Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/CBFB> ?p ?o }
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- CBFB abstract "Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene.The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. Mutations in CBFB are implicated in cases of breast cancer.Core binding factor acute myeloid leukaemia is a cancer related to genetic changes in the CBF gene. It is most commonly caused by an inversion of particular region of chromosome 16; however it can also be caused by translocation between copies of chromosome 16. The rearrangements cause formation of CBF but with impaired function. This prevents proper differentiation of blood cells, leading to the formation of Myeloblast.".
- CBFB entrezgene "865".
- CBFB wikiPageID "14181500".
- CBFB wikiPageLength "9097".
- CBFB wikiPageOutDegree "9".
- CBFB wikiPageRevisionID "683011864".
- CBFB wikiPageWikiLink Breast_cancer.
- CBFB wikiPageWikiLink Gene.
- CBFB wikiPageWikiLink Haematopoiesis.
- CBFB wikiPageWikiLink Hematopoiesis.
- CBFB wikiPageWikiLink MYH11.
- CBFB wikiPageWikiLink Myeloblast.
- CBFB wikiPageWikiLink Protein.
- CBFB wikiPageWikiLink RUNX1.
- CBFB wikiPageWikiLink RUNX2.
- CBFB wikiPageWikiLink Transcription_factor.
- CBFB wikiPageWikiLinkText "CBFB".
- CBFB wikiPageWikiLinkText "CBFβ".
- CBFB hasPhotoCollection CBFB.
- CBFB requireManualInspection "no".
- CBFB summaryText "The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis and osteogenesis . The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.".
- CBFB updateCitations "yes".
- CBFB updatePage "yes".
- CBFB updateProteinBox "yes".
- CBFB updateSummary "yes".
- CBFB wikiPageUsesTemplate Template:Gene-16-stub.
- CBFB wikiPageUsesTemplate Template:PBB.
- CBFB wikiPageUsesTemplate Template:PBB_Controls.
- CBFB wikiPageUsesTemplate Template:PBB_Further_reading.
- CBFB wikiPageUsesTemplate Template:PBB_Summary.
- CBFB wikiPageUsesTemplate Template:PDB_Gallery.
- CBFB wikiPageUsesTemplate Template:Refbegin.
- CBFB wikiPageUsesTemplate Template:Refend.
- CBFB wikiPageUsesTemplate Template:Reflist.
- CBFB hypernym Protein.
- CBFB type Biomolecule.
- CBFB type Protein.
- CBFB type Thing.
- CBFB type Q206229.
- CBFB type Q8054.
- CBFB comment "Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene.The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2).".
- CBFB label "CBFB".
- CBFB sameAs m.03cx2z7.
- CBFB sameAs Q5009085.
- CBFB sameAs Q5009085.
- CBFB wasDerivedFrom CBFB?oldid=683011864.
- CBFB isPrimaryTopicOf CBFB.