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- Cerebral_blood_flow abstract "Cerebral blood flow (CBF) is the blood supply to the brain in a given period of time. In an adult, CBF is typically 750 millilitres per minute or 15% of the cardiac output. This equates to an average perfusion of 50 to 54 millilitres of blood per 100 grams of brain tissue per minute. CBF is tightly regulated to meet the brain's metabolic demands. Too much blood (a condition known as hyperemia) can raise intracranial pressure (ICP), which can compress and damage delicate brain tissue. Too little blood flow (ischemia) results if blood flow to the brain is below 18 to 20 ml per 100 g per minute, and tissue death occurs if flow dips below 8 to 10 ml per 100 g per minute. In brain tissue, a biochemical cascade known as the ischemic cascade is triggered when the tissue becomes ischemic, potentially resulting in damage to and the death of brain cells. Medical professionals must take steps to maintain proper CBF in patients who have conditions like shock, stroke, cerebral edema, and traumatic brain injury.Cerebral blood flow is determined by a number of factors, such as viscosity of blood, how dilated blood vessels are, and the net pressure of the flow of blood into the brain, known as cerebral perfusion pressure, which is determined by the body's blood pressure. Cerebral blood vessels are able to change the flow of blood through them by altering their diameters in a process called autoregulation; they constrict when systemic blood pressure is raised and dilate when it is lowered. Arterioles also constrict and dilate in response to different chemical concentrations. For example, they dilate in response to higher levels of carbon dioxide in the blood and constrict to lower levels of carbon dioxide.For example, assuming a person with an arterial partial pressure of carbon dioxide (PaCO2) of 40 mmHg (normal range of 38 - 42 mmHg) and a CBF of 50 ml per 100g per min. If the PaCO2 dips to 30 mmHg, this represents a 10 mmHg decrease from the initial value of PaCO2. Consequently, the CBF decreases by 1ml per 100g per min for each 1mmHg decrease in PaCO2, resulting in a new CBF of 40ml per 100g of brain tissue per minute. In fact, for each 1 mmHg increase or decrease in PaCO2, between the range of 20–60 mmHg, there is a corresponding CBF change in the same direction of approximately 1–2 ml/100g/min, or 2–5% of the CBF value. This is why small alterations in respiration pattern can cause significant changes in global CBF, specially through PaCO2 variations.CBF is equal to the cerebral perfusion pressure (CPP) divided by the cerebrovascular resistance (CVR):CBF = CPP / CVRControl of CBF is considered in terms of the factors affecting CPP and the factors affecting CVR. CVR is controlled by four major mechanisms: Metabolic control (or 'metabolic autoregulation') Pressure autoregulation Chemical control (by arterial pCO2 and pO2) Neural controlFunctional magnetic resonance imaging and positron emission tomography are neuroimaging techniques that can be used to measure CBF. These techniques are also used to measure regional CBF (rCBF) within a specific brain region.rCBF at one location can be measured over time by thermal diffusion".
- Cerebral_blood_flow wikiPageID "2995936".
- Cerebral_blood_flow wikiPageLength "6430".
- Cerebral_blood_flow wikiPageOutDegree "40".
- Cerebral_blood_flow wikiPageRevisionID "665838100".
- Cerebral_blood_flow wikiPageWikiLink Autoregulation.
- Cerebral_blood_flow wikiPageWikiLink Biochemical_cascade.
- Cerebral_blood_flow wikiPageWikiLink Blood_pressure.
- Cerebral_blood_flow wikiPageWikiLink Blood_vessel.
- Cerebral_blood_flow wikiPageWikiLink Brain.
- Cerebral_blood_flow wikiPageWikiLink Brain_cell.
- Cerebral_blood_flow wikiPageWikiLink Carbon_dioxide.
- Cerebral_blood_flow wikiPageWikiLink Cardiac_output.
- Cerebral_blood_flow wikiPageWikiLink Category:Cardiovascular_physiology.
- Cerebral_blood_flow wikiPageWikiLink Category:Neurology.
- Cerebral_blood_flow wikiPageWikiLink Cerebral_circulation.
- Cerebral_blood_flow wikiPageWikiLink Cerebral_edema.
- Cerebral_blood_flow wikiPageWikiLink Cerebral_perfusion_pressure.
- Cerebral_blood_flow wikiPageWikiLink Functional_magnetic_resonance_imaging.
- Cerebral_blood_flow wikiPageWikiLink Hyperaemia.
- Cerebral_blood_flow wikiPageWikiLink Hyperemia.
