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- Bence_Jones_protein abstract "A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22-24 kDa. Detection of Bence Jones protein may be suggestive of multiple myeloma or Waldenström's macroglobulinemia.Bence Jones proteins are particularly diagnostic of multiple myeloma in the context of end-organ manifestations such as renal failure, lytic (or "punched out") bone lesions, anemia, or large numbers of plasma cells in the bone marrow of patients. Bence Jones proteins are present in 2/3 of multiple myeloma cases.The proteins are immunoglobulin light chains (paraproteins) and are produced by neoplastic plasma cells. They can be kappa (most of the time) or lambda. The light chains can be immunoglobulin fragments or single homogeneous immunoglobulins. They are found in urine due to the kidneys' decreased filtration capabilities due to renal failure, sometimes induced by hypercalcemia from the calcium released as the bones are destroyed or from the light chains themselves. The light chains have historically been detected by heating a urine specimen (which causes the protein to precipitate) and now by electrophoresis of concentrated urine. More recently serum free light chain assays have been utilised in a number of published studies which have indicated superiority over the urine tests, particularly for patients producing low levels of monoclonal free light chains, as seen in nonsecretory multiple myeloma and AL amyloidosis. This is primarily because of the re-absorption of free light chains in the kidneys, creating a threshold of light chain production which must be exceeded before measurable quantities overflow into the urine. As such, urinalysis is a fickle witness to changing free light chain production.".
- Bence_Jones_protein thumbnail Bence_Jones_Protein_MLE1.jpg?width=300.
- Bence_Jones_protein wikiPageID "2194578".
- Bence_Jones_protein wikiPageLength "5532".
- Bence_Jones_protein wikiPageOutDegree "26".
- Bence_Jones_protein wikiPageRevisionID "676926709".
- Bence_Jones_protein wikiPageWikiLink AL_amyloidosis.
- Bence_Jones_protein wikiPageWikiLink Anemia.
- Bence_Jones_protein wikiPageWikiLink Atomic_mass_unit.
- Bence_Jones_protein wikiPageWikiLink Bone_marrow.
- Bence_Jones_protein wikiPageWikiLink Category:Blood_tests.
- Bence_Jones_protein wikiPageWikiLink Category:Hematology.
- Bence_Jones_protein wikiPageWikiLink Category:Urine_tests.
- Bence_Jones_protein wikiPageWikiLink Electrophoresis.
- Bence_Jones_protein wikiPageWikiLink Fred_Sanger.
- Bence_Jones_protein wikiPageWikiLink Frederick_Sanger.
- Bence_Jones_protein wikiPageWikiLink Globulin.
- Bence_Jones_protein wikiPageWikiLink Henry_Bence_Jones.
- Bence_Jones_protein wikiPageWikiLink Hypercalcaemia.
- Bence_Jones_protein wikiPageWikiLink Hypercalcemia.
- Bence_Jones_protein wikiPageWikiLink Immunoglobulin_light_chain.
- Bence_Jones_protein wikiPageWikiLink Multiple_myeloma.
- Bence_Jones_protein wikiPageWikiLink Myeloma_protein.
- Bence_Jones_protein wikiPageWikiLink Neoplasm.
- Bence_Jones_protein wikiPageWikiLink Neoplastic.
- Bence_Jones_protein wikiPageWikiLink Paraprotein.
- Bence_Jones_protein wikiPageWikiLink Plasma_cell.
- Bence_Jones_protein wikiPageWikiLink Plasma_cells.
- Bence_Jones_protein wikiPageWikiLink Protein.
- Bence_Jones_protein wikiPageWikiLink Renal_failure.
- Bence_Jones_protein wikiPageWikiLink Serum_Free_Light_Chain_Measurement.
- Bence_Jones_protein wikiPageWikiLink Serum_free_light-chain_measurement.
- Bence_Jones_protein wikiPageWikiLink Urine.
- Bence_Jones_protein wikiPageWikiLink Waldenstrxc3xb6ms_macroglobulinemia.
- Bence_Jones_protein wikiPageWikiLink File:Bence_Jones_Protein_MLE1.jpg.
- Bence_Jones_protein wikiPageWikiLinkText "Bence Jones protein".
- Bence_Jones_protein hasPhotoCollection Bence_Jones_protein.
- Bence_Jones_protein wikiPageUsesTemplate Template:Amyloidosis.
- Bence_Jones_protein wikiPageUsesTemplate Template:Citation_needed.
- Bence_Jones_protein wikiPageUsesTemplate Template:Eponymous_medical_signs_for_hematology_and_oncology.
- Bence_Jones_protein wikiPageUsesTemplate Template:Redirect.
- Bence_Jones_protein wikiPageUsesTemplate Template:Reflist.
- Bence_Jones_protein subject Category:Blood_tests.
- Bence_Jones_protein subject Category:Hematology.
- Bence_Jones_protein subject Category:Urine_tests.
- Bence_Jones_protein hypernym Protein.
- Bence_Jones_protein type Article.
- Bence_Jones_protein type Protein.
- Bence_Jones_protein type Article.
- Bence_Jones_protein type Specialty.
- Bence_Jones_protein comment "A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22-24 kDa. Detection of Bence Jones protein may be suggestive of multiple myeloma or Waldenström's macroglobulinemia.Bence Jones proteins are particularly diagnostic of multiple myeloma in the context of end-organ manifestations such as renal failure, lytic (or "punched out") bone lesions, anemia, or large numbers of plasma cells in the bone marrow of patients.".
- Bence_Jones_protein label "Bence Jones protein".
- Bence_Jones_protein sameAs Proteïna_de_Bence_Jones.
- Bence_Jones_protein sameAs Bence-Jones-Protein.
- Bence_Jones_protein sameAs Proteína_de_Bence_Jones.
- Bence_Jones_protein sameAs Protéine_de_Bence-Jones.
- Bence_Jones_protein sameAs Proteina_di_Bence_Jones.
- Bence_Jones_protein sameAs Biaxc5x82ko_Bencea-Jonesa.
- Bence_Jones_protein sameAs m.06v05w.
- Bence_Jones_protein sameAs பென்ஸ்_ஜோன்ஸ்_புரதம்.
- Bence_Jones_protein sameAs Q424176.
- Bence_Jones_protein sameAs Q424176.
- Bence_Jones_protein wasDerivedFrom Bence_Jones_protein?oldid=676926709.
- Bence_Jones_protein depiction Bence_Jones_Protein_MLE1.jpg.
- Bence_Jones_protein isPrimaryTopicOf Bence_Jones_protein.