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- Atacicept abstract "Atacicept is a recombinant fusion protein designed to inhibit B cells, thereby suppressing autoimmune disease. The designer protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells, B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), with the constant region of immunoglobin. Atacicept blocks activation of B cells by the tumor necrosis factor receptor superfamily member 13B (more commonly known as TACI), a transmembrane receptor protein found predominantly on the surface of B cells. Like the monoclonal antibody belimumab, atacicept blocks the binding of BLyS, but it also blocks APRIL. Binding of these TACI ligands induces proliferation, activation, and longevity of B cells and thus their production of autoantibodies. Atacicept is thought to selectively impair mature B cells and plasma cells with less impact on progenitor cells and memory B cells.Studies have looked at atacicept in animal models of autoimmune disease and in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and optic neuritis. A phase II/III trial for systemic lupus erythematosus is due to run from 2008 to 2012. The subcutaneously injected protein failed a phase II trial for multiple sclerosis. The trials of atacicept in people with MS were suspended when some people taking the drug in one trial had an unexpected increase in inflammatory activity. An independent data monitoring board for the MS study found "subjects receiving atacicept were having more relapses and new MRI lesions than those on the placebo."The drug is also being studied for treatment of B-cell malignancies, including multiple myeloma, B-cell chronic lymphocytic leukemia, and non-Hodgkin's lymphoma.Atacicept was developed by a Seattle-based biotech company, ZymoGenetics, which handed the product over to Merck Serono for further development.".
- Atacicept atcPrefix "none".
- Atacicept casNumber "845264-92-8".
- Atacicept fdaUniiCode "K3D9A0ICQ3".
- Atacicept wikiPageID "28043973".
- Atacicept wikiPageLength "5042".
- Atacicept wikiPageOutDegree "20".
- Atacicept wikiPageRevisionID "659798506".
- Atacicept wikiPageWikiLink APRIL_(protein).
- Atacicept wikiPageWikiLink A_proliferation-inducing_ligand.
- Atacicept wikiPageWikiLink Antibody.
- Atacicept wikiPageWikiLink Atomic_mass_unit.
- Atacicept wikiPageWikiLink Autoantibodies.
- Atacicept wikiPageWikiLink Autoantibody.
- Atacicept wikiPageWikiLink Autoimmune_disease.
- Atacicept wikiPageWikiLink B-cell_activating_factor.
- Atacicept wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
- Atacicept wikiPageWikiLink B-lymphocyte_stimulator.
- Atacicept wikiPageWikiLink B_cell.
- Atacicept wikiPageWikiLink Belimumab.
- Atacicept wikiPageWikiLink Category:Engineered_proteins.
- Atacicept wikiPageWikiLink Cytokine.
- Atacicept wikiPageWikiLink Fusion_protein.
- Atacicept wikiPageWikiLink Immunoglobin.
- Atacicept wikiPageWikiLink KDa.
- Atacicept wikiPageWikiLink Memory_B_cell.
- Atacicept wikiPageWikiLink Monoclonal_antibody.
- Atacicept wikiPageWikiLink Multiple_myeloma.
- Atacicept wikiPageWikiLink Multiple_sclerosis.
- Atacicept wikiPageWikiLink Non-Hodgkin_lymphoma.
- Atacicept wikiPageWikiLink Non-Hodgkins_lymphoma.
- Atacicept wikiPageWikiLink Progenitor_cell.
- Atacicept wikiPageWikiLink Recombinant_fusion_protein.
- Atacicept wikiPageWikiLink Systemic_lupus_erythematosus.
- Atacicept wikiPageWikiLink TACI.
- Atacicept wikiPageWikiLink Transmembrane_activator_and_CAML_interactor.
- Atacicept wikiPageWikiLinkText "Atacicept".
- Atacicept wikiPageWikiLinkText "atacicept".
- Atacicept atcPrefix "none".
- Atacicept casNumber "845264".
- Atacicept chemspiderid "NA".
- Atacicept hasPhotoCollection Atacicept.
- Atacicept legalStatus "Investigational".
- Atacicept molecularWeight "71".
- Atacicept unii "K3D9A0ICQ3".
- Atacicept verifiedfields "changed".
- Atacicept verifiedrevid "459589892".
- Atacicept wikiPageUsesTemplate Template:Drugbox.
- Atacicept wikiPageUsesTemplate Template:Reflist.
- Atacicept subject Category:Engineered_proteins.
- Atacicept hypernym Protein.
- Atacicept type Article.
- Atacicept type ChemicalSubstance.
- Atacicept type Drug.
- Atacicept type Protein.
- Atacicept type Article.
- Atacicept type Chemical.
- Atacicept type Drug.
- Atacicept type ChemicalObject.
- Atacicept type Thing.
- Atacicept type Q8386.
- Atacicept comment "Atacicept is a recombinant fusion protein designed to inhibit B cells, thereby suppressing autoimmune disease. The designer protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells, B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), with the constant region of immunoglobin.".
- Atacicept label "Atacicept".
- Atacicept sameAs Atacicept.
- Atacicept sameAs Atacicept.
- Atacicept sameAs m.0cmc32_.
- Atacicept sameAs Q426122.
- Atacicept sameAs Q426122.
- Atacicept wasDerivedFrom Atacicept?oldid=659798506.
- Atacicept isPrimaryTopicOf Atacicept.