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- C3-convertase abstract "C3 convertase (EC 3.4.21.43, Classical-complement-pathway C3/C5 convertase, C overbar 42 , C4b,2a, C5 convertase, C overbar 423, C4b,2a,3b, C42, C5 convertase, C423, C4b,2a,3b, complement C.hivin.4.hivin2, complement C3 convertase) belongs to family of serine proteases and is necessary in innate immunity as a part of complement system which eventuate in opsonisation of particles, release of inflammatory peptides, C5 convertase formation and cell lysis. C3 convertase exists in two forms (C3bBb and C4bC2a) but both of them cleave only C3, central molecule of complement system.Complement system can be activated in three different pathways – classical, lectin and alternative pathway. All of these activation pathways lead to enzymatic cleavage of C3. Newly created fragments C3a and C3b are important in next steps of complement cascade development. The smaller fragment called C3a is released and stimulates inflammation through the chemoattractant activity. C3b, the larger fragment, becomes covalently attached to the microbial surface or to the antibody molecules through the thioester domain at the site of complement activation. After cleavage and binding to cell surface, the C3b fragment is ready to bind a plasma protein called Factor B. The Factor B (a zymogen) is cleaved by a plasma serine protease Factor D releasing a small fragment called Ba and generating a larger fragment called Bb that remains attached to C3b. Also Mg2+ ions are necessary for forming a functional C3 convertase. Thus, the alternative pathway C3 convertase is formed and is able to cleave C3 now.Another form, the classical pathway C3 convertase contains different proteins of complement system – C4b and C2a. These fragments form during the classical or lectin pathway of the complement. The cleavage of C4 and C2 is mediated by serine proteases - C1 complex (C1q, C1r, C1s) in classical pathway and Mannose-binding lectin-associated serine proteases (MASPs: MASP1, MASP2, MASP3) in lectin pathway. C4 is homologous to C3, and C4b contains an internal thioester bond, similar to that in C3b, that forms covalent amide or ester linkages with the antigen-antibody complex or with the adjacent surface of a cell to which is antibody bound. C2 is cleaved by C1s to a smaller fragment called C2b and larger fragment called C2a that binds to C4b. The fragments C4a and C2b are released.Once formed, both C3 convertases will catalyze the proteolytic cleavage of C3 into C3a and C3b (hence the name "C3-convertase"). C3b can then act as an opsonin or bind to activated bimolecular complex C4b2a to form a trimolecular complex, C5 convertase, which is a specific enzyme for C5.".
- C3-convertase ecNumber "3.4.21.43".
- C3-convertase thumbnail Complement_pathway.png?width=300.
- C3-convertase wikiPageID "1148012".
- C3-convertase wikiPageLength "9620".
- C3-convertase wikiPageOutDegree "40".
- C3-convertase wikiPageRevisionID "681960067".
- C3-convertase wikiPageWikiLink Alternative_complement_pathway.
- C3-convertase wikiPageWikiLink Antibody.
- C3-convertase wikiPageWikiLink Antigen.
- C3-convertase wikiPageWikiLink C2a.
- C3-convertase wikiPageWikiLink C3_(complement).
- C3-convertase wikiPageWikiLink C3a_(complement).
- C3-convertase wikiPageWikiLink C3b.
- C3-convertase wikiPageWikiLink C4b.
- C3-convertase wikiPageWikiLink C4b-binding_protein.
- C3-convertase wikiPageWikiLink C5-convertase.
- C3-convertase wikiPageWikiLink C5_convertase.
- C3-convertase wikiPageWikiLink CD46.
- C3-convertase wikiPageWikiLink Category:Complement_system.
- C3-convertase wikiPageWikiLink Category:EC_3.4.21.
- C3-convertase wikiPageWikiLink Chemoattractant.
- C3-convertase wikiPageWikiLink Chemotaxis.
- C3-convertase wikiPageWikiLink Classical_complement_pathway.
- C3-convertase wikiPageWikiLink Complement_(biology).
- C3-convertase wikiPageWikiLink Complement_component_2.
- C3-convertase wikiPageWikiLink Complement_component_3.
