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- Central_tolerance abstract "Central tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self. The concept of central tolerance was proposed in 1959 by Joshua Lederberg, as part of his general theory of immunity and tolerance, and is often mistakenly attributed to MacFarlane Burnet. Lederberg hypothesized that it is the age of the lymphocyte that defines whether an antigen that is encountered will induce tolerance, with immature lymphocytes being tolerance sensitive. Lederberg's theory that self-tolerance is 'learned' during lymphocyte development was a major conceptual contribution to immunology, and it was experimentally substantiated in the late 1980s when tools to analyze lymphocyte development became available. Central tolerance is distinct from peripheral tolerance in that it occurs while developing immune cells are still present in the primary lymphoid organs (the thymus and bone-marrow), prior to export into the periphery. Such peripheral tolerance is generated after the cells reach the periphery by regulatory T cells. Such regulatory T cells can be considered both central tolerance and peripheral tolerance mechanisms, as they can be generated from self(or foreign)-reactive T cells in the thymus (during T cell differentiation), but can also exert immune suppression in the periphery on other self(or foreign)-reactive T cells.".
- Central_tolerance wikiPageID "2911349".
- Central_tolerance wikiPageLength "12842".
- Central_tolerance wikiPageOutDegree "71".
- Central_tolerance wikiPageRevisionID "669155072".
- Central_tolerance wikiPageWikiLink AIRE.
- Central_tolerance wikiPageWikiLink APECED.
- Central_tolerance wikiPageWikiLink Anergic.
- Central_tolerance wikiPageWikiLink Anergy.
- Central_tolerance wikiPageWikiLink Antibodies.
- Central_tolerance wikiPageWikiLink Antibody.
- Central_tolerance wikiPageWikiLink Antigen.
- Central_tolerance wikiPageWikiLink Apoptosis.
- Central_tolerance wikiPageWikiLink Autoimmune_Regulator.
- Central_tolerance wikiPageWikiLink Autoimmune_polyendocrine_syndrome_type_1.
- Central_tolerance wikiPageWikiLink Autoimmune_regulator.
- Central_tolerance wikiPageWikiLink Autoimmunity.
- Central_tolerance wikiPageWikiLink B-cell_receptor.
- Central_tolerance wikiPageWikiLink B_cell.
- Central_tolerance wikiPageWikiLink B_cell_receptor.
- Central_tolerance wikiPageWikiLink Bone_marrow.
- Central_tolerance wikiPageWikiLink CD4.
- Central_tolerance wikiPageWikiLink CD4+.
- Central_tolerance wikiPageWikiLink CD8+_cell.
- Central_tolerance wikiPageWikiLink Category:Immunology.
- Central_tolerance wikiPageWikiLink Category:WikiProject_Molecular_and_Cellular_Biology_articles.
- Central_tolerance wikiPageWikiLink Central_tolerance.
- Central_tolerance wikiPageWikiLink Clonal_anergy.
- Central_tolerance wikiPageWikiLink Clonal_deletion.
- Central_tolerance wikiPageWikiLink Co-receptor.
- Central_tolerance wikiPageWikiLink Complementarity_determining_region.
- Central_tolerance wikiPageWikiLink Dendritic_cell.
- Central_tolerance wikiPageWikiLink Dendritic_cells.
- Central_tolerance wikiPageWikiLink Downregulate.
- Central_tolerance wikiPageWikiLink Downregulation_and_upregulation.
- Central_tolerance wikiPageWikiLink Drug_tolerance.
- Central_tolerance wikiPageWikiLink Exogenous_antigen.
- Central_tolerance wikiPageWikiLink Frank_Macfarlane_Burnet.
- Central_tolerance wikiPageWikiLink Immune_tolerance.
- Central_tolerance wikiPageWikiLink Immunoglobulin_D.
- Central_tolerance wikiPageWikiLink Immunoglobulin_M.
- Central_tolerance wikiPageWikiLink Immunology.
