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- CLDN14 abstract "Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called claudins.The protein encoded by CLDN14 is an integral membrane protein and a component of tight junctions, one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets. Tight junctions form continuous seals around cells and serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space.These junctions are composed of sets of continuous networking protein strands in the outer surface of the cell membrane, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The CLDN14 protein also binds to particular part of a protein called Yes-associated protein, known as its WW domain.Defects in CLDN14 are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. Two transcript variants encoding the same protein have been found for this gene.There are also suggestions that CLDN14 plays a role in tumour angiogenesis (blood vessel formation), as deletion of a single copy of this gene leads to tight junction defects and leaky blood vessels in a mouse model.".
- CLDN14 entrezgene "23562".
- CLDN14 wikiPageExternalLink sticky-cells-blood-vessels-and-cancer-the-paradox-of-claudin-14.
- CLDN14 wikiPageID "14874099".
- CLDN14 wikiPageLength "7394".
- CLDN14 wikiPageOutDegree "11".
- CLDN14 wikiPageRevisionID "659857969".
- CLDN14 wikiPageWikiLink Alternative_splicing.
- CLDN14 wikiPageWikiLink Angiogenesis.
- CLDN14 wikiPageWikiLink Cell_adhesion.
- CLDN14 wikiPageWikiLink Claudin.
- CLDN14 wikiPageWikiLink Deafness.
- CLDN14 wikiPageWikiLink Endothelial.
- CLDN14 wikiPageWikiLink Endothelium.
- CLDN14 wikiPageWikiLink Epithelial.
- CLDN14 wikiPageWikiLink Epithelium.
- CLDN14 wikiPageWikiLink Gene.
- CLDN14 wikiPageWikiLink Hearing_loss.
- CLDN14 wikiPageWikiLink Model_organism.
- CLDN14 wikiPageWikiLink Mouse_model.
- CLDN14 wikiPageWikiLink Protein.
- CLDN14 wikiPageWikiLink Tight_junction.
- CLDN14 wikiPageWikiLink Tight_junctions.
- CLDN14 wikiPageWikiLink Transcript_variants.
- CLDN14 wikiPageWikiLinkText "CLDN14".
- CLDN14 hasPhotoCollection CLDN14.
- CLDN14 requireManualInspection "no".
- CLDN14 summaryText "The protein encoded by CLDN14 is an integral membrane protein and a component of tight junctions, one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets. Tight junctions form continuous seals around cells and serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking protein strands in the outer surface of the cell membrane, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The CLDN14 protein also binds to particular part of a protein called Yes-associated protein, known as its WW domain. Defects in CLDN14 are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. Two transcript variants encoding the same protein have been found for this gene.".
- CLDN14 updateCitations "yes".
- CLDN14 updatePage "yes".
- CLDN14 updateProteinBox "yes".
- CLDN14 updateSummary "yes".
- CLDN14 wikiPageUsesTemplate Template:Gene-21-stub.
- CLDN14 wikiPageUsesTemplate Template:PBB.
- CLDN14 wikiPageUsesTemplate Template:PBB_Controls.
- CLDN14 wikiPageUsesTemplate Template:PBB_Further_reading.
- CLDN14 wikiPageUsesTemplate Template:PBB_Summary.
- CLDN14 wikiPageUsesTemplate Template:Refbegin.
- CLDN14 wikiPageUsesTemplate Template:Refend.
- CLDN14 wikiPageUsesTemplate Template:Reflist.
- CLDN14 hypernym Protein.
- CLDN14 type Biomolecule.
- CLDN14 type Protein.
- CLDN14 type Thing.
- CLDN14 type Q206229.
- CLDN14 type Q8054.
- CLDN14 comment "Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called claudins.The protein encoded by CLDN14 is an integral membrane protein and a component of tight junctions, one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets.".
- CLDN14 label "CLDN14".
- CLDN14 sameAs m.03g_srh.
- CLDN14 sameAs Q5012698.
- CLDN14 sameAs Q5012698.
- CLDN14 wasDerivedFrom CLDN14?oldid=659857969.
- CLDN14 isPrimaryTopicOf CLDN14.