- Cerebral_blood_flow wikiPageWikiLink Interstitial_hydrostatic_pressure.
- Cerebral_blood_flow wikiPageWikiLink Intracranial_pressure.
- Cerebral_blood_flow wikiPageWikiLink Ischemia.
- Cerebral_blood_flow wikiPageWikiLink Ischemic_cascade.
- Cerebral_blood_flow wikiPageWikiLink Metabolic.
- Cerebral_blood_flow wikiPageWikiLink Metabolism.
- Cerebral_blood_flow wikiPageWikiLink Molecular_diffusion.
- Cerebral_blood_flow wikiPageWikiLink Nervous_system.
- Cerebral_blood_flow wikiPageWikiLink Neural.
- Cerebral_blood_flow wikiPageWikiLink Neuroimaging.
- Cerebral_blood_flow wikiPageWikiLink Neuron.
- Cerebral_blood_flow wikiPageWikiLink PCO2.
- Cerebral_blood_flow wikiPageWikiLink PaCO2.
- Cerebral_blood_flow wikiPageWikiLink Perfusion.
- Cerebral_blood_flow wikiPageWikiLink Perfusion_Scanning.
- Cerebral_blood_flow wikiPageWikiLink Perfusion_scanning.
- Cerebral_blood_flow wikiPageWikiLink Positron_emission_tomography.
- Cerebral_blood_flow wikiPageWikiLink Shock_(circulatory).
- Cerebral_blood_flow wikiPageWikiLink Starling_equation.
- Cerebral_blood_flow wikiPageWikiLink Stroke.
- Cerebral_blood_flow wikiPageWikiLink Traumatic_brain_injury.
- Cerebral_blood_flow wikiPageWikiLink Viscosity.
- Cerebral_blood_flow wikiPageWikiLinkText "CBF (cerebral blood flow)".
- Cerebral_blood_flow wikiPageWikiLinkText "Cerebral blood flow".
- Cerebral_blood_flow wikiPageWikiLinkText "arteries in the neck".
- Cerebral_blood_flow wikiPageWikiLinkText "blood flow to the brain".
- Cerebral_blood_flow wikiPageWikiLinkText "blood flow velocity".
- Cerebral_blood_flow wikiPageWikiLinkText "blood flow".
- Cerebral_blood_flow wikiPageWikiLinkText "cerebral blood circulation".
- Cerebral_blood_flow wikiPageWikiLinkText "cerebral blood flow (CBF)".
- Cerebral_blood_flow wikiPageWikiLinkText "cerebral blood flow".
- Cerebral_blood_flow wikiPageWikiLinkText "cerebral blood vessels".
- Cerebral_blood_flow wikiPageWikiLinkText "rCBF".
- Cerebral_blood_flow hasPhotoCollection Cerebral_blood_flow.
- Cerebral_blood_flow wikiPageUsesTemplate Template:Citation_broken.
- Cerebral_blood_flow wikiPageUsesTemplate Template:Merge_to.
- Cerebral_blood_flow subject Category:Cardiovascular_physiology.
- Cerebral_blood_flow subject Category:Neurology.
- Cerebral_blood_flow hypernym Supply.
- Cerebral_blood_flow type Ship.
- Cerebral_blood_flow type Specialty.
- Cerebral_blood_flow comment "Cerebral blood flow (CBF) is the blood supply to the brain in a given period of time. In an adult, CBF is typically 750 millilitres per minute or 15% of the cardiac output. This equates to an average perfusion of 50 to 54 millilitres of blood per 100 grams of brain tissue per minute. CBF is tightly regulated to meet the brain's metabolic demands. Too much blood (a condition known as hyperemia) can raise intracranial pressure (ICP), which can compress and damage delicate brain tissue.".
- Cerebral_blood_flow label "Cerebral blood flow".
- Cerebral_blood_flow sameAs معدل_جريان_الدم_في_الدماغ.
- Cerebral_blood_flow sameAs Zerebraler_Blutfluss.
- Cerebral_blood_flow sameAs Flujo_sanguíneo_cerebral.
- Cerebral_blood_flow sameAs Débit_sanguin_cérébral.
- Cerebral_blood_flow sameAs m.08jhb4.
- Cerebral_blood_flow sameAs Q5064096.
- Cerebral_blood_flow sameAs Q5064096.
- Cerebral_blood_flow wasDerivedFrom Cerebral_blood_flow?oldid=665838100.
- Cerebral_blood_flow isPrimaryTopicOf Cerebral_blood_flow.