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- CHAP_domain abstract "In molecular biology, the CHAP domain is a region between 110 and 140 amino acids that is found in proteins from bacteria, bacteriophages, archaea and eukaryotes of the Trypanosomidae family. The domain is named after the acronym cysteine, histidine-dependent amidohydrolases/peptidases. Many of these proteins are uncharacterised, but it has been proposed that they may function mainly in peptidoglycan hydrolysis. The CHAP domain is found in a wide range of protein architectures; it is commonly associated with bacterial type SH3 domains and with several families of amidase domains. It has been suggested that CHAP domain containing proteins utilise a catalytic cysteine residue in a nucleophilic-attack mechanism.The CHAP domain contains two invariant residues, a cysteine and a histidine. These residues form part of the putative active site of CHAP domain containing proteins. Secondary structure predictions show that the CHAP domain belongs to the alpha + beta structural class, with the N-terminal half largely containing predicted alpha helices and the C-terminal half principally composed of predicted beta strands.Some proteins known to contain a CHAP domain are listed below: Bacterial and trypanosomal glutathionylspermidine amidases. A variety of bacterial autolysins. A Nocardia aerocolonigenes putative esterase. Streptococcus pneumoniae choline-binding protein D. Methanosarcina mazei protein MM2478, a putative chloride channel. Several phage-encoded peptidoglycan hydrolases. Cysteine peptidases belonging to MEROPS peptidase family C51 (D-alanyl-glycyl endopeptidase, clan CA).↑ 1.0 1.1 ↑ 2.0 2.1".
- CHAP_domain symbol "CHAP".
- CHAP_domain thumbnail PDB_2ioa_EBI.jpg?width=300.
- CHAP_domain wikiPageID "31685884".
- CHAP_domain wikiPageLength "3172".
- CHAP_domain wikiPageOutDegree "29".
- CHAP_domain wikiPageRevisionID "607771805".
- CHAP_domain wikiPageWikiLink Active_site.
- CHAP_domain wikiPageWikiLink Alpha_helix.
- CHAP_domain wikiPageWikiLink Amidase.
- CHAP_domain wikiPageWikiLink Archaea.
- CHAP_domain wikiPageWikiLink Bacteria.
- CHAP_domain wikiPageWikiLink Bacterial.
- CHAP_domain wikiPageWikiLink Beta_sheet.
- CHAP_domain wikiPageWikiLink Beta_strand.
- CHAP_domain wikiPageWikiLink Biomolecular_structure.
- CHAP_domain wikiPageWikiLink C-terminal.
- CHAP_domain wikiPageWikiLink C-terminus.
- CHAP_domain wikiPageWikiLink Catalysis.
- CHAP_domain wikiPageWikiLink Catalytic.
- CHAP_domain wikiPageWikiLink Category:Protein_domains.
- CHAP_domain wikiPageWikiLink Chloride.
- CHAP_domain wikiPageWikiLink Cysteine.
- CHAP_domain wikiPageWikiLink Eukaryote.
- CHAP_domain wikiPageWikiLink Eukaryotes.
- CHAP_domain wikiPageWikiLink Histidine.
- CHAP_domain wikiPageWikiLink MEROPS.
- CHAP_domain wikiPageWikiLink N-terminus.
- CHAP_domain wikiPageWikiLink Nuclear_receptor.
- CHAP_domain wikiPageWikiLink Peptidase.
- CHAP_domain wikiPageWikiLink Peptidoglycan.
- CHAP_domain wikiPageWikiLink Protease.
- CHAP_domain wikiPageWikiLink Protein.
- CHAP_domain wikiPageWikiLink Protein_domain.
- CHAP_domain wikiPageWikiLink Protein_family.
- CHAP_domain wikiPageWikiLink Proteins.
- CHAP_domain wikiPageWikiLink Region.
- CHAP_domain wikiPageWikiLink SH3_domain.
- CHAP_domain wikiPageWikiLink Secondary_structure.
- CHAP_domain wikiPageWikiLinkText "CHAP domain".
- CHAP_domain caption "E. coli Bifunctional glutathionylspermidine synthetase/amidase In complex with Mg2+ and ADP and phosphinate inhibitor.".
- CHAP_domain hasPhotoCollection CHAP_domain.
- CHAP_domain interpro "IPR007921".
- CHAP_domain merops "51.0".
- CHAP_domain name "CHAP".
- CHAP_domain pfam "PF05257".
- CHAP_domain pfamClan "CL0125".
- CHAP_domain symbol "CHAP".
- CHAP_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- CHAP_domain wikiPageUsesTemplate Template:InterPro_content.
- CHAP_domain wikiPageUsesTemplate Template:Reflist.
- CHAP_domain subject Category:Protein_domains.
- CHAP_domain hypernym Region.
- CHAP_domain type Biomolecule.
- CHAP_domain type Protein.
- CHAP_domain type Settlement.
- CHAP_domain type Chemical.
- CHAP_domain type Domain.
- CHAP_domain type Thing.
- CHAP_domain type Q206229.
- CHAP_domain type Q8054.
- CHAP_domain comment "In molecular biology, the CHAP domain is a region between 110 and 140 amino acids that is found in proteins from bacteria, bacteriophages, archaea and eukaryotes of the Trypanosomidae family. The domain is named after the acronym cysteine, histidine-dependent amidohydrolases/peptidases. Many of these proteins are uncharacterised, but it has been proposed that they may function mainly in peptidoglycan hydrolysis.".
- CHAP_domain label "CHAP domain".
- CHAP_domain sameAs m.0gmgmv_.
- CHAP_domain sameAs Q5011040.
- CHAP_domain sameAs Q5011040.
- CHAP_domain wasDerivedFrom CHAP_domain?oldid=607771805.
- CHAP_domain depiction PDB_2ioa_EBI.jpg.
- CHAP_domain isPrimaryTopicOf CHAP_domain.