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- Chordin abstract "Chordin is a bone morphogenetic protein antagonist composed of four small cysteine-rich domains, whose function is not known. Chordin was originally identified in Xenopus laevis in the laboratory of Edward M. De Robertis as a key developmental protein that dorsalizes early vertebrate embryonic tissues. The polypeptide is 941 amino acids long and 120 kDa large and it dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as bone morphogenetic proteins. It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.In mice, Chordin is expressed in the node but not in the anterior visceral endoderm. It has been found to be required for forebrain development. In developing mice that are deficient in both chordin and noggin, the head is nearly absent. This is significant because when only noggin is deficient there are mild defects but the head still forms.In humans, the chordin peptide is encoded by the CHRD gene.Chordin is also involved in avian gastrulation. It is expressed in the anterior cells of Koller's sickle, which form the anterior cells of the primitive streak, a key structure through which gastrulation occurs.".
- Chordin arm "q".
- Chordin band "27".
- Chordin chromosome "3".
- Chordin entrezgene "8646".
- Chordin hgncid "1949".
- Chordin omim "603475".
- Chordin refseq "NM_003741".
- Chordin symbol "CHRD".
- Chordin uniprot "Q9H2X0".
- Chordin wikiPageID "5737035".
- Chordin wikiPageLength "5055".
- Chordin wikiPageOutDegree "24".
- Chordin wikiPageRevisionID "660927908".
- Chordin wikiPageWikiLink African_clawed_frog.
- Chordin wikiPageWikiLink Alternative_splicing.
- Chordin wikiPageWikiLink Anatomical_terms_of_location.
- Chordin wikiPageWikiLink Antagonist.
- Chordin wikiPageWikiLink Bone_morphogenetic_protein.
- Chordin wikiPageWikiLink Category:CHRD_domain.
- Chordin wikiPageWikiLink Category:Developmental_biology.
- Chordin wikiPageWikiLink Category:Proteins.
- Chordin wikiPageWikiLink Category:VWFC_domain.
- Chordin wikiPageWikiLink Dorsum_(biology).
- Chordin wikiPageWikiLink Edward_M._De_Robertis.
- Chordin wikiPageWikiLink Embryo.
- Chordin wikiPageWikiLink Endoderm.
- Chordin wikiPageWikiLink Forebrain.
- Chordin wikiPageWikiLink Gene.
- Chordin wikiPageWikiLink Isoform.
- Chordin wikiPageWikiLink Kollers_sickle.
- Chordin wikiPageWikiLink Noggin_(protein).
- Chordin wikiPageWikiLink Organogenesis.
- Chordin wikiPageWikiLink Peptide.
- Chordin wikiPageWikiLink Polypeptide.
- Chordin wikiPageWikiLink Primitive_streak.
- Chordin wikiPageWikiLink Protein.
- Chordin wikiPageWikiLink Protein_isoform.
- Chordin wikiPageWikiLink TGFβ.
- Chordin wikiPageWikiLink Transforming_growth_factor_beta.
- Chordin wikiPageWikiLink Vertebrate.
- Chordin wikiPageWikiLink Xenopus_laevis.
- Chordin wikiPageWikiLinkText "''CHRD''".
- Chordin wikiPageWikiLinkText "Chordin".
- Chordin wikiPageWikiLinkText "chordin".
- Chordin arm "q".
- Chordin band "27".
- Chordin chromosome "3".
- Chordin entrezgene "8646".
- Chordin hasPhotoCollection Chordin.
- Chordin hgncid "1949".
- Chordin interpro "IPR010895".
- Chordin name "CHRD domain".
- Chordin name "chordin".
- Chordin omim "603475".
- Chordin pfam "PF07452".
- Chordin prosite "PS50933".
- Chordin refseq "NM_003741".
- Chordin smart "SM00754".
- Chordin symbol "CHRD".
- Chordin uniprot "Q9H2X0".
- Chordin wikiPageUsesTemplate Template:Molecular-cell-biology-stub.
- Chordin wikiPageUsesTemplate Template:Pfam_box.
- Chordin wikiPageUsesTemplate Template:Protein.
- Chordin wikiPageUsesTemplate Template:Reflist.
- Chordin wikiPageUsesTemplate Template:TGF_beta_signaling.
- Chordin subject Category:CHRD_domain.
- Chordin subject Category:Developmental_biology.
- Chordin subject Category:Proteins.
- Chordin subject Category:VWFC_domain.
- Chordin hypernym Antagonist.
- Chordin type Biomolecule.
- Chordin type Drug.
- Chordin type Protein.
- Chordin type Biomolecule.
- Chordin type Domain.
- Chordin type Nutrient.
- Chordin type Thing.
- Chordin type Q206229.
- Chordin type Q8054.
- Chordin comment "Chordin is a bone morphogenetic protein antagonist composed of four small cysteine-rich domains, whose function is not known. Chordin was originally identified in Xenopus laevis in the laboratory of Edward M. De Robertis as a key developmental protein that dorsalizes early vertebrate embryonic tissues. The polypeptide is 941 amino acids long and 120 kDa large and it dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as bone morphogenetic proteins.".
- Chordin label "Chordin".
- Chordin sameAs Chordine.
- Chordin sameAs Chordyna.
- Chordin sameAs m.0f20vx.
- Chordin sameAs Q2964503.
- Chordin sameAs Q2964503.
- Chordin wasDerivedFrom Chordin?oldid=660927908.
- Chordin isPrimaryTopicOf Chordin.