Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/BIT225> ?p ?o }
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- BIT225 abstract "BIT225 is an experimental drug candidate under development by Biotron Limited for use in the treatment of both HIV and hepatitis C infection. By blocking Vpu ion channel activity, it disrupts HIV assembly within host monocyte cells; its method of action is a first for HIV drugs. Because it targets replication in monocyte derived macrophages, it offers promise for treatment of viral reservoirs that are unaffected by standard treatments. The activity of BIT225 is post-virus integration, with no direct effects on the HIV enzymes reverse transcriptase and protease. Since Vpu ion channel activity is highly conserved, the virus is unlikely to become resistant via generation of Vpu ion-independent virus. In addition, the drug also has been credited with curing hepatitis C after 12 weeks of treatment.".
- BIT225 iupacName "N-Carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide".
- BIT225 thumbnail BIT225.svg?width=300.
- BIT225 wikiPageID "44104129".
- BIT225 wikiPageLength "2425".
- BIT225 wikiPageOutDegree "14".
- BIT225 wikiPageRevisionID "629724153".
- BIT225 wikiPageWikiLink Biotron_Limited.
- BIT225 wikiPageWikiLink Category:Antiretroviral_drugs.
- BIT225 wikiPageWikiLink Category:Guanidines.
- BIT225 wikiPageWikiLink Category:Pyrazoles.
- BIT225 wikiPageWikiLink HIV.
- BIT225 wikiPageWikiLink Hepatitis_C.
- BIT225 wikiPageWikiLink Macrophage.
- BIT225 wikiPageWikiLink Macrophages.
- BIT225 wikiPageWikiLink Mechanism_(engineering).
- BIT225 wikiPageWikiLink Method_of_action.
- BIT225 wikiPageWikiLink Monocyte.
- BIT225 wikiPageWikiLink Protease.
- BIT225 wikiPageWikiLink Reverse_transcriptase.
- BIT225 wikiPageWikiLink Vpu.
- BIT225 wikiPageWikiLinkText "BIT225".
- BIT225 hasPhotoCollection BIT225.
- BIT225 imagefile "BIT225.svg".
- BIT225 imagesize "200".
- BIT225 iupacname "N-Carbamimidoyl-5--2-naphthamide".
- BIT225 othernames "BIT-225".
- BIT225 wikiPageUsesTemplate Template:Chembox.
- BIT225 wikiPageUsesTemplate Template:Reflist.
- BIT225 subject Category:Antiretroviral_drugs.
- BIT225 subject Category:Guanidines.
- BIT225 subject Category:Pyrazoles.
- BIT225 hypernym Candidate.
- BIT225 type ChemicalCompound.
- BIT225 type ChemicalSubstance.
- BIT225 type Person.
- BIT225 type ChemicalObject.
- BIT225 type Thing.
- BIT225 type Q11173.
- BIT225 comment "BIT225 is an experimental drug candidate under development by Biotron Limited for use in the treatment of both HIV and hepatitis C infection. By blocking Vpu ion channel activity, it disrupts HIV assembly within host monocyte cells; its method of action is a first for HIV drugs. Because it targets replication in monocyte derived macrophages, it offers promise for treatment of viral reservoirs that are unaffected by standard treatments.".
- BIT225 label "BIT225".
- BIT225 sameAs m.0123knnq.
- BIT225 sameAs Q18355839.
- BIT225 sameAs Q18355839.
- BIT225 wasDerivedFrom BIT225?oldid=629724153.
- BIT225 depiction BIT225.svg.
- BIT225 isPrimaryTopicOf BIT225.