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- Bromodeoxyuridine abstract "Bromodeoxyuridine (5-bromo-2'-deoxyuridine, BrdU, BUdR, BrdUrd) is a synthetic nucleoside that is an analog of thymidine. BrdU is commonly used in the detection of proliferating cells in living tissues. 5-Bromodeoxycytidine is deaminated to form BrdU.BrdU can be incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle during which DNA is replicated), substituting for thymidine during DNA replication. Antibodies specific for BrdU can then be used to detect the incorporated chemical (see immunohistochemistry), thus indicating cells that were actively replicating their DNA. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat.BrdU can be passed to daughter cells upon replication. BrdU has been demonstrated to be detectable over two years post-infusion.Because BrdU can replace thymidine during DNA replication, it can cause mutations, and its use is therefore potentially a health hazard. However, because it is neither radioactive nor myelotoxic at labeling concentrations, it is widely preferred for in vivo studies of cancer cell proliferation. However, at radiosensitizing concentrations, BrdU becomes myelosuppressive thus limiting its use for radiosensitizing.BrdU differs from thymidine in that BrdU substitutes a bromine atom for thymidine's CH3 group. The Br substitution can be used in X-Ray diffraction experiments in crystals containing either DNA or RNA. The Br atom acts as an anomalous scatterer and its larger size will affect the crystal's x-ray diffraction enough to detect isomorphous differences as well.Bromodeoxyuridine releases gene silencing caused by DNA methylation.BrdU can also be also used to identify microorganisms that respond to specific carbon substrates in aquatic and soil environments. A carbon substrate added to incubations of environmental samples will cause the growth of microorganisms that can utilize that substrate. These microorganisms will then incorporate BrdU into their DNA as they grow. Community DNA can then be isolated and BrdU-labeled DNA purified using an immunocapture technique. Subsequent sequencing of the labeled DNA can then be used to identify the microbial taxa that participated in the degradation of the added carbon source.However, it is not certain whether all microbes present in an environmental sample can incorporate BrdU into their biomass during de novo DNA synthesis. Therefore, a group of microorganisms may respond to a C source but go undetected using this technique. Additionally, this technique is biased towards identifying microorganisms with A and T rich genomes.".
- Bromodeoxyuridine thumbnail Bromodeoxyuridine.svg?width=300.
- Bromodeoxyuridine wikiPageExternalLink Bromodeoxyuridine_%28BrdU%29.
- Bromodeoxyuridine wikiPageExternalLink Modifications.aspx?ProductID=1390.
- Bromodeoxyuridine wikiPageID "5381677".
- Bromodeoxyuridine wikiPageLength "9779".
- Bromodeoxyuridine wikiPageOutDegree "26".
- Bromodeoxyuridine wikiPageRevisionID "675962361".
- Bromodeoxyuridine wikiPageWikiLink 5-Bromouracil.
- Bromodeoxyuridine wikiPageWikiLink 5-Ethynyl-2-deoxyuridine.
- Bromodeoxyuridine wikiPageWikiLink Antibody.
- Bromodeoxyuridine wikiPageWikiLink Bone_marrow_suppression.
- Bromodeoxyuridine wikiPageWikiLink Bromine.
- Bromodeoxyuridine wikiPageWikiLink Cancer.
- Bromodeoxyuridine wikiPageWikiLink Category:Nucleosides.
- Bromodeoxyuridine wikiPageWikiLink Category:Organobromides.
- Bromodeoxyuridine wikiPageWikiLink Category:Pyrimidinediones.
- Bromodeoxyuridine wikiPageWikiLink Category:Staining_dyes.
- Bromodeoxyuridine wikiPageWikiLink Cell_cycle.
- Bromodeoxyuridine wikiPageWikiLink DNA.
- Bromodeoxyuridine wikiPageWikiLink DNA_replication.
- Bromodeoxyuridine wikiPageWikiLink Denaturation_(biochemistry).
- Bromodeoxyuridine wikiPageWikiLink Immunohistochemistry.
- Bromodeoxyuridine wikiPageWikiLink Mutation.
- Bromodeoxyuridine wikiPageWikiLink Myelotoxic.
