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- Brincidofovir abstract "Brincidofovir (CMX001) is an experimental antiviral drug being developed by Chimerix of Durham, NC, for the treatment of cytomegalovirus, adenovirus, smallpox, and ebolavirus infections. Brincidofovir is a prodrug of cidofovir. Conjugated to a lipid, the compound is designed to release cidofovir intracellularly, allowing for higher intracellular and lower plasma concentrations of cidofovir, effectively increasing its activity against dsDNA viruses, as well as oral bioavailability.In animal trials the drug has shown activity against cytomegalovirus, adenoviruses, BK virus, smallpox, and herpes simplex viruses. Preliminary in vitro tests have also shown it to have potential for the treatment of Ebola virus disease, which is somewhat paradoxical, as Ebola is not a DNA virus.Brincidofovir is currently in Phase III clinical trials for use in humans against cytomegalovirus and adenovirus, after testing for safety in over 1000 human subjects, and has received FDA Fast Track Designation for treatment of cytomegalovirus, adenovirus, and smallpox. On October 6, 2014, Chimerix received an FDA authorization for emergency investigational new drug applications of brincidofovir for the treatment of Ebola virus disease.Brincidofovir was administered to the first patient diagnosed in the Ebola virus disease outbreak in the US in 2014. The patient was given the drug starting six days after hospital admission when he was already critically ill; he died four days later. Brincidofovir was also given to Ebola patient Ashoka Mukpo at the Nebraska Medical Center, who had developed the disease and then was pronounced Ebola-free and released from the Center on 22 October 2014.In October 2014, Chimerix reported it had been given approval by the FDA to start Phase 2 trials in patients infected with ebolaviruses for brincidofovir's safety, tolerability, and efficacy. A trial commenced during January 2015 in Liberia, but was subsequently discontinued. Because of a lack of suitable subjects in Liberia, Oxford University and Médecins Sans Frontières planned to extend the trial to Sierra Leone, where there were still Ebola cases; but on the 30th of January 2015, the manufacturer decided to withdraw support for the trial and end discussion of future trials.".
- Brincidofovir thumbnail Brincidofovir.svg?width=300.
- Brincidofovir wikiPageID "42176118".
- Brincidofovir wikiPageLength "10031".
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- Brincidofovir wikiPageRevisionID "657303967".
- Brincidofovir wikiPageWikiLink 2014_United_States_Ebola_virus_outbreak.
- Brincidofovir wikiPageWikiLink Adenoviridae.
- Brincidofovir wikiPageWikiLink Adenovirus.
- Brincidofovir wikiPageWikiLink Antiviral_drug.
- Brincidofovir wikiPageWikiLink BCX4430.
- Brincidofovir wikiPageWikiLink BK_virus.
- Brincidofovir wikiPageWikiLink Category:Antivirals.
- Brincidofovir wikiPageWikiLink Category:Ebola.
- Brincidofovir wikiPageWikiLink Category:Phosphonate_esters.
- Brincidofovir wikiPageWikiLink Category:Prodrugs.
- Brincidofovir wikiPageWikiLink Category:Pyrimidones.
- Brincidofovir wikiPageWikiLink Chimerix.
- Brincidofovir wikiPageWikiLink Cidofovir.
- Brincidofovir wikiPageWikiLink Compassionate_use.
- Brincidofovir wikiPageWikiLink Cytomegalovirus.
- Brincidofovir wikiPageWikiLink DNA_virus.
- Brincidofovir wikiPageWikiLink Drug_development.
- Brincidofovir wikiPageWikiLink DsDNA_virus.
- Brincidofovir wikiPageWikiLink Durham,_NC.
- Brincidofovir wikiPageWikiLink Durham,_North_Carolina.
- Brincidofovir wikiPageWikiLink Ebola_virus_cases_in_the_United_States.
- Brincidofovir wikiPageWikiLink Ebola_virus_disease.
- Brincidofovir wikiPageWikiLink Ebolavirus.
- Brincidofovir wikiPageWikiLink Expanded_access.
- Brincidofovir wikiPageWikiLink FDA.
- Brincidofovir wikiPageWikiLink FDA_Fast_Track_Development_Program.
