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- BIIE-0246 abstract "BIIE-0246 is a drug used in scientific research which acts as a potent and selective antagonist for the Neuropeptide Y receptor Y2. It was one of the first non-peptide Y2-selective antagonists developed, and remains among the most widely used tools for studying this receptor. It has been used to demonstrate a role for the Y2 subtype as a presynaptic autoreceptor limiting further neuropeptide Y release, as well as modulating dopamine and acetylcholine release. It has also been shown to produce several behavioural effects in animals, including reducing alcohol consumption in addicted rats and anxiolytic effects, although while selective Y2 agonists are expected to be useful as anorectics, BIIE-0246 did not appear to increase appetite when administered alone.".
- BIIE-0246 casNumber "246146-55-4".
- BIIE-0246 iupacName "N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[([2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino)carbonyl]butyl]-1-(2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl)cyclopentaneacetamide".
- BIIE-0246 pubchem "9811493".
- BIIE-0246 thumbnail BIIE-0246_structure.png?width=300.
- BIIE-0246 wikiPageID "22518920".
- BIIE-0246 wikiPageLength "7848".
- BIIE-0246 wikiPageOutDegree "6".
- BIIE-0246 wikiPageRevisionID "590766130".
- BIIE-0246 wikiPageWikiLink Anorectic.
- BIIE-0246 wikiPageWikiLink Anxiolytic.
- BIIE-0246 wikiPageWikiLink Category:Neuropeptide_Y_antagonists.
- BIIE-0246 wikiPageWikiLink Neuropeptide_Y.
- BIIE-0246 wikiPageWikiLink Neuropeptide_Y_receptor_Y2.
- BIIE-0246 wikiPageWikiLink Receptor_antagonist.
- BIIE-0246 wikiPageWikiLinkText "BIIE-0246".
- BIIE-0246 c "49".
- BIIE-0246 casNumber "246146".
- BIIE-0246 chemspiderid "7987248".
- BIIE-0246 h "57".
- BIIE-0246 hasPhotoCollection BIIE-0246.
- BIIE-0246 inchi "1".
- BIIE-0246 inchikey "RSJAXPUYVJKAAA-JPGJPTAEBV".
- BIIE-0246 iupacName "N-[-4-[amino]-1-[carbonyl]butyl]-1-cyclopentaneacetamide".
- BIIE-0246 iupharLigand "1547".
- BIIE-0246 molecularWeight "896.045".
- BIIE-0246 n "11".
- BIIE-0246 o "6".
- BIIE-0246 pubchem "9811493".
- BIIE-0246 smiles "O=C3NNCN3CCNC[C@@H]CCC/N=CN".
- BIIE-0246 stdinchi "1".
- BIIE-0246 stdinchikey "RSJAXPUYVJKAAA-JPGJPTAESA-N".
- BIIE-0246 synonyms "BIIE-0246".
- BIIE-0246 verifiedfields "changed".
- BIIE-0246 verifiedrevid "449571990".
- BIIE-0246 watchedfields "changed".
- BIIE-0246 width "300".
- BIIE-0246 wikiPageUsesTemplate Template:Drugbox.
- BIIE-0246 wikiPageUsesTemplate Template:Neuropeptide_agonists_and_antagonists.
- BIIE-0246 wikiPageUsesTemplate Template:Reflist.
- BIIE-0246 subject Category:Neuropeptide_Y_antagonists.
- BIIE-0246 hypernym Drug.
- BIIE-0246 type Article.
- BIIE-0246 type ChemicalSubstance.
- BIIE-0246 type Drug.
- BIIE-0246 type Antagonist.
- BIIE-0246 type Article.
- BIIE-0246 type Neuropeptide.
- BIIE-0246 type ChemicalObject.
- BIIE-0246 type Thing.
- BIIE-0246 type Q8386.
- BIIE-0246 comment "BIIE-0246 is a drug used in scientific research which acts as a potent and selective antagonist for the Neuropeptide Y receptor Y2. It was one of the first non-peptide Y2-selective antagonists developed, and remains among the most widely used tools for studying this receptor. It has been used to demonstrate a role for the Y2 subtype as a presynaptic autoreceptor limiting further neuropeptide Y release, as well as modulating dopamine and acetylcholine release.".
- BIIE-0246 label "BIIE-0246".
- BIIE-0246 sameAs m.05zzq6g.
- BIIE-0246 sameAs BIIE-0246.
- BIIE-0246 sameAs BIIE-0246.
- BIIE-0246 sameAs Q4835683.
- BIIE-0246 sameAs Q4835683.
- BIIE-0246 wasDerivedFrom BIIE-0246?oldid=590766130.
- BIIE-0246 depiction BIIE-0246_structure.png.
- BIIE-0246 isPrimaryTopicOf BIIE-0246.