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- Axelopran abstract "Axelopran (INN, USAN) (developmental code name TD-1211) is a drug which is under development by Theravance Biopharma for the treatment of opioid-induced constipation. It acts as a potent, selective, and peripherally-restricted μ-, κ-, and δ-opioid receptor antagonist, with similar affinity for the μ- and κ-opioid receptors and about an order of magnitude lower affinity for the δ-opioid receptor. Axelopran has potent μ-opioid receptor antagonist activity on the gastrointestinal tract in vivo, and thus it produces a dose-dependent inhibition of opioid-induced delaying in gastric emptying in mice and rats following subcutaneous or oral administration.".
- Axelopran casNumber "949904-48-7".
- Axelopran casSupplemental "949904-50-1 (sulfate)".
- Axelopran iupacName "3-[(1R,5S)-8-[2-[cyclohexylmethyl-[(2S)-2,3-dihydroxypropanoyl]amino]ethyl]-8-azabicyclo[3.2.1]octan-3-yl]benzamide".
- Axelopran pubchem "67156338".
- Axelopran thumbnail Axelopran_structure.png?width=300.
- Axelopran wikiPageID "46886788".
- Axelopran wikiPageLength "3056".
- Axelopran wikiPageOutDegree "25".
- Axelopran wikiPageRevisionID "666841913".
- Axelopran wikiPageWikiLink Affinity_(pharmacology).
- Axelopran wikiPageWikiLink Alvimopan.
- Axelopran wikiPageWikiLink Category:Drugs_acting_on_the_gastrointestinal_system_and_metabolism.
- Axelopran wikiPageWikiLink Category:Kappa_antagonists.
- Axelopran wikiPageWikiLink Category:Laxatives.
- Axelopran wikiPageWikiLink Category:Opioid_antagonists.
- Axelopran wikiPageWikiLink Constipation.
- Axelopran wikiPageWikiLink Digestion.
- Axelopran wikiPageWikiLink Drug.
- Axelopran wikiPageWikiLink Eluxadoline.
- Axelopran wikiPageWikiLink Gastrointestinal_tract.
- Axelopran wikiPageWikiLink In_vivo.
- Axelopran wikiPageWikiLink International_Nonproprietary_Name.
- Axelopran wikiPageWikiLink Ligand_(biochemistry).
- Axelopran wikiPageWikiLink Methylnaltrexone.
- Axelopran wikiPageWikiLink Mouth.
- Axelopran wikiPageWikiLink Naldemedine.
- Axelopran wikiPageWikiLink Naloxegol.
- Axelopran wikiPageWikiLink Opioid.
- Axelopran wikiPageWikiLink Receptor_antagonist.
- Axelopran wikiPageWikiLink Subcutaneous.
- Axelopran wikiPageWikiLink Sulfate.
- Axelopran wikiPageWikiLink Theravance_Biopharma.
- Axelopran wikiPageWikiLink United_States_Adopted_Name.
- Axelopran wikiPageWikiLink Δ-opioid_receptor.
- Axelopran wikiPageWikiLink Κ-opioid_receptor.
- Axelopran wikiPageWikiLink Μ-opioid_receptor.
- Axelopran wikiPageWikiLinkText "Axelopran".
- Axelopran c "26".
- Axelopran casNumber "949904".
- Axelopran casSupplemental "949904".
- Axelopran chemspiderid "31444004".
- Axelopran h "39".
- Axelopran hasPhotoCollection Axelopran.
- Axelopran inchi "InChI=1S/C26H39N3O4/c27-2520-8-4-7-1921-14-22-9-10-232912-11-2816-18-5-2-1-3-6-18/h4,7-8,13,18,21-24,30-31H,1-3,5-6,9-12,14-17H2,/t21?,22-,23+,24-/m0/s1".
- Axelopran inchikey "ATLYLVPZNWDJBW-NHYNNZIHSA-N".
- Axelopran iupacName "3".
- Axelopran molecularWeight "457.60556".
- Axelopran n "3".
- Axelopran o "4".
- Axelopran pubchem "67156338".
- Axelopran smiles "C1CCCCNCCO".
- Axelopran width "240".
- Axelopran wikiPageUsesTemplate Template:Drugbox.
- Axelopran wikiPageUsesTemplate Template:Gastrointestinal-drug-stub.
- Axelopran wikiPageUsesTemplate Template:Laxatives.
- Axelopran wikiPageUsesTemplate Template:Opioidergics.
- Axelopran wikiPageUsesTemplate Template:Refimprove.
- Axelopran wikiPageUsesTemplate Template:Reflist.
- Axelopran subject Category:Drugs_acting_on_the_gastrointestinal_system_and_metabolism.
- Axelopran subject Category:Kappa_antagonists.
- Axelopran subject Category:Laxatives.
- Axelopran subject Category:Opioid_antagonists.
- Axelopran hypernym Drug.
- Axelopran type ChemicalSubstance.
- Axelopran type Drug.
- Axelopran type ChemicalObject.
- Axelopran type Thing.
- Axelopran type Q8386.
- Axelopran comment "Axelopran (INN, USAN) (developmental code name TD-1211) is a drug which is under development by Theravance Biopharma for the treatment of opioid-induced constipation. It acts as a potent, selective, and peripherally-restricted μ-, κ-, and δ-opioid receptor antagonist, with similar affinity for the μ- and κ-opioid receptors and about an order of magnitude lower affinity for the δ-opioid receptor.".
- Axelopran label "Axelopran".
- Axelopran sameAs m.013ccqgh.
- Axelopran sameAs Q20707800.
- Axelopran sameAs Q20707800.
- Axelopran wasDerivedFrom Axelopran?oldid=666841913.
- Axelopran depiction Axelopran_structure.png.
- Axelopran isPrimaryTopicOf Axelopran.