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- Blow_fill_seal abstract "Blow-Fill-Seal (BFS) technology is a manufacturing technique used to produce small, (0.1mL) and large volume, (500mL +) liquid-filled containers. Originally developed in Europe in the 1930s, it was introduced in the United States in the 1960s, but over the last 20 years it has become more prevalent within the pharmaceutical industry and is now widely considered to be the superior form of aseptic processing by various medicine regulatory agencies including the U.S. Food and Drug Administration (FDA) in the packaging of pharmaceutical and healthcare products. The basic concept of BFS is that a container is formed, filled, and sealed in a continuous process without human intervention, in a sterile enclosed area inside a machine. Thus this technology can be used to aseptically manufacture sterile pharmaceutical liquid dosage forms. The process is multi-stepped: first, pharmaceutical-grade plastic resin is vertically heat extruded through a circular throat to form a hanging tube called the parison. This extruded tube is then enclosed within a two-part mould, and the tube is cut above the mould. The mould is transferred to the filling zone, or sterile filling space, where filling needles (mandrels) are lowered and used to inflate the plastic to form the container within the mould. Following the formation of the container, the mandrel is used to fill the container with liquid. Following filling the mandrels are retracted and a secondary top mould seals the container. All actions take place inside a sterile shrouded chamber inside the machine. The product is then discharged to a non-sterile area for labeling, packaging and distribution. Blow-fill-seal technology reduces personnel intervention making it a more robust method for the aseptic preparation of sterile pharmaceuticals. BFS is used for the filling of vials for parenteral preparations and infusions, eye drops, and inhalation products. Generally the plastic containers are made up of polyethylene and polypropylene. Polypropylene is more commonly used to form containers which are further sterilised by autoclaving as polypropylene has greater thermostability.".
- Blow_fill_seal wikiPageID "2246651".
- Blow_fill_seal wikiPageLength "2594".
- Blow_fill_seal wikiPageOutDegree "20".
- Blow_fill_seal wikiPageRevisionID "669326959".
- Blow_fill_seal wikiPageWikiLink Asepsis.
- Blow_fill_seal wikiPageWikiLink Aseptic.
- Blow_fill_seal wikiPageWikiLink Aseptic_processing.
- Blow_fill_seal wikiPageWikiLink Autoclave.
- Blow_fill_seal wikiPageWikiLink Autoclaving.
- Blow_fill_seal wikiPageWikiLink Blow_molding.
- Blow_fill_seal wikiPageWikiLink Category:Containers.
- Blow_fill_seal wikiPageWikiLink Category:Food_industry.
- Blow_fill_seal wikiPageWikiLink Category:Pharmaceutical_industry.
- Blow_fill_seal wikiPageWikiLink Europe.
- Blow_fill_seal wikiPageWikiLink Eye_drop.
- Blow_fill_seal wikiPageWikiLink Eye_drops.
- Blow_fill_seal wikiPageWikiLink Food_and_Drug_Administration.
- Blow_fill_seal wikiPageWikiLink Inhalation.
- Blow_fill_seal wikiPageWikiLink Mandrel.
- Blow_fill_seal wikiPageWikiLink Parison.
- Blow_fill_seal wikiPageWikiLink Pharmaceutical_industry.
- Blow_fill_seal wikiPageWikiLink Polyethylene.
- Blow_fill_seal wikiPageWikiLink Polypropylene.
- Blow_fill_seal wikiPageWikiLink Sterile.
- Blow_fill_seal wikiPageWikiLink Sterility.
- Blow_fill_seal wikiPageWikiLink U.S._Food_and_Drug_Administration.
- Blow_fill_seal wikiPageWikiLink United_States.
- Blow_fill_seal wikiPageWikiLink Wikt:parenteral.
- Blow_fill_seal wikiPageWikiLinkText "Blow fill seal".
- Blow_fill_seal wikiPageWikiLinkText "Blow-Fill-Seal".
- Blow_fill_seal hasPhotoCollection Blow_fill_seal.
- Blow_fill_seal wikiPageUsesTemplate Template:Engineering-stub.
- Blow_fill_seal wikiPageUsesTemplate Template:Packaging.
- Blow_fill_seal subject Category:Containers.
- Blow_fill_seal subject Category:Food_industry.
- Blow_fill_seal subject Category:Pharmaceutical_industry.
- Blow_fill_seal hypernym Technique.
- Blow_fill_seal type Article.
- Blow_fill_seal type Software.
- Blow_fill_seal type Article.
- Blow_fill_seal type Container.
- Blow_fill_seal type Industry.
- Blow_fill_seal type Pharmaceutic.
- Blow_fill_seal type Tool.
- Blow_fill_seal comment "Blow-Fill-Seal (BFS) technology is a manufacturing technique used to produce small, (0.1mL) and large volume, (500mL +) liquid-filled containers. Originally developed in Europe in the 1930s, it was introduced in the United States in the 1960s, but over the last 20 years it has become more prevalent within the pharmaceutical industry and is now widely considered to be the superior form of aseptic processing by various medicine regulatory agencies including the U.S.".
- Blow_fill_seal label "Blow fill seal".
- Blow_fill_seal sameAs m.06yz19.
- Blow_fill_seal sameAs Q4928546.
- Blow_fill_seal sameAs Q4928546.
- Blow_fill_seal wasDerivedFrom Blow_fill_seal?oldid=669326959.
- Blow_fill_seal isPrimaryTopicOf Blow_fill_seal.