Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Cathepsin_D> ?p ?o }
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- Cathepsin_D abstract "Cathepsin D is a protein that in humans is encoded by the CTSD gene.This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.It has been used as a breast cancer tumor marker.Cathepsin-D is an aspartic protease that depends critically on protonation of its active site Asp residue and gets activated at pH 5 in endosome of hepatocytes where it degrades insulin. Along with Asp-protonation, lower pH also leads to conformational switch in cathepsin-D : the N terminal segment of the protease moves out of the active site as pH drops. Ceramide binds-to and activates cathepsin D.".
- Cathepsin_D entrezgene "1509".
- Cathepsin_D wikiPageExternalLink merops.cgi?id=A01.009.
- Cathepsin_D wikiPageExternalLink br.fcgi?book=gene&part=ncl.
- Cathepsin_D wikiPageID "14722632".
- Cathepsin_D wikiPageLength "10152".
- Cathepsin_D wikiPageOutDegree "14".
- Cathepsin_D wikiPageRevisionID "659865843".
- Cathepsin_D wikiPageWikiLink Breast_cancer.
- Cathepsin_D wikiPageWikiLink Category:Peptidase.
- Cathepsin_D wikiPageWikiLink Ceramide.
- Cathepsin_D wikiPageWikiLink Endosome.
- Cathepsin_D wikiPageWikiLink Gene.
- Cathepsin_D wikiPageWikiLink Hepatocyte.
- Cathepsin_D wikiPageWikiLink Hepatocytes.
- Cathepsin_D wikiPageWikiLink Insulin.
- Cathepsin_D wikiPageWikiLink Lysosome.
- Cathepsin_D wikiPageWikiLink MEROPS.
- Cathepsin_D wikiPageWikiLink Pepsin.
- Cathepsin_D wikiPageWikiLink Protease.
- Cathepsin_D wikiPageWikiLink Protein.
- Cathepsin_D wikiPageWikiLink Protein_dimer.
- Cathepsin_D wikiPageWikiLink Tumor_marker.
- Cathepsin_D wikiPageWikiLinkText "Cathepsin D".
- Cathepsin_D wikiPageWikiLinkText "D".
- Cathepsin_D wikiPageWikiLinkText "cathepsin D".
- Cathepsin_D hasPhotoCollection Cathepsin_D.
- Cathepsin_D requireManualInspection "no".
- Cathepsin_D summaryText "This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.".
- Cathepsin_D updateCitations "yes".
- Cathepsin_D updatePage "yes".
- Cathepsin_D updateProteinBox "yes".
- Cathepsin_D updateSummary "yes".
- Cathepsin_D wikiPageUsesTemplate Template:Aspartic_acid_proteases.
- Cathepsin_D wikiPageUsesTemplate Template:Gene-11-stub.
- Cathepsin_D wikiPageUsesTemplate Template:PBB.
- Cathepsin_D wikiPageUsesTemplate Template:PBB_Controls.
- Cathepsin_D wikiPageUsesTemplate Template:PBB_Further_reading.
- Cathepsin_D wikiPageUsesTemplate Template:PBB_Summary.
- Cathepsin_D wikiPageUsesTemplate Template:PDB_Gallery.
- Cathepsin_D wikiPageUsesTemplate Template:Refbegin.
- Cathepsin_D wikiPageUsesTemplate Template:Refend.
- Cathepsin_D wikiPageUsesTemplate Template:Reflist.
- Cathepsin_D wikiPageUsesTemplate Template:Tumor_markers.
- Cathepsin_D subject Category:Peptidase.
- Cathepsin_D hypernym Protein.
- Cathepsin_D type Biomolecule.
- Cathepsin_D type Protein.
- Cathepsin_D type Thing.
- Cathepsin_D type Q206229.
- Cathepsin_D type Q8054.
- Cathepsin_D comment "Cathepsin D is a protein that in humans is encoded by the CTSD gene.This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript.".
- Cathepsin_D label "Cathepsin D".
- Cathepsin_D sameAs Catepsina_D.
- Cathepsin_D sameAs m.03gvj98.
- Cathepsin_D sameAs Katepsin-D.
- Cathepsin_D sameAs Katepsin-D.
- Cathepsin_D sameAs Q3663475.
- Cathepsin_D sameAs Q3663475.
- Cathepsin_D wasDerivedFrom Cathepsin_D?oldid=659865843.
- Cathepsin_D isPrimaryTopicOf Cathepsin_D.