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- Catastrophic_antiphospholipid_syndrome abstract "Catastrophic antiphospholipid syndrome, CAPS, also known as Asherson’s syndrome, is an acute and complex biological process that leads to occlusion of small vessels of various organs. It was first described by Ronald Asherson in 1992. The syndrome exhibits thrombotic microangiopathy, multiple organ thrombosis, and in some cases tissue necrosis and is considered an extreme or catastrophic variant of the antiphospholipid syndrome.CAPS has a mortality rate of about 50%. With the establishment of a CAPS-Registry more has been learned about this syndrome, but its cause remains unknown. Infection, trauma, medication, or surgery can be identified in about half the cases as a “trigger”. It is thought that cytokines are activated leading to a cytokine storm with the potentially fatal consequences of organ failure. A low platelet count is a common finding. Individuals with CAPS often exhibit a positive test to antilipid antibodies, typically IgG, and may or may not have a history of lupus or another connective tissue disease Association with another disease such as lupus is called a secondary APS unless it includes the defining criteria for CAPS. Clinically, the syndrome affects at least three organs and may affect many organs systems. Peripheral thrombosis may be encountered affecting veins and arteries. Intraabdominal thrombosis may lead to pain. Cardiovascular, nervous, kidney, and lung system complications are common. The affected individual may exhibit skin purpura and necrosis. Cerebral manifestations may lead to encephalopathy and seizures. Myocardial infarctions may occur. Strokes may occur due to the arterial clotting involvement. Death may result from multiple organ failure. Treatments may involve the following steps: Prevention includes the use of antibiotics for infection and parenteral anticoagulation for susceptible patients. Specific therapy includes the use of intravenous heparin and corticosteroids, and possibly plasma exchanges, intravenous immunoglobulin. Additional steps may have to be taken to manage circulatory problems, kidney failure, and respiratory distress. When maintaining survival of the disease treatments also include high doses of Rituxan (Rituximab)to maintain stability.↑".
- Catastrophic_antiphospholipid_syndrome wikiPageExternalLink caps.htm.
- Catastrophic_antiphospholipid_syndrome wikiPageExternalLink overview.htm.
- Catastrophic_antiphospholipid_syndrome wikiPageExternalLink CAPS.HTM.
- Catastrophic_antiphospholipid_syndrome wikiPageExternalLink science?_ob=ArticleURL&_udi=B6W8V-4CBVKKG-2&_coverDate=01%2F31%2F2005&_alid=397431141&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6664&_sort=d&view=c&_acct=C000038338&_version=1&_urlVersion=0&_userid=687471&md5=df6944c453861d62c65c9aca0aa0e5b9.
- Catastrophic_antiphospholipid_syndrome wikiPageID "4983663".
- Catastrophic_antiphospholipid_syndrome wikiPageLength "3394".
- Catastrophic_antiphospholipid_syndrome wikiPageOutDegree "28".
- Catastrophic_antiphospholipid_syndrome wikiPageRevisionID "655229522".
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Acute_(medical).
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Acute_(medicine).
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Antibiotic.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Antibiotics.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Antibody.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Anticoagulant.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Anticoagulation.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Antiphospholipid_syndrome.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Category:Intensive_care_medicine.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Category:Rheumatology.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Connective_tissue_disease.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Corticosteroid.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Cytokine_storm.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Encephalopathy.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Epileptic_seizure.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Extreme_value.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Heparin.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Immunoglobulin.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Kidney_failure.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Lupus_erythematosus.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Maxima_and_minima.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Microangiopathy.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Multiple_organ_thrombosis.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Myocardial_infarction.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Necrosis.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Plasma_exchange.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Plasmapheresis.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Purpura.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Renal_failure.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Respiratory_distress.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Ronald_Asherson.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Seizure.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Stroke.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Thrombocytopenia.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Thrombosis.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Tissue_necrosis.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLink Vascular_occlusion.
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLinkText "CAPS".
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLinkText "Catastrophic antiphospholipid syndrome".
- Catastrophic_antiphospholipid_syndrome wikiPageWikiLinkText "catastrophic antiphospholipid syndrome".
- Catastrophic_antiphospholipid_syndrome hasPhotoCollection Catastrophic_antiphospholipid_syndrome.
- Catastrophic_antiphospholipid_syndrome subject Category:Intensive_care_medicine.
- Catastrophic_antiphospholipid_syndrome subject Category:Rheumatology.
- Catastrophic_antiphospholipid_syndrome hypernym Process.
- Catastrophic_antiphospholipid_syndrome type Election.
- Catastrophic_antiphospholipid_syndrome type Specialty.
- Catastrophic_antiphospholipid_syndrome comment "Catastrophic antiphospholipid syndrome, CAPS, also known as Asherson’s syndrome, is an acute and complex biological process that leads to occlusion of small vessels of various organs. It was first described by Ronald Asherson in 1992. The syndrome exhibits thrombotic microangiopathy, multiple organ thrombosis, and in some cases tissue necrosis and is considered an extreme or catastrophic variant of the antiphospholipid syndrome.CAPS has a mortality rate of about 50%.".
- Catastrophic_antiphospholipid_syndrome label "Catastrophic antiphospholipid syndrome".
- Catastrophic_antiphospholipid_syndrome sameAs Síndrome_antifosfolípidos_catastrófico.
- Catastrophic_antiphospholipid_syndrome sameAs Katastroficzny_zespół_antyfosfolipidowy.
- Catastrophic_antiphospholipid_syndrome sameAs m.0cyg53.
- Catastrophic_antiphospholipid_syndrome sameAs Q5051580.
- Catastrophic_antiphospholipid_syndrome sameAs Q5051580.
- Catastrophic_antiphospholipid_syndrome wasDerivedFrom Catastrophic_antiphospholipid_syndrome?oldid=655229522.
- Catastrophic_antiphospholipid_syndrome isPrimaryTopicOf Catastrophic_antiphospholipid_syndrome.