- Brincidofovir wikiPageWikiLink FGI-106.
- Brincidofovir wikiPageWikiLink Favipiravir.
- Brincidofovir wikiPageWikiLink Food_and_Drug_Administration.
- Brincidofovir wikiPageWikiLink Herpes_simplex_virus.
- Brincidofovir wikiPageWikiLink Intracellular.
- Brincidofovir wikiPageWikiLink JK-05.
- Brincidofovir wikiPageWikiLink Lamivudine.
- Brincidofovir wikiPageWikiLink Lipid.
- Brincidofovir wikiPageWikiLink Médecins_Sans_Frontières.
- Brincidofovir wikiPageWikiLink Oxford_University.
- Brincidofovir wikiPageWikiLink Phase_III_clinical_trial.
- Brincidofovir wikiPageWikiLink Phases_of_clinical_research.
- Brincidofovir wikiPageWikiLink Prodrug.
- Brincidofovir wikiPageWikiLink Sierra_Leone.
- Brincidofovir wikiPageWikiLink Smallpox.
- Brincidofovir wikiPageWikiLink Social_media.
- Brincidofovir wikiPageWikiLink Social_media_campaign.
- Brincidofovir wikiPageWikiLink TKM-Ebola.
- Brincidofovir wikiPageWikiLink University_of_Oxford.
- Brincidofovir wikiPageWikiLink ZMapp.
- Brincidofovir wikiPageWikiLinkText "Brincidofovir".
- Brincidofovir c "27".
- Brincidofovir casNumber "444805".
- Brincidofovir chembl "203321".
- Brincidofovir chemspiderid "424003".
- Brincidofovir drugName "Brincidofovir".
- Brincidofovir h "52".
- Brincidofovir hasPhotoCollection Brincidofovir.
- Brincidofovir inchi "1".
- Brincidofovir inchikey "WXJFKKQWPMNTIM-VWLOTQADBY".
- Brincidofovir legalUs "Investigational".
- Brincidofovir molecularWeight "561.7".
- Brincidofovir n "3".
- Brincidofovir o "7".
- Brincidofovir p "1".
- Brincidofovir pubchem "483477".
- Brincidofovir smiles "CCCCCCCCCCCCCCCCOCCCOPO".
- Brincidofovir stdinchi "1".
- Brincidofovir stdinchikey "WXJFKKQWPMNTIM-VWLOTQADSA-N".
- Brincidofovir synonyms "CMX001; Cidofovir-HDP; hexadecyloxypropyl-cidofovir".
- Brincidofovir wikiPageUsesTemplate Template:Ebola.
- Brincidofovir wikiPageUsesTemplate Template:Infobox_drug.
- Brincidofovir wikiPageUsesTemplate Template:Reflist.
- Brincidofovir subject Category:Antivirals.
- Brincidofovir subject Category:Ebola.
- Brincidofovir subject Category:Phosphonate_esters.
- Brincidofovir subject Category:Prodrugs.
- Brincidofovir subject Category:Pyrimidones.
- Brincidofovir hypernym Drug.
- Brincidofovir type ChemicalSubstance.
- Brincidofovir type Drug.
- Brincidofovir type ChemicalObject.
- Brincidofovir type Thing.
- Brincidofovir type Q8386.
- Brincidofovir comment "Brincidofovir (CMX001) is an experimental antiviral drug being developed by Chimerix of Durham, NC, for the treatment of cytomegalovirus, adenovirus, smallpox, and ebolavirus infections. Brincidofovir is a prodrug of cidofovir.".
- Brincidofovir label "Brincidofovir".
- Brincidofovir sameAs Brincidofovir.
- Brincidofovir sameAs Brincidofovir.
- Brincidofovir sameAs Brintsidofoviir.
- Brincidofovir sameAs Brincidofovir.
- Brincidofovir sameAs m.0_yjpy9.
- Brincidofovir sameAs Бринцидофовір.
- Brincidofovir sameAs Q16846682.
- Brincidofovir sameAs Q16846682.
- Brincidofovir wasDerivedFrom Brincidofovir?oldid=657303967.
- Brincidofovir depiction Brincidofovir.svg.
- Brincidofovir isPrimaryTopicOf Brincidofovir.