Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Cebranopadol> ?p ?o }
- Cebranopadol abstract "Cebranopadol (GRT-6005) is a novel opioid analgesic of the benzenoid class which is currently under development internationally by Grünenthal, a German pharmaceutical company, and its partner Forest Laboratories, a pharmaceutical company in the United States, for the treatment of a variety of different acute and chronic pain states. As of November 2014, it is in phase III clinical trials. Cebranopadol is unique in its mechanism of action as an opioid, binding to and activating all four of the opioid receptors; it acts as a full agonist of the nociceptin receptor (Ki = 0.9 nM; EC50 = 13.0; IA = 89%), μ-opioid receptor (Ki = 0.7 nM; EC50 = 1.2; IA = 104%), and δ-opioid receptor (Ki = 18 nM; EC50 = 110; IA = 105%), and as a partial agonist of the κ-opioid receptor (Ki = 2.6 nM; EC50 = 17; IA = 67%). The ED50 values of 0.5-5.6 µg/kg when introduced IV & 25.1 µg/kg after oral administration.Cebranopadol shows highly potent and effective antinociceptive and antihypertensive effects in a variety of different animal models of pain. Notably, it has also been found to be more potent in models of chronic neuropathic pain than acute nociceptive pain compared to selective μ-opioid receptor agonists. Relative to morphine, tolerance to the analgesic effects of cebranopadol has been found to be delayed (26 days versus 11 days for complete tolerance). In addition, unlike morphine, cebranopadol has not been found to affect motor coordination or reduce respiration in animals at doses in or over the dosage range for analgesia. As such, it may have improved and prolonged efficaciousness and greater tolerability in comparison to currently available opioid analgesics.As an agonist of the κ-opioid receptor, cebranopadol may have the capacity to produce psychotomimetic effects and other adverse reactions at sufficiently high doses, a property which could potentially limit its practical clinical dosage range.".
- Cebranopadol atcPrefix "None".
- Cebranopadol casNumber "863513-91-1".
- Cebranopadol iupacName "(1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4-b]indol]-4-amine".
- Cebranopadol pubchem "11848225".
- Cebranopadol thumbnail Cebranopadol_structure.png?width=300.
- Cebranopadol wikiPageExternalLink results?term=cebranopadol&Search=Search.
- Cebranopadol wikiPageExternalLink 265600020.jsp.
- Cebranopadol wikiPageID "44629722".
- Cebranopadol wikiPageLength "6288".
- Cebranopadol wikiPageOutDegree "43".
- Cebranopadol wikiPageRevisionID "683172624".
- Cebranopadol wikiPageWikiLink AT-076.
- Cebranopadol wikiPageWikiLink Adverse_effect.
- Cebranopadol wikiPageWikiLink Adverse_reaction.
- Cebranopadol wikiPageWikiLink Agonist.
- Cebranopadol wikiPageWikiLink Analgesic.
- Cebranopadol wikiPageWikiLink Animal_model.
- Cebranopadol wikiPageWikiLink Antihypertensive.
- Cebranopadol wikiPageWikiLink Antihypertensive_drug.
- Cebranopadol wikiPageWikiLink Antinociceptive.
- Cebranopadol wikiPageWikiLink Category:Analgesics.
- Cebranopadol wikiPageWikiLink Category:Delta-opioid_agonists.
- Cebranopadol wikiPageWikiLink Category:Kappa_agonists.
- Cebranopadol wikiPageWikiLink Category:Mu-opioid_agonists.
- Cebranopadol wikiPageWikiLink Category:Nociceptin_receptor_agonists.
- Cebranopadol wikiPageWikiLink Category:Opioids.
- Cebranopadol wikiPageWikiLink Chronic_pain.
- Cebranopadol wikiPageWikiLink Clinical_trial.
- Cebranopadol wikiPageWikiLink Drug_tolerance.
- Cebranopadol wikiPageWikiLink EC50.
- Cebranopadol wikiPageWikiLink Efficacy.
- Cebranopadol wikiPageWikiLink Etorphine.
- Cebranopadol wikiPageWikiLink Forest_Laboratories.
- Cebranopadol wikiPageWikiLink Full_agonist.
- Cebranopadol wikiPageWikiLink Germany.
