- Cilengitide verifiedfields "changed".
- Cilengitide verifiedrevid "460036937".
- Cilengitide watchedfields "changed".
- Cilengitide wikiPageUsesTemplate Template:Chembox.
- Cilengitide wikiPageUsesTemplate Template:Reflist.
- Cilengitide subject Category:Experimental_cancer_drugs.
- Cilengitide subject Category:Macrocycles.
- Cilengitide subject Category:Orphan_drugs.
- Cilengitide subject Category:Peptides.
- Cilengitide hypernym Molecule.
- Cilengitide type Biomolecule.
- Cilengitide type ChemicalCompound.
- Cilengitide type ChemicalSubstance.
- Cilengitide type Drug.
- Cilengitide type Biomolecule.
- Cilengitide type Drug.
- Cilengitide type Macrocycle.
- Cilengitide type Peptide.
- Cilengitide type ChemicalObject.
- Cilengitide type Thing.
- Cilengitide type Q11173.
- Cilengitide comment "Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor biology.".
- Cilengitide label "Cilengitide".
- Cilengitide sameAs Cilengitid.
- Cilengitide sameAs m.02q6bst.
- Cilengitide sameAs Cilengitid.
- Cilengitide sameAs Cilengitid.
- Cilengitide sameAs Q1091921.
- Cilengitide sameAs Q1091921.
- Cilengitide wasDerivedFrom Cilengitide?oldid=668559386.
- Cilengitide depiction Cilengitide.svg.
- Cilengitide isPrimaryTopicOf Cilengitide.