- Central_tolerance wikiPageWikiLink Insulin.
- Central_tolerance wikiPageWikiLink Joshua_Lederberg.
- Central_tolerance wikiPageWikiLink Junctional_diversity.
- Central_tolerance wikiPageWikiLink MHC_I.
- Central_tolerance wikiPageWikiLink MHC_II.
- Central_tolerance wikiPageWikiLink MHC_class_I.
- Central_tolerance wikiPageWikiLink MHC_class_II.
- Central_tolerance wikiPageWikiLink Major_histocompatibility_complex.
- Central_tolerance wikiPageWikiLink Negative_selection_(immunology).
- Central_tolerance wikiPageWikiLink Pathogen.
- Central_tolerance wikiPageWikiLink Peripheral_tolerance.
- Central_tolerance wikiPageWikiLink Polyvalent_antibody.
- Central_tolerance wikiPageWikiLink Receptor_editing.
- Central_tolerance wikiPageWikiLink Regulatory_T_cell.
- Central_tolerance wikiPageWikiLink Regulatory_T_cells.
- Central_tolerance wikiPageWikiLink Solubility.
- Central_tolerance wikiPageWikiLink Soluble.
- Central_tolerance wikiPageWikiLink T_cell.
- Central_tolerance wikiPageWikiLink T_cell_receptor.
- Central_tolerance wikiPageWikiLink Thymocyte.
- Central_tolerance wikiPageWikiLink Thymus.
- Central_tolerance wikiPageWikiLink V(D)J_recombination.
- Central_tolerance wikiPageWikiLinkText "Central tolerance".
- Central_tolerance wikiPageWikiLinkText "Central_tolerance".
- Central_tolerance wikiPageWikiLinkText "Negative selection".
- Central_tolerance wikiPageWikiLinkText "T cell tolerance".
- Central_tolerance wikiPageWikiLinkText "central selection".
- Central_tolerance wikiPageWikiLinkText "central tolerance".
- Central_tolerance wikiPageWikiLinkText "here".
- Central_tolerance wikiPageWikiLinkText "negative selection".
- Central_tolerance wikiPageWikiLinkText "tolerance".
- Central_tolerance wikiPageWikiLinkText "tolerant".
- Central_tolerance hasPhotoCollection Central_tolerance.
- Central_tolerance wikiPageUsesTemplate Template:Cleanup.
- Central_tolerance wikiPageUsesTemplate Template:Immune_system.
- Central_tolerance wikiPageUsesTemplate Template:Reflist.
- Central_tolerance wikiPageUsesTemplate Template:Use_dmy_dates.
- Central_tolerance subject Category:Immunology.
- Central_tolerance subject Category:WikiProject_Molecular_and_Cellular_Biology_articles.
- Central_tolerance hypernym Mechanism.
- Central_tolerance type Article.
- Central_tolerance type Organisation.
- Central_tolerance type Article.
- Central_tolerance type Page.
- Central_tolerance comment "Central tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self. The concept of central tolerance was proposed in 1959 by Joshua Lederberg, as part of his general theory of immunity and tolerance, and is often mistakenly attributed to MacFarlane Burnet. Lederberg hypothesized that it is the age of the lymphocyte that defines whether an antigen that is encountered will induce tolerance, with immature lymphocytes being tolerance sensitive.".
- Central_tolerance label "Central tolerance".
- Central_tolerance sameAs تحمل_مناعي_مركزي.
- Central_tolerance sameAs Centrální_tolerance.
- Central_tolerance sameAs Tolerancja_centralna.
- Central_tolerance sameAs Tolerância_central.
- Central_tolerance sameAs m.08c0sd.
- Central_tolerance sameAs Q606766.
- Central_tolerance sameAs Q606766.
- Central_tolerance wasDerivedFrom Central_tolerance?oldid=669155072.
- Central_tolerance isPrimaryTopicOf Central_tolerance.