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- Ap180 abstract "AP180 is a protein that plays an important role in clathrin-mediated endocytosis of synaptic vesicles. It is capable of simultaneously binding both membrane lipids (via an ANTH domain) and clathrin and is therefore thought to recruit clathrin to the membrane of newly invaginating vesicles. In Drosophila melanogaster (fruit flies), deletion of the AP180 homologue, leads to enlarged but much fewer vesicles and an overall decrease in transmitter release. In D. melanogaster it was also shown that AP180 is also required for either recycling vesicle proteins and/or maintaining the distribution of both vesicle and synaptic proteins in the nerve terminal. A ubiquitous form of the protein in mammals, CALM, (Clathrin-assembly lymphoid myeloid leukaemia protein) is named after its association with myeloid and lymphoid leukemias where some translocations map to this gene. The C-terminus of AP180 is a powerful and specific inhibitor of clathrin-mediated endocytosis.More information is found on endocytosis.org.".
- Ap180 wikiPageExternalLink S0092-8674(01)00230-6.
- Ap180 wikiPageExternalLink S0896-6273(00)80664-9.
- Ap180 wikiPageExternalLink AP180.html.
- Ap180 wikiPageExternalLink pmidlookup?view=long&pmid=10397769.
- Ap180 wikiPageID "6881318".
- Ap180 wikiPageLength "3317".
- Ap180 wikiPageOutDegree "21".
- Ap180 wikiPageRevisionID "659014265".
- Ap180 wikiPageWikiLink ANTH_domain.
- Ap180 wikiPageWikiLink Amphiphysin.
- Ap180 wikiPageWikiLink Biological_membrane.
- Ap180 wikiPageWikiLink Category:Peripheral_membrane_proteins.
- Ap180 wikiPageWikiLink Chromosomal_translocation.
- Ap180 wikiPageWikiLink Clathrin.
- Ap180 wikiPageWikiLink Drosophila_melanogaster.
- Ap180 wikiPageWikiLink Endocytosis.
- Ap180 wikiPageWikiLink Epsin.
- Ap180 wikiPageWikiLink Gene.
- Ap180 wikiPageWikiLink Homology_(biology).
- Ap180 wikiPageWikiLink Invagination.
- Ap180 wikiPageWikiLink Leukemia.
- Ap180 wikiPageWikiLink Lipid.
- Ap180 wikiPageWikiLink Lymphoid_leukemia.
- Ap180 wikiPageWikiLink Mammal.
- Ap180 wikiPageWikiLink Myeloid_leukemia.
- Ap180 wikiPageWikiLink Neurotransmitter.
- Ap180 wikiPageWikiLink Protein.
- Ap180 wikiPageWikiLink Synaptic_vesicle.
- Ap180 wikiPageWikiLink Vesicle_(biology).
- Ap180 wikiPageWikiLink Vesicle_(biology_and_chemistry).
- Ap180 wikiPageWikiLinkText "Ap180".
- Ap180 hasPhotoCollection Ap180.
- Ap180 wikiPageUsesTemplate Template:Cite_journal.
- Ap180 subject Category:Peripheral_membrane_proteins.
- Ap180 hypernym Protein.
- Ap180 type Protein.
- Ap180 comment "AP180 is a protein that plays an important role in clathrin-mediated endocytosis of synaptic vesicles. It is capable of simultaneously binding both membrane lipids (via an ANTH domain) and clathrin and is therefore thought to recruit clathrin to the membrane of newly invaginating vesicles. In Drosophila melanogaster (fruit flies), deletion of the AP180 homologue, leads to enlarged but much fewer vesicles and an overall decrease in transmitter release. In D.".
- Ap180 label "Ap180".
- Ap180 sameAs m.0gv0wl.
- Ap180 sameAs Q4778851.
- Ap180 sameAs Q4778851.
- Ap180 wasDerivedFrom Ap180?oldid=659014265.
- Ap180 isPrimaryTopicOf Ap180.