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- Carcinosarcoma abstract "Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer). Carcinosarcomas are rare tumors, and can arise in diverse organs, such as the skin, salivary glands, lungs, the esophagus, pancreas, colon, uterus and ovaries.Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely on the pathology of the disease. First, the collision tumor hypothesis, which proposes the collision of two independent tumors resulting in a single neoplasm, based on the observation that skin cancers and superficial malignant fibrous histiocytomas are commonly seen in patients with sun-damaged skin; second, the composition hypothesis, which suggests that the mesenchymal component represents a pseudosarcomatous reaction to the epithelial malignancy; third, the combination hypothesis, which suggests that both the epithelial and mesenchymal components of the tumor arise from a common pluripotential stem cell that undergoes divergent differentiation; and fourth, the conversion/divergence hypothesis, which argues that the sarcomatous component of the tumor represents a metaplastic sarcomatous transformation of the epithelial component. Despite the remaining uncertainty on the mechanisms that generate these tumors, recent immunohistochemical, ultrastructural, and molecular genetic studies suggest and favor the notion of monoclonality in carcinosarcoma. In addition, identical p53 and KRAS mutations have been identified in both epithelial and mesenchymal components of carcinosarcoma, findings that suggest an early alteration in the histogenesis of the tumor with late transformation or degeneration of the epithelial component into the sarcomatous component.".
- Carcinosarcoma meshId "D002296".
- Carcinosarcoma thumbnail Carcinosarcoma_-_2_-_intermed_mag.jpg?width=300.
- Carcinosarcoma wikiPageExternalLink dictionary?CdrID=44003.
- Carcinosarcoma wikiPageID "14417945".
- Carcinosarcoma wikiPageLength "5548".
- Carcinosarcoma wikiPageOutDegree "29".
- Carcinosarcoma wikiPageRevisionID "674549347".
- Carcinosarcoma wikiPageWikiLink Adenosarcoma.
- Carcinosarcoma wikiPageWikiLink Cancer.
- Carcinosarcoma wikiPageWikiLink Carcinoma.
- Carcinosarcoma wikiPageWikiLink Category:Rare_diseases.
- Carcinosarcoma wikiPageWikiLink Category:Sarcoma.
- Carcinosarcoma wikiPageWikiLink Connective_tissue.
- Carcinosarcoma wikiPageWikiLink Epithelial.
- Carcinosarcoma wikiPageWikiLink Epithelium.
- Carcinosarcoma wikiPageWikiLink Esophagus.
- Carcinosarcoma wikiPageWikiLink H&E_stain.
- Carcinosarcoma wikiPageWikiLink Histogenesis.
- Carcinosarcoma wikiPageWikiLink KRAS.
- Carcinosarcoma wikiPageWikiLink Large_intestine.
- Carcinosarcoma wikiPageWikiLink Lung.
- Carcinosarcoma wikiPageWikiLink Malignant_fibrous_histiocytoma.
- Carcinosarcoma wikiPageWikiLink Malignant_tumor.
- Carcinosarcoma wikiPageWikiLink Mesenchymal.
- Carcinosarcoma wikiPageWikiLink Mesenchyme.
- Carcinosarcoma wikiPageWikiLink Metaplasia.
- Carcinosarcoma wikiPageWikiLink Micrograph.
- Carcinosarcoma wikiPageWikiLink Mutation.
- Carcinosarcoma wikiPageWikiLink Neoplasm.
- Carcinosarcoma wikiPageWikiLink Ovaries.
- Carcinosarcoma wikiPageWikiLink Ovary.
- Carcinosarcoma wikiPageWikiLink P53.
- Carcinosarcoma wikiPageWikiLink Pancreas.
- Carcinosarcoma wikiPageWikiLink Pleomorphic_undifferentiated_sarcoma.
- Carcinosarcoma wikiPageWikiLink Salivary_gland.
- Carcinosarcoma wikiPageWikiLink Sarcoma.
- Carcinosarcoma wikiPageWikiLink Skin.
- Carcinosarcoma wikiPageWikiLink Skin_cancer.
- Carcinosarcoma wikiPageWikiLink Stem_cell.
- Carcinosarcoma wikiPageWikiLink Uterine_adenosarcoma.
- Carcinosarcoma wikiPageWikiLink Uterus.
- Carcinosarcoma wikiPageWikiLinkText "Carcinosarcoma".
- Carcinosarcoma wikiPageWikiLinkText "carcinosarcoma".
- Carcinosarcoma caption "Micrograph of a carcinosarcoma. H&E stain.".
- Carcinosarcoma hasPhotoCollection Carcinosarcoma.
- Carcinosarcoma meshid "D002296".
- Carcinosarcoma name "Carcinosarcoma".
- Carcinosarcoma width "250".
- Carcinosarcoma wikiPageUsesTemplate Template:Infobox_disease.
- Carcinosarcoma wikiPageUsesTemplate Template:NCI-cancer-dict.
- Carcinosarcoma wikiPageUsesTemplate Template:Reflist.
- Carcinosarcoma wikiPageUsesTemplate Template:Soft_tissue_tumors_and_sarcomas.
- Carcinosarcoma subject Category:Rare_diseases.
- Carcinosarcoma subject Category:Sarcoma.
- Carcinosarcoma hypernym Tumors.
- Carcinosarcoma type Article.
- Carcinosarcoma type Disease.
- Carcinosarcoma type Article.
- Carcinosarcoma type Institute.
- Carcinosarcoma type Source.
- Carcinosarcoma type Thing.
- Carcinosarcoma type Q12136.
- Carcinosarcoma comment "Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer). Carcinosarcomas are rare tumors, and can arise in diverse organs, such as the skin, salivary glands, lungs, the esophagus, pancreas, colon, uterus and ovaries.Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely on the pathology of the disease.".
- Carcinosarcoma label "Carcinosarcoma".
- Carcinosarcoma sameAs Carcinosarcome.
- Carcinosarcoma sameAs Carcinossarcoma.
- Carcinosarcoma sameAs m.03d2xqh.
- Carcinosarcoma sameAs Q5038170.
- Carcinosarcoma sameAs Q5038170.
- Carcinosarcoma sameAs 癌肉瘤.
- Carcinosarcoma wasDerivedFrom Carcinosarcoma?oldid=674549347.
- Carcinosarcoma depiction Carcinosarcoma_-_2_-_intermed_mag.jpg.
- Carcinosarcoma isPrimaryTopicOf Carcinosarcoma.
- Carcinosarcoma name "Carcinosarcoma".