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- COX-inhibiting_nitric_oxide_donator abstract "COX-inhibiting nitric oxide donators (CINODs), also known as NO-NSAIDs, are a new class of non-steroidal anti-inflammatory drug (NSAID) developed with the intention of providing greater safety than existing NSAIDs.These compounds were first described by John Wallace and colleagues. CINODs are compounds generated by the fusion of an existing NSAID with a nitric oxide (NO)-donating moiety by chemical means, usually by ester linkage. CINODs retain the anti-inflammatory efficacy of NSAIDs via inhibition of cyclooxygenase (COX) while arguably improving upon gastric and vascular safety, most likely via vasorelaxation, inhibition of leukocyte adhesion and inhibition of caspases, all known effects of NO. The first CINODs were developed in the 1990s, and as yet none have been approved for use by the general public. The importance of developing such drugs was increased when COX-2-specific NSAIDs rofecoxib (Vioxx) and lumiracoxib (Prexige) were removed from major pharmaceutical markets in the mid-2000s due to vascular safety concerns. In addition, traditional NSAIDs increase blood pressure and interfere with the actions of antihypertensive drugs. Several CINODs are currently being tested in clinical trials, the most advanced of which are being conducted by the French pharmaceutical company NicOx, whose flagship compound naproxcinod (NO-naproxen, nitronaproxen) is in phase III trials for the treatment of osteoarthritis. Naproxcinod is a fusion of naproxen and a NO-donating group. Other CINODs are also being tested by NicOx for the treatment of diseases in which inflammation plays a role.".
- COX-inhibiting_nitric_oxide_donator wikiPageID "14911980".
- COX-inhibiting_nitric_oxide_donator wikiPageLength "3721".
- COX-inhibiting_nitric_oxide_donator wikiPageOutDegree "26".
- COX-inhibiting_nitric_oxide_donator wikiPageRevisionID "621230351".
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Anti-inflammatory.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Antihypertensive.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Antihypertensive_drug.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Blood_pressure.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink COX-2_inhibitor.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Caspase.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Caspases.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Category:Non-steroidal_anti-inflammatory_drugs.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Cell_adhesion.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Chemical_compound.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Clinical_trial.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Clinical_trials.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Cyclooxygenase.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Ester.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink France.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Functional_group.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Leukocyte.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Lumiracoxib.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Naproxcinod.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Naproxen.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink NicOx.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Nitric_oxide.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Non-steroidal_anti-inflammatory_drug.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Nonsteroidal_anti-inflammatory_drug.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Osteoarthritis.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Pharmaceutical_company.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Pharmaceutical_industry.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Rofecoxib.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Vasodilation.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink Vasorelaxation.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLink White_blood_cell.
- COX-inhibiting_nitric_oxide_donator wikiPageWikiLinkText "COX-inhibiting nitric oxide donator".
- COX-inhibiting_nitric_oxide_donator hasPhotoCollection COX-inhibiting_nitric_oxide_donator.
- COX-inhibiting_nitric_oxide_donator wikiPageUsesTemplate Template:Analgesic-stub.
- COX-inhibiting_nitric_oxide_donator wikiPageUsesTemplate Template:Analgesics.
- COX-inhibiting_nitric_oxide_donator wikiPageUsesTemplate Template:NSAIDs.
- COX-inhibiting_nitric_oxide_donator wikiPageUsesTemplate Template:Reflist.
- COX-inhibiting_nitric_oxide_donator subject Category:Non-steroidal_anti-inflammatory_drugs.
- COX-inhibiting_nitric_oxide_donator hypernym Class.
- COX-inhibiting_nitric_oxide_donator type Agent.
- COX-inhibiting_nitric_oxide_donator type Drug.
- COX-inhibiting_nitric_oxide_donator type Agent.
- COX-inhibiting_nitric_oxide_donator type Analgesic.
- COX-inhibiting_nitric_oxide_donator type Drug.
- COX-inhibiting_nitric_oxide_donator comment "COX-inhibiting nitric oxide donators (CINODs), also known as NO-NSAIDs, are a new class of non-steroidal anti-inflammatory drug (NSAID) developed with the intention of providing greater safety than existing NSAIDs.These compounds were first described by John Wallace and colleagues. CINODs are compounds generated by the fusion of an existing NSAID with a nitric oxide (NO)-donating moiety by chemical means, usually by ester linkage.".
- COX-inhibiting_nitric_oxide_donator label "COX-inhibiting nitric oxide donator".
- COX-inhibiting_nitric_oxide_donator sameAs COX-inhibiting_nitric_oxide_donator.
- COX-inhibiting_nitric_oxide_donator sameAs COX-inibitori_a_rilascio_di_monossido_di_azoto.
- COX-inhibiting_nitric_oxide_donator sameAs m.03h198m.
- COX-inhibiting_nitric_oxide_donator sameAs Q2931854.
- COX-inhibiting_nitric_oxide_donator sameAs Q2931854.
- COX-inhibiting_nitric_oxide_donator wasDerivedFrom COX-inhibiting_nitric_oxide_donator?oldid=621230351.
- COX-inhibiting_nitric_oxide_donator isPrimaryTopicOf COX-inhibiting_nitric_oxide_donator.