Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Apoptosome> ?p ?o }
- Apoptosome abstract "The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental cues such as those leading to the degradation of a tadpole's tail.In mammalian cells, once cytochrome c is released, it binds to the cytosolic protein Apaf-1 to facilitate the formation of apoptosome. An early biochemical study suggests a two-to-one ratio of cytochrome c to apaf-1 for apoptosome formation. However, recent structural studies suggest the cytochrome c to apaf-1 ratio is one-to-one. It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. The mammalian apoptosome had never been crystallized, but a human APAF-1/cytochrome-c apoptosome has been imaged at lower (2 nm) resolution by cryogenic transmission electron microscopy 10 years ago, revealing a wheel-like particle with 7-fold symmetry. Recently, a medium resolution (9.5 Ångström) structure of human apoptosome was also solved by cryo-electron microscopy, which allows unambiguous inference for positions of all the APAF-1 domains (CARD, NBARC and WD40) and cytochrome c. There is also now a crystal structure of the monomeric, inactive Apaf-1 subunit (PDB 3SFZ). Once formed, the apoptosome can then recruit and activate the inactive pro-caspase-9. Once activated, this initiator caspase can then activate effector caspases and trigger a cascade of events leading to apoptosis.".
- Apoptosome thumbnail Hapop.jpg?width=300.
- Apoptosome wikiPageID "3736715".
- Apoptosome wikiPageLength "27627".
- Apoptosome wikiPageOutDegree "104".
- Apoptosome wikiPageRevisionID "660812463".
- Apoptosome wikiPageWikiLink AAA_protein.
- Apoptosome wikiPageWikiLink AAA_proteins.
- Apoptosome wikiPageWikiLink APAF1.
- Apoptosome wikiPageWikiLink ATPase.
- Apoptosome wikiPageWikiLink Adenine_nucleotide_translocator.
- Apoptosome wikiPageWikiLink Adenosine_triphosphate.
- Apoptosome wikiPageWikiLink Alzheimers.
- Apoptosome wikiPageWikiLink Alzheimers_disease.
- Apoptosome wikiPageWikiLink Apaf-1.
- Apoptosome wikiPageWikiLink Apoptosis.
- Apoptosome wikiPageWikiLink Bcl-2.
- Apoptosome wikiPageWikiLink Bcl-2-associated_X_protein.
- Apoptosome wikiPageWikiLink Bcl-2_homologous_antagonist_killer.
- Apoptosome wikiPageWikiLink Bcl-xL.
- Apoptosome wikiPageWikiLink C-terminus.
- Apoptosome wikiPageWikiLink CARD_domain.
- Apoptosome wikiPageWikiLink Caenorhabditis_elegans.
- Apoptosome wikiPageWikiLink Calcium.
- Apoptosome wikiPageWikiLink Caspase.
- Apoptosome wikiPageWikiLink Caspase-3.
- Apoptosome wikiPageWikiLink Caspase-9.
- Apoptosome wikiPageWikiLink Caspase_3.
- Apoptosome wikiPageWikiLink Catalysis.
- Apoptosome wikiPageWikiLink Category:Apoptosis.
- Apoptosome wikiPageWikiLink Category:Organelles.
- Apoptosome wikiPageWikiLink Category:Programmed_cell_death.
- Apoptosome wikiPageWikiLink Ciclosporin.
- Apoptosome wikiPageWikiLink Cryo-electron_microscopy.
- Apoptosome wikiPageWikiLink Cyclophilin.
- Apoptosome wikiPageWikiLink Cytochrome_c.
- Apoptosome wikiPageWikiLink Cytosol.
- Apoptosome wikiPageWikiLink DNA_damage.
- Apoptosome wikiPageWikiLink DNA_repair.
- Apoptosome wikiPageWikiLink Drosophila.
- Apoptosome wikiPageWikiLink Drosophilia.
- Apoptosome wikiPageWikiLink Enzyme.
- Apoptosome wikiPageWikiLink Enzyme_inhibitor.
- Apoptosome wikiPageWikiLink Heptamer.
- Apoptosome wikiPageWikiLink Heptameter.
- Apoptosome wikiPageWikiLink Huntingtons_disease.
- Apoptosome wikiPageWikiLink Hydrolysis.
- Apoptosome wikiPageWikiLink Inner_membrane.
- Apoptosome wikiPageWikiLink Intermembrane_space.
- Apoptosome wikiPageWikiLink Intrinsic_apoptosis.
- Apoptosome wikiPageWikiLink Ion.
- Apoptosome wikiPageWikiLink Leukemia.
- Apoptosome wikiPageWikiLink Mammal.
- Apoptosome wikiPageWikiLink Mass_spectrometry.
- Apoptosome wikiPageWikiLink Membrane_potential.
- Apoptosome wikiPageWikiLink Mitochondria.
- Apoptosome wikiPageWikiLink Mitochondrial_permeability_transition_pore.
- Apoptosome wikiPageWikiLink Mitochondrion.
- Apoptosome wikiPageWikiLink Monomer.
- Apoptosome wikiPageWikiLink N-terminus.
- Apoptosome wikiPageWikiLink Nanometer.
- Apoptosome wikiPageWikiLink Nanometre.
- Apoptosome wikiPageWikiLink Oligomer.
- Apoptosome wikiPageWikiLink Outer_mitochondrial_membrane.
- Apoptosome wikiPageWikiLink Ovarian_cancer.
- Apoptosome wikiPageWikiLink P53.
- Apoptosome wikiPageWikiLink Parkinsons.
- Apoptosome wikiPageWikiLink Parkinsons_disease.
- Apoptosome wikiPageWikiLink Protein.
- Apoptosome wikiPageWikiLink Protein_dimer.
- Apoptosome wikiPageWikiLink Semipermeable_membrane.
- Apoptosome wikiPageWikiLink Suppressor.
- Apoptosome wikiPageWikiLink Tadpole.
- Apoptosome wikiPageWikiLink Taurine.
- Apoptosome wikiPageWikiLink Ternary_complex.
- Apoptosome wikiPageWikiLink The_Proteolysis_Map.
- Apoptosome wikiPageWikiLink Transmission_electron_microscopy.
- Apoptosome wikiPageWikiLink Viral_disease.
- Apoptosome wikiPageWikiLink Viral_infection.
- Apoptosome wikiPageWikiLink Voltage-dependent_anion_channel.
- Apoptosome wikiPageWikiLink WD40_repeat.
- Apoptosome wikiPageWikiLink Zymogen.
- Apoptosome wikiPageWikiLink File:177-Apoptosomes_apoptosomes.png.
- Apoptosome wikiPageWikiLink File:Apop_atomic_model.jpg.
- Apoptosome wikiPageWikiLink File:Hapop.jpg.
- Apoptosome wikiPageWikiLinkText "Apoptosome".
- Apoptosome wikiPageWikiLinkText "apoptosome".
- Apoptosome hasPhotoCollection Apoptosome.
- Apoptosome wikiPageUsesTemplate Template:Reflist.
- Apoptosome wikiPageUsesTemplate Template:Use_dmy_dates.
- Apoptosome subject Category:Apoptosis.
- Apoptosome subject Category:Organelles.
- Apoptosome subject Category:Programmed_cell_death.
- Apoptosome hypernym Structure.
- Apoptosome type Building.
- Apoptosome type Process.
- Apoptosome comment "The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus.".
- Apoptosome label "Apoptosome".
- Apoptosome sameAs Apoptosoma.
- Apoptosome sameAs Apoptosome.