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- Cerulenin abstract "Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1, another enzyme normally inhibited by malonyl-CoA. Inhibition involves covalent thioacylation that permanently inactivates the enzymes. These two behaviors may increase the availability of energy in the form of ATP, perhaps sensed by AMPK, in the hypothalamus.In sterol synthesis, cerulenin inhibits HMG-CoA synthetase activity. It was also reported that cerulenin specifically inhibited fatty acid biosynthesis in Saccharomyces cerevisiae without having an effect on sterol formation. But in general conclusion, cerulenin has inhibitory effects on sterol synthesis.Cerulenin causes a dose-dependent decrease in HER2/neu protein levels in breast cancer cells, from 14% at 1.25 to 78% at 10 milligrams per liter, and targeting of fatty acid synthase by related drugs has been suggested as a possible treatment. Antiproliferative and pro-apoptotic effects have been shown in colon cells as well. At an intraperitoneal dose of 30 milligrams per kilogram, it has been shown to inhibit feeding and induce dramatic weight loss in mice by a mechanism similar to, but independent or downstream of, leptin signaling. It is found naturally in the industrial strain Cephalosporium caerulens (Sarocladium oryzae, the sheath rot pathogen of rice).".
- Cerulenin iupacName "(2R,​3S)-​3-​[(4E,​7E)-​nona-​4,​7-​dienoyl]​oxirane-​2-​carboxamide".
- Cerulenin thumbnail Cerulenin.svg?width=300.
- Cerulenin wikiPageExternalLink cerulenin.htm.
- Cerulenin wikiPageID "4207339".
- Cerulenin wikiPageLength "5656".
- Cerulenin wikiPageOutDegree "22".
- Cerulenin wikiPageRevisionID "670377762".
- Cerulenin wikiPageWikiLink AMP-activated_protein_kinase.
- Cerulenin wikiPageWikiLink Adenosine_triphosphate.
- Cerulenin wikiPageWikiLink Antibiotic.
- Cerulenin wikiPageWikiLink Antibiotics.
- Cerulenin wikiPageWikiLink Antifungal.
- Cerulenin wikiPageWikiLink Antifungal_drug.
- Cerulenin wikiPageWikiLink Apoptosis.
- Cerulenin wikiPageWikiLink Apoptotic.
- Cerulenin wikiPageWikiLink CPT1.
- Cerulenin wikiPageWikiLink Carnitine_palmitoyltransferase_I.
- Cerulenin wikiPageWikiLink Category:Alkenes.
- Cerulenin wikiPageWikiLink Category:Amides.
- Cerulenin wikiPageWikiLink Category:Antifungals.
- Cerulenin wikiPageWikiLink Category:Epoxides.
- Cerulenin wikiPageWikiLink Category:Ketones.
- Cerulenin wikiPageWikiLink Fatty_acid.
- Cerulenin wikiPageWikiLink Fatty_acid_synthase.
- Cerulenin wikiPageWikiLink Fermentek.
- Cerulenin wikiPageWikiLink neu.
- Cerulenin wikiPageWikiLink Hypothalamus.
- Cerulenin wikiPageWikiLink Intraperitoneal.
- Cerulenin wikiPageWikiLink Leptin.
- Cerulenin wikiPageWikiLink Malonyl-CoA.
- Cerulenin wikiPageWikiLink Peritoneum.
- Cerulenin wikiPageWikiLink Saccharomyces_cerevisiae.
- Cerulenin wikiPageWikiLink Sarocladium_oryzae.
- Cerulenin wikiPageWikiLinkText "Cerulenin".
- Cerulenin wikiPageWikiLinkText "cerulenin".
- Cerulenin hasPhotoCollection Cerulenin.
- Cerulenin imagefile "Cerulenin.svg".
- Cerulenin imagesize "280".
- Cerulenin iupacname "-​3-​[-​nona-​4,​7-​dienoyl]​oxirane-​2-​carboxamide".
- Cerulenin verifiedfields "changed".
- Cerulenin verifiedrevid "401951338".
- Cerulenin watchedfields "changed".
- Cerulenin wikiPageUsesTemplate Template:Chembox.
- Cerulenin wikiPageUsesTemplate Template:Reflist.
- Cerulenin subject Category:Alkenes.
- Cerulenin subject Category:Amides.
- Cerulenin subject Category:Antifungals.
- Cerulenin subject Category:Epoxides.
- Cerulenin subject Category:Ketones.
- Cerulenin hypernym Antifungal.
- Cerulenin type ChemicalCompound.
- Cerulenin type ChemicalSubstance.
- Cerulenin type Drug.
- Cerulenin type Group.
- Cerulenin type Alkene.
- Cerulenin type Amide.
- Cerulenin type Chemical.
- Cerulenin type Ether.
- Cerulenin type Group.
- Cerulenin type Heterocycle.
- Cerulenin type Hydrocarbon.
- Cerulenin type Ketone.
- Cerulenin type ChemicalObject.
- Cerulenin type Thing.
- Cerulenin type Q11173.
- Cerulenin comment "Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1, another enzyme normally inhibited by malonyl-CoA.".
- Cerulenin label "Cerulenin".
- Cerulenin sameAs m.0bp_r1.
- Cerulenin sameAs Cerulenin.
- Cerulenin sameAs Cerulenin.
- Cerulenin sameAs Q5065296.
- Cerulenin sameAs Q5065296.
- Cerulenin wasDerivedFrom Cerulenin?oldid=670377762.
- Cerulenin depiction Cerulenin.svg.
- Cerulenin isPrimaryTopicOf Cerulenin.