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- Carbonic_anhydrase_9 abstract "Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene.Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CAIX is a transmembrane protein and is a tumor-associated carbonic anhydrase isoenzyme. It is over-expressed in VHL mutated clear-cell renal cell carcinoma (ccRCC) and hypoxic solid tumors, but is low-expressed in normal kidney and most other normal tissues. It may be involved in cell proliferation and transformation. This gene is mapped to 9p13-p12.CAIX has been licensed by the Dendreon Corporation. It is under development as a target for Autologous Cellular Immunotherapy. Product candidates targeted at CA9 are in preclinical development for the treatment of kidney, colon, and cervical cancer.CAIX is considered to be one of the best cellular biomarkers of hypoxia. Furthermore, recent studies examining the association between CAIX levels and various clinicopathological outcomes suggest that CAIX expression may also be a valuable prognostic indicator for overall survival. Antibodies against CAIX serve as excellent biomarkers of hypoxic regions in many solid tumors.".
- Carbonic_anhydrase_9 entrezgene "768".
- Carbonic_anhydrase_9 wikiPageID "14723611".
- Carbonic_anhydrase_9 wikiPageLength "9587".
- Carbonic_anhydrase_9 wikiPageOutDegree "4".
- Carbonic_anhydrase_9 wikiPageRevisionID "678904597".
- Carbonic_anhydrase_9 wikiPageWikiLink Carbonic_anhydrase.
- Carbonic_anhydrase_9 wikiPageWikiLink Enzyme.
- Carbonic_anhydrase_9 wikiPageWikiLink Gene.
- Carbonic_anhydrase_9 wikiPageWikiLink VHL.
- Carbonic_anhydrase_9 wikiPageWikiLink Von_Hippel–Lindau_tumor_suppressor.
- Carbonic_anhydrase_9 wikiPageWikiLinkText "CA-IX".
- Carbonic_anhydrase_9 wikiPageWikiLinkText "Carbonic anhydrase 9".
- Carbonic_anhydrase_9 wikiPageWikiLinkText "carbonic anhydrase 9".
- Carbonic_anhydrase_9 hasPhotoCollection Carbonic_anhydrase_9.
- Carbonic_anhydrase_9 requireManualInspection "no".
- Carbonic_anhydrase_9 summaryText "Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CAIX is a transmembrane protein and is a tumor-associated carbonic anhydrase isoenzyme. It is over-expressed in VHL mutated clear-cell renal cell carcinoma and hypoxic solid tumors, but is low-expressed in normal kidney and most other normal tissues. It may be involved in cell proliferation and transformation. This gene is mapped to 9p13-p12. CAIX has been licensed by the Dendreon Corporation. It is under development as a target for Autologous Cellular Immunotherapy. Product candidates targeted at CA9 are in preclinical development for the treatment of kidney, colon, and cervical cancer. CAIX is considered to be one of the best cellular biomarkers of hypoxia. Furthermore, recent studies examining the association between CAIX levels and various clinicopathological outcomes suggest that CAIX expression may also be a valuable prognostic indicator for overall survival. Antibodies against CAIX serve as excellent biomarkers of hypoxic regions in many solid tumors.".
- Carbonic_anhydrase_9 updateCitations "yes".
- Carbonic_anhydrase_9 updatePage "yes".
- Carbonic_anhydrase_9 updateProteinBox "yes".
- Carbonic_anhydrase_9 updateSummary "yes".
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:Carbonic_anhydrases.
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:Gene-9-stub.
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:PBB.
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:PBB_Controls.
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:PBB_Further_reading.
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:PBB_Summary.
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:Redirect.
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:Refbegin.
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:Refend.
- Carbonic_anhydrase_9 wikiPageUsesTemplate Template:Reflist.
- Carbonic_anhydrase_9 hypernym Enzyme.
- Carbonic_anhydrase_9 type Biomolecule.
- Carbonic_anhydrase_9 type Protein.
- Carbonic_anhydrase_9 type Thing.
- Carbonic_anhydrase_9 type Q206229.
- Carbonic_anhydrase_9 type Q8054.
- Carbonic_anhydrase_9 comment "Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene.Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.".
- Carbonic_anhydrase_9 label "Carbonic anhydrase 9".
- Carbonic_anhydrase_9 sameAs m.03gvl81.
- Carbonic_anhydrase_9 sameAs Q5038045.
- Carbonic_anhydrase_9 sameAs Q5038045.
- Carbonic_anhydrase_9 wasDerivedFrom Carbonic_anhydrase_9?oldid=678904597.
- Carbonic_anhydrase_9 isPrimaryTopicOf Carbonic_anhydrase_9.