Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/CI-988> ?p ?o }
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- CI-988 abstract "CI-988 (PD-134,308) is a drug which acts as a cholecystokinin antagonist, selective for the CCKB subtype. In animal studies it showed anxiolytic effects and potentiated the analgesic action of both morphine and endogenous opioid peptides, as well as preventing the development of tolerance to opioids and reducing symptoms of withdrawal. Consequently it was hoped that it might have clinical applications for the treatment of pain and anxiety in humans, but trial results were disappointing with only minimal therapeutic effects observed even at high doses. The reason for the failure of CI-988 and other CCKB antagonists in humans despite their apparent promise in pre-clinical animal studies is unclear, although poor pharmacokinetic properties of the currently available drugs are a possible explanation, and CCKB antagonists are still being researched for possible uses as adjuvants to boost the activity of other drugs.".
- CI-988 casNumber "130332-27-3".
- CI-988 iupacName "4-([(1R)-2-([(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-([(tricyclo[3.3.1.13,7]dec-2-yloxy) carbonyl]amino)propyl]amino)-1-phenylethyl]amino)-4-oxobutanoic acid".
- CI-988 pubchem "108186".
- CI-988 thumbnail CI-988_structure.png?width=300.
- CI-988 wikiPageID "20490804".
- CI-988 wikiPageLength "6495".
- CI-988 wikiPageOutDegree "6".
- CI-988 wikiPageRevisionID "606754189".
- CI-988 wikiPageWikiLink Analgesic.
- CI-988 wikiPageWikiLink Anxiolytic.
- CI-988 wikiPageWikiLink Category:Cholecystokinin_antagonists.
- CI-988 wikiPageWikiLink Cholecystokinin_B_receptor.
- CI-988 wikiPageWikiLink Cholecystokinin_antagonist.
- CI-988 wikiPageWikiLink Morphine.
- CI-988 wikiPageWikiLinkText "CI-988".
- CI-988 c "35".
- CI-988 casNumber "130332".
- CI-988 chembl "2062154".
- CI-988 h "42".
- CI-988 hasPhotoCollection CI-988.
- CI-988 iupacName "4".
- CI-988 molecularWeight "614.73".
- CI-988 n "4".
- CI-988 o "6".
- CI-988 pubchem "108186".
- CI-988 verifiedrevid "432019597".
- CI-988 watchedfields "changed".
- CI-988 wikiPageUsesTemplate Template:Drugbox.
- CI-988 wikiPageUsesTemplate Template:Neuropeptide_agonists_and_antagonists.
- CI-988 wikiPageUsesTemplate Template:Reflist.
- CI-988 subject Category:Cholecystokinin_antagonists.
- CI-988 hypernym Drug.
- CI-988 type Article.
- CI-988 type ChemicalSubstance.
- CI-988 type Drug.
- CI-988 type Antagonist.
- CI-988 type Article.
- CI-988 type Chemical.
- CI-988 type ChemicalObject.
- CI-988 type Thing.
- CI-988 type Q8386.
- CI-988 comment "CI-988 (PD-134,308) is a drug which acts as a cholecystokinin antagonist, selective for the CCKB subtype. In animal studies it showed anxiolytic effects and potentiated the analgesic action of both morphine and endogenous opioid peptides, as well as preventing the development of tolerance to opioids and reducing symptoms of withdrawal.".
- CI-988 label "CI-988".
- CI-988 sameAs m.04zw8yk.
- CI-988 sameAs CI-988.
- CI-988 sameAs CI-988.
- CI-988 sameAs Q5011453.
- CI-988 sameAs Q5011453.
- CI-988 wasDerivedFrom CI-988?oldid=606754189.
- CI-988 depiction CI-988_structure.png.
- CI-988 isPrimaryTopicOf CI-988.