- Cebranopadol wikiPageWikiLink Grünenthal.
- Cebranopadol wikiPageWikiLink Grünenthal_GmbH.
- Cebranopadol wikiPageWikiLink Intrinsic_activity.
- Cebranopadol wikiPageWikiLink Mechanism_of_action.
- Cebranopadol wikiPageWikiLink Mitragynine.
- Cebranopadol wikiPageWikiLink Model_organism.
- Cebranopadol wikiPageWikiLink Motor_coordination.
- Cebranopadol wikiPageWikiLink Neuropathic_pain.
- Cebranopadol wikiPageWikiLink Nociceptin_receptor.
- Cebranopadol wikiPageWikiLink Nociception.
- Cebranopadol wikiPageWikiLink Nociceptive_pain.
- Cebranopadol wikiPageWikiLink Norbuprenorphine.
- Cebranopadol wikiPageWikiLink Opioid.
- Cebranopadol wikiPageWikiLink Opioid_receptor.
- Cebranopadol wikiPageWikiLink Pain.
- Cebranopadol wikiPageWikiLink Partial_agonist.
- Cebranopadol wikiPageWikiLink Pharmaceutical_company.
- Cebranopadol wikiPageWikiLink Pharmaceutical_industry.
- Cebranopadol wikiPageWikiLink Phase_III.
- Cebranopadol wikiPageWikiLink Phases_of_clinical_research.
- Cebranopadol wikiPageWikiLink Psychotomimetic.
- Cebranopadol wikiPageWikiLink Respiration_(physiology).
- Cebranopadol wikiPageWikiLink Tolerability.
- Cebranopadol wikiPageWikiLink United_States.
- Cebranopadol wikiPageWikiLink Δ-opioid_receptor.
- Cebranopadol wikiPageWikiLink Κ-opioid_receptor.
- Cebranopadol wikiPageWikiLink Μ-opioid_receptor.
- Cebranopadol wikiPageWikiLinkText "Cebranopadol".
- Cebranopadol atcPrefix "None".
- Cebranopadol casNumber "863513".
- Cebranopadol chemicalFormula "C24H27FN2O".
- Cebranopadol chemspiderid "29398942".
- Cebranopadol eliminationHalfLife "16200.0".
- Cebranopadol hasPhotoCollection Cebranopadol.
- Cebranopadol inchi "1".
- Cebranopadol inchikey "CSMVOZKEWSOFER-RQNOJGIXBU".
- Cebranopadol iupacName "-6".
- Cebranopadol molecularWeight "378.482".
- Cebranopadol pubchem "11848225".
- Cebranopadol smiles "CNC".
- Cebranopadol stdinchi "1".
- Cebranopadol stdinchikey "CSMVOZKEWSOFER-RQNOJGIXSA-N".
- Cebranopadol wikiPageUsesTemplate Template:Analgesics.
- Cebranopadol wikiPageUsesTemplate Template:Drugbox.
- Cebranopadol wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Cebranopadol wikiPageUsesTemplate Template:Opioidergics.
- Cebranopadol wikiPageUsesTemplate Template:Reflist.
- Cebranopadol subject Category:Analgesics.
- Cebranopadol subject Category:Delta-opioid_agonists.
- Cebranopadol subject Category:Kappa_agonists.
- Cebranopadol subject Category:Mu-opioid_agonists.
- Cebranopadol subject Category:Nociceptin_receptor_agonists.
- Cebranopadol subject Category:Opioids.
- Cebranopadol hypernym Opioid.
- Cebranopadol type ChemicalSubstance.
- Cebranopadol type Drug.
- Cebranopadol type ChemicalObject.
- Cebranopadol type Thing.
- Cebranopadol type Q8386.
- Cebranopadol comment "Cebranopadol (GRT-6005) is a novel opioid analgesic of the benzenoid class which is currently under development internationally by Grünenthal, a German pharmaceutical company, and its partner Forest Laboratories, a pharmaceutical company in the United States, for the treatment of a variety of different acute and chronic pain states. As of November 2014, it is in phase III clinical trials.".
- Cebranopadol label "Cebranopadol".
- Cebranopadol sameAs m.012fx0b8.
- Cebranopadol sameAs Q19596315.
- Cebranopadol sameAs Q19596315.