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- Chemically_linked_Fab abstract "Two chemically linked fragments antigen-binding form an artificial antibody that binds to two different antigens, making it a type of bispecific antibody. They are fragments antigen-binding (Fab or Fab') of two different monoclonal antibodies and are linked by chemical means like a thioether. Typically, one of the Fabs binds to a tumour antigen (such as CD30) and the other to a protein on the surface of an immune cell, for example an Fc receptor on a macrophage. In this way, tumour cells are attached to immune cells, which destroy them.In the late 1990s and early 2000s, clinical trials with chemically linked Fabs were conducted for the treatment of various types of cancer. Early results were promising, but the concept was dropped because of high production costs.Bi-specific T-cell engagers employ a similar mechanism of action while being cheaper.".
- Chemically_linked_Fab thumbnail Chemically_linked_Fab.svgwidth=300.
- Chemically_linked_Fab wikiPageID "28026714".
- Chemically_linked_Fab wikiPageLength "4136".
- Chemically_linked_Fab wikiPageOutDegree "17".
- Chemically_linked_Fab wikiPageRevisionID "678218198".
- Chemically_linked_Fab wikiPageWikiLink Antibody.
- Chemically_linked_Fab wikiPageWikiLink Antigen.
- Chemically_linked_Fab wikiPageWikiLink Antigens.
- Chemically_linked_Fab wikiPageWikiLink Bi-specific_T-cell_engager.
- Chemically_linked_Fab wikiPageWikiLink Bispecific_antibody.
- Chemically_linked_Fab wikiPageWikiLink Bispecific_monoclonal_antibody.
- Chemically_linked_Fab wikiPageWikiLink CD30.
- Chemically_linked_Fab wikiPageWikiLink Cancer.
- Chemically_linked_Fab wikiPageWikiLink Category:Antineoplastic_drugs.
- Chemically_linked_Fab wikiPageWikiLink Category:Monoclonal_antibodies.
- Chemically_linked_Fab wikiPageWikiLink Clinical_trial.
- Chemically_linked_Fab wikiPageWikiLink Fc_receptor.
- Chemically_linked_Fab wikiPageWikiLink Fragment_antigen-binding.
- Chemically_linked_Fab wikiPageWikiLink Immune_cell.
- Chemically_linked_Fab wikiPageWikiLink Macrophage.
- Chemically_linked_Fab wikiPageWikiLink Monoclonal_antibodies.
- Chemically_linked_Fab wikiPageWikiLink Monoclonal_antibody.
- Chemically_linked_Fab wikiPageWikiLink Thioether.
- Chemically_linked_Fab wikiPageWikiLink Tumor_antigen.
- Chemically_linked_Fab wikiPageWikiLink Tumour_antigen.
- Chemically_linked_Fab wikiPageWikiLink White_blood_cell.
- Chemically_linked_Fab wikiPageWikiLink File:Chemically_linked_Fab.svg.
- Chemically_linked_Fab wikiPageWikiLinkText "Chemically linked Fab".
- Chemically_linked_Fab wikiPageWikiLinkText "chemically linked Fab".
- Chemically_linked_Fab hasPhotoCollection Chemically_linked_Fab.
- Chemically_linked_Fab wikiPageUsesTemplate Template:Antineoplastic-drug-stub.
- Chemically_linked_Fab wikiPageUsesTemplate Template:Engineered_antibodies.
- Chemically_linked_Fab wikiPageUsesTemplate Template:Monoclonal-antibody-stub.
- Chemically_linked_Fab wikiPageUsesTemplate Template:Reflist.
- Chemically_linked_Fab subject Category:Antineoplastic_drugs.
- Chemically_linked_Fab subject Category:Monoclonal_antibodies.
- Chemically_linked_Fab type Article.
- Chemically_linked_Fab type Drug.
- Chemically_linked_Fab type Antibody.
- Chemically_linked_Fab type Article.
- Chemically_linked_Fab type Drug.
- Chemically_linked_Fab comment "Two chemically linked fragments antigen-binding form an artificial antibody that binds to two different antigens, making it a type of bispecific antibody. They are fragments antigen-binding (Fab or Fab') of two different monoclonal antibodies and are linked by chemical means like a thioether. Typically, one of the Fabs binds to a tumour antigen (such as CD30) and the other to a protein on the surface of an immune cell, for example an Fc receptor on a macrophage.".
- Chemically_linked_Fab label "Chemically linked Fab".
- Chemically_linked_Fab sameAs Fab_chimicamente_legati.
- Chemically_linked_Fab sameAs m.0cmb613.
- Chemically_linked_Fab sameAs Q3737468.
- Chemically_linked_Fab sameAs Q3737468.
- Chemically_linked_Fab wasDerivedFrom Chemically_linked_Fab?oldid=678218198.
- Chemically_linked_Fab depiction Chemically_linked_Fab.svg.
- Chemically_linked_Fab isPrimaryTopicOf Chemically_linked_Fab.