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- Barbiturate_dependence abstract "Barbiturate dependence develops with regular use of barbiturates. This in turn may lead to a need for increasing doses of the drug to get the original desired pharmacological or therapeutic effect. Barbiturate use can lead to both addiction and physical dependence, and as such they have a high potential for abuse. Psychological addiction to barbiturates can develop quickly. The GABAA receptor, one of barbiturates' main sites of action, is thought to play a pivotal role in the development of tolerance to and dependence on barbiturates, as well as the euphoric "high" that results from their abuse. The mechanism by which barbiturate tolerance develops is believed to be different from that of ethanol or benzodiazepines, even though these drugs have been shown to exhibit cross-tolerance with each other. The management of a physical dependence on barbiturates is stabilisation on the long-acting barbiturate phenobarbital followed by a gradual titration down of dose. The slowly eliminated phenobarbital lessens the severity of the withdrawal syndrome and reduces the chances of serious barbiturate withdrawal effects such as seizures. Antipsychotics are not recommended for barbiturate withdrawal (or other CNS depressant withdrawal states) especially clozapine, olanzapine or low potency phenothiazines e.g. chlorpromazine as they lower the seizure threshold and can worsen withdrawal effects; if used extreme caution is required.".
- Barbiturate_dependence wikiPageID "26983756".
- Barbiturate_dependence wikiPageLength "3631".
- Barbiturate_dependence wikiPageOutDegree "15".
- Barbiturate_dependence wikiPageRevisionID "665641155".
- Barbiturate_dependence wikiPageWikiLink Addiction.
- Barbiturate_dependence wikiPageWikiLink Barbiturate.
- Barbiturate_dependence wikiPageWikiLink Benzodiazepine.
- Barbiturate_dependence wikiPageWikiLink Benzodiazepines.
- Barbiturate_dependence wikiPageWikiLink Category:Barbiturates.
- Barbiturate_dependence wikiPageWikiLink Category:Substance_dependence.
- Barbiturate_dependence wikiPageWikiLink Chlorpromazine.
- Barbiturate_dependence wikiPageWikiLink Clozapine.
- Barbiturate_dependence wikiPageWikiLink Ethanol.
- Barbiturate_dependence wikiPageWikiLink Euphoria.
- Barbiturate_dependence wikiPageWikiLink GABAA_receptor.
- Barbiturate_dependence wikiPageWikiLink Olanzapine.
- Barbiturate_dependence wikiPageWikiLink Phenobarbital.
- Barbiturate_dependence wikiPageWikiLink Phenothiazine.
- Barbiturate_dependence wikiPageWikiLink Phenothiazines.
- Barbiturate_dependence wikiPageWikiLink Physical_dependence.
- Barbiturate_dependence wikiPageWikiLinkText "Barbiturate dependence".
- Barbiturate_dependence wikiPageWikiLinkText "Barbiturate dependence".
- Barbiturate_dependence wikiPageWikiLinkText "barbiturate dependence".
- Barbiturate_dependence hasPhotoCollection Barbiturate_dependence.
- Barbiturate_dependence icd "304.1".
- Barbiturate_dependence icd "F13.2".
- Barbiturate_dependence name "Barbiturate dependence".
- Barbiturate_dependence wikiPageUsesTemplate Template:Addiction.
- Barbiturate_dependence wikiPageUsesTemplate Template:Disease-stub.
- Barbiturate_dependence wikiPageUsesTemplate Template:Infobox_Disease.
- Barbiturate_dependence wikiPageUsesTemplate Template:Psychoactive_substance_use.
- Barbiturate_dependence wikiPageUsesTemplate Template:Reflist.
- Barbiturate_dependence subject Category:Barbiturates.
- Barbiturate_dependence subject Category:Substance_dependence.
- Barbiturate_dependence type Disease.
- Barbiturate_dependence type Anticonvulsant.
- Barbiturate_dependence type Disorder.
- Barbiturate_dependence type Imide.
- Barbiturate_dependence type Thing.
- Barbiturate_dependence type Q12136.
- Barbiturate_dependence comment "Barbiturate dependence develops with regular use of barbiturates. This in turn may lead to a need for increasing doses of the drug to get the original desired pharmacological or therapeutic effect. Barbiturate use can lead to both addiction and physical dependence, and as such they have a high potential for abuse. Psychological addiction to barbiturates can develop quickly.".
- Barbiturate_dependence label "Barbiturate dependence".
- Barbiturate_dependence sameAs バルビツール酸系依存症.
- Barbiturate_dependence sameAs m.0bs3c19.
- Barbiturate_dependence sameAs Барбитуризм.
- Barbiturate_dependence sameAs Q4261984.
- Barbiturate_dependence sameAs Q4261984.
- Barbiturate_dependence wasDerivedFrom Barbiturate_dependence?oldid=665641155.
- Barbiturate_dependence isPrimaryTopicOf Barbiturate_dependence.