Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/CAS/CSE_protein_family> ?p ?o }
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- CSE_protein_family abstract "In molecular biology, the CAS/CSE protein family is a family of proteins which includes mammalian cellular apoptosis susceptibility (CAS) proteins and yeast chromosome-segregation protein, CSE1. CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle, as is the protein MEK, which is thought to regulate the intracellular localization (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins.The CAS/CSE family of proteins consist of two domains. An N-terminal Cse1 domain, which contains HEAT repeats, and a C-terminal domain.".
- CSE_protein_family symbol "CAS_CSE1".
- CSE_protein_family symbol "Cse1".
- CSE_protein_family thumbnail PDB_1z3h_EBI.jpg?width=300.
- CSE_protein_family wikiPageID "32190659".
- CSE_protein_family wikiPageLength "5452".
- CSE_protein_family wikiPageOutDegree "26".
- CSE_protein_family wikiPageRevisionID "678224090".
- CSE_protein_family wikiPageWikiLink Apoptosis.
- CSE_protein_family wikiPageWikiLink Category:Protein_families.
- CSE_protein_family wikiPageWikiLink Cell_(biology).
- CSE_protein_family wikiPageWikiLink Cell_cycle.
- CSE_protein_family wikiPageWikiLink Cell_cycle_checkpoint.
- CSE_protein_family wikiPageWikiLink Cell_growth.
- CSE_protein_family wikiPageWikiLink Cell_nucleus.
- CSE_protein_family wikiPageWikiLink Cell_reproduction.
- CSE_protein_family wikiPageWikiLink Cytosol.
- CSE_protein_family wikiPageWikiLink Cytosolic.
- CSE_protein_family wikiPageWikiLink G2_phase.
- CSE_protein_family wikiPageWikiLink Gene_expression.
- CSE_protein_family wikiPageWikiLink Importin.
- CSE_protein_family wikiPageWikiLink Mammal.
- CSE_protein_family wikiPageWikiLink Mammalian.
- CSE_protein_family wikiPageWikiLink Microtubule.
- CSE_protein_family wikiPageWikiLink Mitosis.
- CSE_protein_family wikiPageWikiLink Mitotic.
- CSE_protein_family wikiPageWikiLink Mitotic_spindle.
- CSE_protein_family wikiPageWikiLink Nuclear_transport.
- CSE_protein_family wikiPageWikiLink P53.
- CSE_protein_family wikiPageWikiLink Protein.
- CSE_protein_family wikiPageWikiLink Protein_domain.
- CSE_protein_family wikiPageWikiLink Protein_domains.
- CSE_protein_family wikiPageWikiLink Proteins.
- CSE_protein_family wikiPageWikiLink Saccharomyces_cerevisiae.
- CSE_protein_family wikiPageWikiLink Spindle_apparatus.
- CSE_protein_family wikiPageWikiLink Transcription_(genetics).
- CSE_protein_family wikiPageWikiLink Transcriptional_regulation.
- CSE_protein_family wikiPageWikiLink Transport.
- CSE_protein_family wikiPageWikiLinkText "CAS (cellular apoptosis susceptibility protein)".
- CSE_protein_family wikiPageWikiLinkText "CAS protein family".
- CSE_protein_family wikiPageWikiLinkText "CAS".
- CSE_protein_family wikiPageWikiLinkText "Cas family".
- CSE_protein_family caption "the exportin cse1 in its cargo-free, cytoplasmic state".
- CSE_protein_family hasPhotoCollection CSE_protein_family.
- CSE_protein_family interpro "IPR005043".
- CSE_protein_family interpro "IPR013713".
- CSE_protein_family name "CAS/CSE protein, C-terminus".
- CSE_protein_family name "Cse1".
- CSE_protein_family pfam "PF03378".
- CSE_protein_family pfam "PF08506".
- CSE_protein_family pfamClan "CL0020".
- CSE_protein_family symbol "CAS_CSE1".
- CSE_protein_family symbol "Cse1".
- CSE_protein_family wikiPageUsesTemplate Template:Infobox_protein_family.
- CSE_protein_family wikiPageUsesTemplate Template:InterPro_content.
- CSE_protein_family wikiPageUsesTemplate Template:Reflist.
- CSE_protein_family subject Category:Protein_families.
- CSE_protein_family hypernym Family.
- CSE_protein_family type Article.
- CSE_protein_family type Biomolecule.
- CSE_protein_family type Protein.
- CSE_protein_family type Article.
- CSE_protein_family type Chemical.
- CSE_protein_family type Thing.
- CSE_protein_family type Q206229.
- CSE_protein_family type Q8054.
- CSE_protein_family comment "In molecular biology, the CAS/CSE protein family is a family of proteins which includes mammalian cellular apoptosis susceptibility (CAS) proteins and yeast chromosome-segregation protein, CSE1. CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation.".
- CSE_protein_family label "CAS/CSE protein family".
- CSE_protein_family sameAs m.0gxzry4.
- CSE_protein_family sameAs Q5008842.
- CSE_protein_family sameAs Q5008842.
- CSE_protein_family wasDerivedFrom CSE_protein_family?oldid=678224090.
- CSE_protein_family depiction PDB_1z3h_EBI.jpg.
- CSE_protein_family isPrimaryTopicOf CSE_protein_family.
