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- Autoimmune_neutropenia abstract "Autoimmune neutropenia is a form of neutropenia which is most common in infants and young children where the body identifies the neutrophils as enemies and makes antibody to destroy them. Primary autoimmune neutropenia (AIN) is an autoimmune disease first reported in 1975 that primarily occurs in infancy. In autoimmune neutropenia, the immune system produces autoantibodies directed against the neutrophilic protein antigens in white blood cells known as granulocytic neutrophils (granulocytes, segmented neutrophils, segs, polysegmented neutrophils, polys). These antibodies destroy granulocytic neutrophils. Consequently, patients with autoimmune neutropenia have low levels of granulocytic neutrophilic white blood cells causing a condition of neutropenia. Neutropenia causes an increased risk of infection from organisms that the body could normally fight easily.Who is Affected?Primary autoimmune neutropenia has been reported as early as the second month of life although most cases are diagnosed in children between 5 and 15 months of age. Girls have a slightly higher risk of developing AIN than boys. In neutropenia discovered at birth or shortly after birth, a diagnosis of allo-immune neutropenia (from maternal white blood cell antibodies passively transferred to the infant) is more likely.NeutropeniaIn infants neutropenia is defined by absolute neutrophil counts less than 1000/uL. After the first year of life neutropenia is defined by absolute counts less than 1500/uL. Neutropenia may be primary in which is the only blood abnormality seen. In secondary neutropenia, other primary conditions occur, including other autoimmune diseases, infections, and malignancies. Neutropenia is considered chronic when it persists for more than 6 months.Symptoms and Disease CourseNeutropenia, which may be discovered on routine blood tests, typically causes benign infections even when the condition is severe. Ear infections (otitis media) are the most common infection seen in autoimmune neutropenia and typically infection responds to antibiotic treatment alone. Infections associated with primary AIN are usually mild and limited, including skin infections such as impetigo, gastroenteritis, upper respiratory tract infections, and ear infections. Rarely, cellulitis and abscesses may occur.Studies of children studied for up to six years showed that most cases of autoimmune neutropenia resolved spontaneously after a median of 17 months. In 80 percent of patients, neutropenia persisted for 7 to 24 months.DiagnosisPatients with autoimmune neutropenia are diagnosed on the basis of blood tests showing neutropenia and the presence of granulocyte-specific antibodies. In some cases, tests for granulocyte-specific antibodies need to be repeated several times before a positive result is seen. Bone marrow aspiration, if performed, is typically normal or it can show increased cell production with a variably diminished number of segmented granulocytes.s association with prior parvovirus B19 has been made but this hasn’t been confirmed. Similar to the platelet deficiency idiopathic thrombocytopenic purpura, vaccines are suspected of triggering this disorder.TreatmentTreatment consists of corticosteroids to reduce autoantibody production, antibiotics to prevent infection and granulocyte colony-stimulating factor (G-CSF) to temporarily increase neutrophil counts. In cases of severe infection or the need for surgery, intravenous immunoglobulin therapy may be used.".
- Autoimmune_neutropenia wikiPageExternalLink PMC1257445.
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- Autoimmune_neutropenia wikiPageOutDegree "7".
- Autoimmune_neutropenia wikiPageRevisionID "664292427".
- Autoimmune_neutropenia wikiPageWikiLink Antibiotic.
- Autoimmune_neutropenia wikiPageWikiLink Antibiotics.
- Autoimmune_neutropenia wikiPageWikiLink Antibodies.
- Autoimmune_neutropenia wikiPageWikiLink Antibody.
- Autoimmune_neutropenia wikiPageWikiLink Autoimmune_disease.
- Autoimmune_neutropenia wikiPageWikiLink Category:Monocyte_and_granulocyte_disorders.
- Autoimmune_neutropenia wikiPageWikiLink Diagnosis.
- Autoimmune_neutropenia wikiPageWikiLink Neutropenia.
- Autoimmune_neutropenia wikiPageWikiLink Preventive_healthcare.
- Autoimmune_neutropenia wikiPageWikiLink Prophylactic.
- Autoimmune_neutropenia wikiPageWikiLinkText "Autoimmune neutropenia".
- Autoimmune_neutropenia wikiPageWikiLinkText "autoimmune neutropenia".
- Autoimmune_neutropenia diseasesdb "32421".
- Autoimmune_neutropenia emedicinesubj "ped".
- Autoimmune_neutropenia emedicinetopic "184".
- Autoimmune_neutropenia hasPhotoCollection Autoimmune_neutropenia.
- Autoimmune_neutropenia icd "288.09".
- Autoimmune_neutropenia name "Autoimmune neutropenia".
- Autoimmune_neutropenia wikiPageUsesTemplate Template:Cleanup-reorganize.
- Autoimmune_neutropenia wikiPageUsesTemplate Template:Fact.
- Autoimmune_neutropenia wikiPageUsesTemplate Template:Infobox_Disease.
- Autoimmune_neutropenia wikiPageUsesTemplate Template:Reflist.
- Autoimmune_neutropenia subject Category:Monocyte_and_granulocyte_disorders.
- Autoimmune_neutropenia hypernym Form.
- Autoimmune_neutropenia type Article.
- Autoimmune_neutropenia type Article.
- Autoimmune_neutropenia type Disorder.
- Autoimmune_neutropenia comment "Autoimmune neutropenia is a form of neutropenia which is most common in infants and young children where the body identifies the neutrophils as enemies and makes antibody to destroy them. Primary autoimmune neutropenia (AIN) is an autoimmune disease first reported in 1975 that primarily occurs in infancy.".
- Autoimmune_neutropenia label "Autoimmune neutropenia".
- Autoimmune_neutropenia sameAs m.03nwly2.
- Autoimmune_neutropenia sameAs Q17145912.
- Autoimmune_neutropenia sameAs Q17145912.
- Autoimmune_neutropenia wasDerivedFrom Autoimmune_neutropenia?oldid=664292427.
- Autoimmune_neutropenia isPrimaryTopicOf Autoimmune_neutropenia.