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- CXCL3 abstract "Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates its effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of cerebellum. Moreover, if the expression of Cxcl3 is reduced in cerebellar granule neuron precursors, this highly enhances the frequency of the medulloblastoma, the tumor of cerebellum. In fact, the reduced expression of Cxcl3 forces the cerebellar granule neuron precursors to remain at the surface of the cerebellum, where they highly proliferate under the stimulus of Sonic hedgehog, becoming target of transforming insults. Remarkably, the treatment with CXCL3 reduces the area of medulloblastoma lesions in a mouse model of medulloblastoma. Thus, CXCL3 is a potential target for medulloblastoma therapy. Cxcl3 is directly regulated transcriptionally by BTG2 The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.".
- CXCL3 entrezgene "2921".
- CXCL3 wikiPageID "8813712".
- CXCL3 wikiPageLength "3316".
- CXCL3 wikiPageOutDegree "12".
- CXCL3 wikiPageRevisionID "593922475".
- CXCL3 wikiPageWikiLink BTG2.
- CXCL3 wikiPageWikiLink CXC_chemokine_receptors.
- CXCL3 wikiPageWikiLink Category:Cytokines.
- CXCL3 wikiPageWikiLink Cell_adhesion.
- CXCL3 wikiPageWikiLink Cerebellum.
- CXCL3 wikiPageWikiLink Chemokine.
- CXCL3 wikiPageWikiLink Chemokine_receptor.
- CXCL3 wikiPageWikiLink Chemotaxis.
- CXCL3 wikiPageWikiLink Chromosome_4.
- CXCL3 wikiPageWikiLink Chromosome_4_(human).
- CXCL3 wikiPageWikiLink Cytokine.
- CXCL3 wikiPageWikiLink Monocyte.
- CXCL3 wikiPageWikiLink Sonic_hedgehog.
- CXCL3 wikiPageWikiLinkText "CXCL3".
- CXCL3 hasPhotoCollection CXCL3.
- CXCL3 wikiPageUsesTemplate Template:Chemokines.
- CXCL3 wikiPageUsesTemplate Template:Gene-4-stub.
- CXCL3 wikiPageUsesTemplate Template:PBB.
- CXCL3 wikiPageUsesTemplate Template:Reflist.
- CXCL3 subject Category:Cytokines.
- CXCL3 hypernym Cytokine.
- CXCL3 type Biomolecule.
- CXCL3 type Protein.
- CXCL3 type Thing.
- CXCL3 type Q206229.
- CXCL3 type Q8054.
- CXCL3 comment "Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates its effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2.".
- CXCL3 label "CXCL3".
- CXCL3 sameAs m.027kp5f.
- CXCL3 sameAs CXCL3.
- CXCL3 sameAs CXCL3.
- CXCL3 sameAs Q5014888.
- CXCL3 sameAs Q5014888.
- CXCL3 wasDerivedFrom CXCL3?oldid=593922475.
- CXCL3 isPrimaryTopicOf CXCL3.