- C3-convertase wikiPageWikiLink Complement_component_4.
- C3-convertase wikiPageWikiLink Complement_component_5.
- C3-convertase wikiPageWikiLink Complement_control_protein.
- C3-convertase wikiPageWikiLink Complement_factor_B.
- C3-convertase wikiPageWikiLink Complement_factor_I.
- C3-convertase wikiPageWikiLink Complement_receptor.
- C3-convertase wikiPageWikiLink Complement_system.
- C3-convertase wikiPageWikiLink Decay_acceleration_factor.
- C3-convertase wikiPageWikiLink Factor_D.
- C3-convertase wikiPageWikiLink Factor_H.
- C3-convertase wikiPageWikiLink Inflammation.
- C3-convertase wikiPageWikiLink Inflammatory_peptide.
- C3-convertase wikiPageWikiLink Innate_immune_system.
- C3-convertase wikiPageWikiLink Innate_immunity.
- C3-convertase wikiPageWikiLink Lectin_pathway.
- C3-convertase wikiPageWikiLink Mannan-binding_lectin.
- C3-convertase wikiPageWikiLink Mannan-binding_lectin_pathway.
- C3-convertase wikiPageWikiLink Membrane_cofactor_protein.
- C3-convertase wikiPageWikiLink Opsonin.
- C3-convertase wikiPageWikiLink Opsonisation.
- C3-convertase wikiPageWikiLink Properdin.
- C3-convertase wikiPageWikiLink Regulators_of_complement_activation.
- C3-convertase wikiPageWikiLink Serine_protease.
- C3-convertase wikiPageWikiLink Thioester.
- C3-convertase wikiPageWikiLink Zymogen.
- C3-convertase wikiPageWikiLink File:Complement-pathways.png.
- C3-convertase wikiPageWikiLink File:Complement_pathway.png.
- C3-convertase wikiPageWikiLinkText "C3-convertase".
- C3-convertase casNumber "56626".
- C3-convertase ecNumber "3.4".
- C3-convertase hasPhotoCollection C3-convertase.
- C3-convertase iubmbEcNumber "3".
- C3-convertase name "Classical-complement-pathway C3/C5 convertase".
- C3-convertase wikiPageUsesTemplate Template:Complement_system.
- C3-convertase wikiPageUsesTemplate Template:EC_number.
- C3-convertase wikiPageUsesTemplate Template:Infobox_enzyme.
- C3-convertase wikiPageUsesTemplate Template:MeshName.
- C3-convertase wikiPageUsesTemplate Template:Reflist.
- C3-convertase wikiPageUsesTemplate Template:Serine_endopeptidases.
- C3-convertase subject Category:Complement_system.
- C3-convertase subject Category:EC_3.4.21.
- C3-convertase type Biomolecule.
- C3-convertase type Enzyme.
- C3-convertase type Thing.
- C3-convertase type Q206229.
- C3-convertase type Q8047.
- C3-convertase comment "C3 convertase (EC 3.4.21.43, Classical-complement-pathway C3/C5 convertase, C overbar 42 , C4b,2a, C5 convertase, C overbar 423, C4b,2a,3b, C42, C5 convertase, C423, C4b,2a,3b, complement C.hivin.4.hivin2, complement C3 convertase) belongs to family of serine proteases and is necessary in innate immunity as a part of complement system which eventuate in opsonisation of particles, release of inflammatory peptides, C5 convertase formation and cell lysis.".
- C3-convertase label "C3-convertase".
- C3-convertase sameAs C3_konvertáza.
- C3-convertase sameAs Convertase_de_C3.
- C3-convertase sameAs Konwertaza_C3.
- C3-convertase sameAs m.04bf3h.
- C3-convertase sameAs C5_konvertaza.
- C3-convertase sameAs C5_konvertaza.
- C3-convertase sameAs Q5008114.
- C3-convertase sameAs Q5008114.
- C3-convertase wasDerivedFrom C3-convertase?oldid=681960067.
- C3-convertase depiction Complement_pathway.png.
- C3-convertase isPrimaryTopicOf C3-convertase.
- C3-convertase name "Classical-complement-pathway C3/C5 convertase".