- Bromodeoxyuridine wikiPageWikiLink Nucleoside.
- Bromodeoxyuridine wikiPageWikiLink Radioactive.
- Bromodeoxyuridine wikiPageWikiLink Radioactive_decay.
- Bromodeoxyuridine wikiPageWikiLink Radiosensitizer.
- Bromodeoxyuridine wikiPageWikiLink Radiosensitizing.
- Bromodeoxyuridine wikiPageWikiLink S_phase.
- Bromodeoxyuridine wikiPageWikiLink Structural_analog.
- Bromodeoxyuridine wikiPageWikiLink Thymidine.
- Bromodeoxyuridine wikiPageWikiLinkText "BrdU".
- Bromodeoxyuridine wikiPageWikiLinkText "Bromodeoxyuridine (BrdU)".
- Bromodeoxyuridine wikiPageWikiLinkText "Bromodeoxyuridine".
- Bromodeoxyuridine wikiPageWikiLinkText "bromodeoxyuridine".
- Bromodeoxyuridine hasPhotoCollection Bromodeoxyuridine.
- Bromodeoxyuridine imagefile "Bromodeoxyuridine.svg".
- Bromodeoxyuridine verifiedfields "changed".
- Bromodeoxyuridine verifiedrevid "401935585".
- Bromodeoxyuridine watchedfields "changed".
- Bromodeoxyuridine wikiPageUsesTemplate Template:Chembox.
- Bromodeoxyuridine wikiPageUsesTemplate Template:Clarify.
- Bromodeoxyuridine wikiPageUsesTemplate Template:Reflist.
- Bromodeoxyuridine subject Category:Nucleosides.
- Bromodeoxyuridine subject Category:Organobromides.
- Bromodeoxyuridine subject Category:Pyrimidinediones.
- Bromodeoxyuridine subject Category:Staining_dyes.
- Bromodeoxyuridine hypernym Nucleoside.
- Bromodeoxyuridine type Article.
- Bromodeoxyuridine type ChemicalCompound.
- Bromodeoxyuridine type ChemicalSubstance.
- Bromodeoxyuridine type Article.
- Bromodeoxyuridine type Chemical.
- Bromodeoxyuridine type Glycoside.
- Bromodeoxyuridine type Heterocycle.
- Bromodeoxyuridine type Lactam.
- Bromodeoxyuridine type Nucleoside.
- Bromodeoxyuridine type Organohalide.
- Bromodeoxyuridine type Organohalide.
- Bromodeoxyuridine type ChemicalObject.
- Bromodeoxyuridine type Thing.
- Bromodeoxyuridine type Q11173.
- Bromodeoxyuridine comment "Bromodeoxyuridine (5-bromo-2'-deoxyuridine, BrdU, BUdR, BrdUrd) is a synthetic nucleoside that is an analog of thymidine. BrdU is commonly used in the detection of proliferating cells in living tissues. 5-Bromodeoxycytidine is deaminated to form BrdU.BrdU can be incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle during which DNA is replicated), substituting for thymidine during DNA replication.".
- Bromodeoxyuridine label "Bromodeoxyuridine".
- Bromodeoxyuridine sameAs Bromdesoxyuridin.
- Bromodeoxyuridine sameAs برموداکسیاوریدین.
- Bromodeoxyuridine sameAs Bromodésoxyuridine.
- Bromodeoxyuridine sameAs m.0djb49.
- Bromodeoxyuridine sameAs Бромдезоксиуридин.
- Bromodeoxyuridine sameAs Bromodeoksiuridin.
- Bromodeoxyuridine sameAs Bromodeoksiuridin.
- Bromodeoxyuridine sameAs Bromdeoxiuridin.
- Bromodeoxyuridine sameAs Q419861.
- Bromodeoxyuridine sameAs Q419861.
- Bromodeoxyuridine sameAs 溴化去氧尿苷.
- Bromodeoxyuridine wasDerivedFrom Bromodeoxyuridine?oldid=675962361.
- Bromodeoxyuridine depiction Bromodeoxyuridine.svg.
- Bromodeoxyuridine isPrimaryTopicOf Bromodeoxyuridine.