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- CD25_deficiency abstract "CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The mutations cause expression of a defective α chain or complete absence thereof, an essential part of high-affinity interleukin-2 (IL-2) receptors. The result is a syndrome described as IPEX-like or a SCID.In one patient, deficiency of CD25 on CD4+ lymphocytes caused significantly impaired sensitivity to IL-2. This was demonstrated by a lack of measurable response in anti-inflammatory interleukin-10 (IL-10) secretion to low-dose IL-2 incubation. Greatly reduced IL-10 secretion compared to healthy humans results in a syndrome comparable to IPEX syndrome, a type of autoimmunity which is caused by FoxP3 transcription factor dysfunction. In addition to IPEX-like symptoms, CD25 deficiency increases susceptibility to viral infections and possibly fungal and bacterial infections.As IL-2 is an important inducer of lymphocyte proliferation, the absence of highly sensitive IL-2 receptors may also significantly hinder activation and clonal expansion of CD8+ and CD4+ lymphocytes and NK cells. One case also reported the absence of CD1, a MHC-like glycoprotein involved in the presentation of lipid antigens to T cells, in a CD25 deficient patient. Furthermore, chronic upregulation of anti-apoptotic Bcl-2 in thymocytes was also described possibly allowing autoreactive T cells to escape deletion.".
- CD25_deficiency omim "606367".
- CD25_deficiency wikiPageID "34244700".
- CD25_deficiency wikiPageLength "3156".
- CD25_deficiency wikiPageOutDegree "22".
- CD25_deficiency wikiPageRevisionID "596629275".
- CD25_deficiency wikiPageWikiLink Antigen.
- CD25_deficiency wikiPageWikiLink Antigens.
- CD25_deficiency wikiPageWikiLink Apoptosis.
- CD25_deficiency wikiPageWikiLink Bcl-2.
- CD25_deficiency wikiPageWikiLink CD1.
- CD25_deficiency wikiPageWikiLink CD4+_lymphocytes.
- CD25_deficiency wikiPageWikiLink CD8+_lymphocyte.
- CD25_deficiency wikiPageWikiLink Category:Genetic_disorders_by_system.
- CD25_deficiency wikiPageWikiLink Category:Noninfectious_immunodeficiency-related_cutaneous_conditions.
- CD25_deficiency wikiPageWikiLink Cell_growth.
- CD25_deficiency wikiPageWikiLink Cell_proliferation.
- CD25_deficiency wikiPageWikiLink Clonal_expansion.
- CD25_deficiency wikiPageWikiLink FOXP3.
- CD25_deficiency wikiPageWikiLink FoxP3.
- CD25_deficiency wikiPageWikiLink Gene_expression.
- CD25_deficiency wikiPageWikiLink IL-2_receptor.
- CD25_deficiency wikiPageWikiLink IPEX_(syndrome).
- CD25_deficiency wikiPageWikiLink IPEX_syndrome.
- CD25_deficiency wikiPageWikiLink Interleukin-10.
- CD25_deficiency wikiPageWikiLink Interleukin-2.
- CD25_deficiency wikiPageWikiLink Interleukin_10.
- CD25_deficiency wikiPageWikiLink Interleukin_2.
- CD25_deficiency wikiPageWikiLink Lipid.
- CD25_deficiency wikiPageWikiLink Lymphocyte.
- CD25_deficiency wikiPageWikiLink Major_histocompatibility_complex.
- CD25_deficiency wikiPageWikiLink NK_cells.
- CD25_deficiency wikiPageWikiLink Natural_killer_cell.
- CD25_deficiency wikiPageWikiLink Severe_combined_immunodeficiency.
- CD25_deficiency wikiPageWikiLink T_helper_cell.
- CD25_deficiency wikiPageWikiLink Thymocyte.
- CD25_deficiency wikiPageWikiLink Thymocytes.
- CD25_deficiency wikiPageWikiLinkText "CD25 deficiency".
- CD25_deficiency hasPhotoCollection CD25_deficiency.
- CD25_deficiency name "CD25 deficiency".
- CD25_deficiency omim "606367".
- CD25_deficiency wikiPageUsesTemplate Template:Immune_disorders.
- CD25_deficiency wikiPageUsesTemplate Template:Infobox_disease.
- CD25_deficiency wikiPageUsesTemplate Template:Reflist.
- CD25_deficiency subject Category:Genetic_disorders_by_system.
- CD25_deficiency subject Category:Noninfectious_immunodeficiency-related_cutaneous_conditions.
- CD25_deficiency hypernym Disorder.
- CD25_deficiency type Disease.
- CD25_deficiency type Disorder.
- CD25_deficiency type Thing.
- CD25_deficiency type Q12136.
- CD25_deficiency comment "CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The mutations cause expression of a defective α chain or complete absence thereof, an essential part of high-affinity interleukin-2 (IL-2) receptors. The result is a syndrome described as IPEX-like or a SCID.In one patient, deficiency of CD25 on CD4+ lymphocytes caused significantly impaired sensitivity to IL-2.".
- CD25_deficiency label "CD25 deficiency".
- CD25_deficiency sameAs m.0hzqljk.
- CD25_deficiency sameAs Q5009803.
- CD25_deficiency sameAs Q5009803.
- CD25_deficiency wasDerivedFrom CD25_deficiency?oldid=596629275.
- CD25_deficiency isPrimaryTopicOf CD25_deficiency.
- CD25_deficiency name "CD25 deficiency".