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- Bacteriocin_IId abstract "Bacteriocin AS-48 is a cyclic peptide antibiotic produced by the eubacteria Enterococcus faecalis (Streptococcus faecalis) that shows a broad antimicrobial spectrum against both Gram-positive and Gram-negative bacteria. Bacteriocin AS-48 is encoded by the pheromone-responsive plasmid pMB2, and acts on the plasma membrane in which it opens pores leading to ion leakage and cell death. The globular structure of bacteriocin AS-48 is composed of five alpha helices enclosing a hydrophobic core. The mammalian NK-lysin effector protein of T and natural killer cells has a similar structure, though it lacks sequence homology with bacteriocins AS-48.Bacteriocin uses components of the mannose phosphotransferase system (man-PTS) of susceptible cells as target/receptor. The immmunity protein LciA forms a strong complex with the receptor proteins and the bacteriocin, thereby preventing cells from being killed. The complex between LciA and the man-PTS components (IIAB, IIC, and IID) appears to involve an on–off type mechanism that allows complex formation only in the presence of bacteriocin; otherwise no complexes were observed between LciA and the receptor proteins.".
- Bacteriocin_IId symbol "Bacteriocin_IId".
- Bacteriocin_IId thumbnail PDB_1o82_EBI.jpg?width=300.
- Bacteriocin_IId wikiPageID "36334864".
- Bacteriocin_IId wikiPageLength "2609".
- Bacteriocin_IId wikiPageOutDegree "23".
- Bacteriocin_IId wikiPageRevisionID "590728324".
- Bacteriocin_IId wikiPageWikiLink Alpha_helix.
- Bacteriocin_IId wikiPageWikiLink Antibiotic.
- Bacteriocin_IId wikiPageWikiLink Antibiotics.
- Bacteriocin_IId wikiPageWikiLink Bacteria.
- Bacteriocin_IId wikiPageWikiLink Bacteriocin.
- Bacteriocin_IId wikiPageWikiLink Bacteriocins.
- Bacteriocin_IId wikiPageWikiLink Biomolecular_structure.
- Bacteriocin_IId wikiPageWikiLink Category:Protein_domains.
- Bacteriocin_IId wikiPageWikiLink Cell_(biology).
- Bacteriocin_IId wikiPageWikiLink Cell_death.
- Bacteriocin_IId wikiPageWikiLink Cell_membrane.
- Bacteriocin_IId wikiPageWikiLink Effector_(biology).
- Bacteriocin_IId wikiPageWikiLink Gram-negative.
- Bacteriocin_IId wikiPageWikiLink Gram-negative_bacteria.
- Bacteriocin_IId wikiPageWikiLink Gram-positive.
- Bacteriocin_IId wikiPageWikiLink Gram-positive_bacteria.
- Bacteriocin_IId wikiPageWikiLink Homology_(biology).
- Bacteriocin_IId wikiPageWikiLink Hydrophobic_core.
- Bacteriocin_IId wikiPageWikiLink Hydrophobic_effect.
- Bacteriocin_IId wikiPageWikiLink Ion.
- Bacteriocin_IId wikiPageWikiLink Mammal.
- Bacteriocin_IId wikiPageWikiLink Mammalia.
- Bacteriocin_IId wikiPageWikiLink Mannose_phosphotransferase.
- Bacteriocin_IId wikiPageWikiLink Peptide.
- Bacteriocin_IId wikiPageWikiLink Pheromone.
- Bacteriocin_IId wikiPageWikiLink Plasmid.
- Bacteriocin_IId wikiPageWikiLink Protein.
- Bacteriocin_IId wikiPageWikiLink Secondary_structure.
- Bacteriocin_IId wikiPageWikiLink Sequence_homology.
- Bacteriocin_IId wikiPageWikiLink Zinc-dependent_phospholipase_C.
- Bacteriocin_IId wikiPageWikiLink Zinc_dependent_phospholipase_C.
- Bacteriocin_IId caption "x-ray structure of bacteriocin as-48 at ph 4.5. sulphate bound form".
- Bacteriocin_IId hasPhotoCollection Bacteriocin_IId.
- Bacteriocin_IId interpro "IPR009086".
- Bacteriocin_IId name "Bacteriocin_IId".
- Bacteriocin_IId pfam "PF09221".
- Bacteriocin_IId scop "1".
- Bacteriocin_IId symbol "Bacteriocin_IId".
- Bacteriocin_IId tcdb "1".
- Bacteriocin_IId wikiPageUsesTemplate Template:Infobox_protein_family.
- Bacteriocin_IId wikiPageUsesTemplate Template:InterPro_content.
- Bacteriocin_IId wikiPageUsesTemplate Template:Reflist.
- Bacteriocin_IId subject Category:Protein_domains.
- Bacteriocin_IId type Biomolecule.
- Bacteriocin_IId type Protein.
- Bacteriocin_IId type Chemical.
- Bacteriocin_IId type Domain.
- Bacteriocin_IId type Thing.
- Bacteriocin_IId type Q206229.
- Bacteriocin_IId type Q8054.
- Bacteriocin_IId comment "Bacteriocin AS-48 is a cyclic peptide antibiotic produced by the eubacteria Enterococcus faecalis (Streptococcus faecalis) that shows a broad antimicrobial spectrum against both Gram-positive and Gram-negative bacteria. Bacteriocin AS-48 is encoded by the pheromone-responsive plasmid pMB2, and acts on the plasma membrane in which it opens pores leading to ion leakage and cell death. The globular structure of bacteriocin AS-48 is composed of five alpha helices enclosing a hydrophobic core.".
- Bacteriocin_IId label "Bacteriocin IId".
- Bacteriocin_IId sameAs m.0k3m_91.
- Bacteriocin_IId sameAs Q4840014.
- Bacteriocin_IId sameAs Q4840014.
- Bacteriocin_IId wasDerivedFrom Bacteriocin_IId?oldid=590728324.
- Bacteriocin_IId depiction PDB_1o82_EBI.jpg.
- Bacteriocin_IId isPrimaryTopicOf Bacteriocin_IId.