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- Antineurosteroid abstract "An antineurosteroid, or more precisely, a neurosteroidogenesis inhibitor, is a drug that inhibits the endogenous production of neurosteroids. Neurosteroids include the excitatory neurosteroids pregnenolone sulfate, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S), and the inhibitory neurosteroids allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol, among others.Inhibitory neurosteroids are biosynthesized by the action of two enzymes, 5α-reductase and 3α-hydroxysteroid dehydrogenase (3α-HSD). These enzymes can be inhibited by 5α-reductase inhibitors such as finasteride and dutasteride and by inhibitors of 3α-HSD such as medroxyprogesterone acetate. Contrarily, 3α-HSD is induced by certain selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, fluvoxamine, sertraline, and paroxetine, as well as certain other antidepressants like venlafaxine and mirtazapine, and these antidepressants have been found to increase inhibitory neurosteroid levels. Inhibition of inhibitory neurosteroid biosynthesis by 5α-reductase inhibitors and 3α-HSD inhibitors has been associated with depression, anxiety, irritability, and sexual dysfunction, whereas enhancement of their biosynthesis has been implicated in the antidepressant and anxiolytic effects of some of the SSRIs.Inhibitors of cholesterol side-chain cleavage enzyme (P450scc), such as aminoglutethimide, danazol, and ketoconazole, may block production of all neurosteroids, both excitatory and inhibitory, while inhibitors of 17α-hydroxylase and 17,20-lyase, such as abiraterone acetate, may block production of excitatory neurosteroids. Antigonadotropins may also lower neurosteroid levels.The translocator protein (TSPO), also initially described as the peripheral benzodiazepine receptor, is a mitochondrial protein that is involved in neurosteroid biosynthesis. It is activated by certain benzodiazepines such as diazepam and midazolam, and via this action, inhibitory neurosteroid levels are increased. Selective TSPO activators, such as emapunil, are under investigation for clinical use as possible anxiolytics.Progesterone, which is the endogenous precursor to the inhibitory neurosteroids 5α-dihydroprogesterone and allopregnanolone, as well as, more distantly, THDOC, when administered exogenously, has been found to behave as a prodrug to these neurosteroids, with clinical signs of their action, such as sedation, readily evident in humans.Metyrapone, a reversible inhibitor of the enzyme steroid 11β-hydroxylase, may increase inhibitory neurosteroid levels.".
- Antineurosteroid wikiPageID "47510379".
- Antineurosteroid wikiPageLength "9336".
- Antineurosteroid wikiPageOutDegree "60".
- Antineurosteroid wikiPageRevisionID "680551068".
- Antineurosteroid wikiPageWikiLink 17,20-lyase.
- Antineurosteroid wikiPageWikiLink 17α-hydroxylase.
- Antineurosteroid wikiPageWikiLink 3-alpha-HSD.
- Antineurosteroid wikiPageWikiLink 3α-Androstanediol.
- Antineurosteroid wikiPageWikiLink 3α-androstanediol.
- Antineurosteroid wikiPageWikiLink 3α-hydroxysteroid_dehydrogenase.
- Antineurosteroid wikiPageWikiLink 5-alpha-reductase_inhibitor.
- Antineurosteroid wikiPageWikiLink 5-alpha_reductase.
- Antineurosteroid wikiPageWikiLink 5α-Dihydroprogesterone.
- Antineurosteroid wikiPageWikiLink 5α-dihydroprogesterone.
- Antineurosteroid wikiPageWikiLink 5α-reductase.
- Antineurosteroid wikiPageWikiLink 5α-reductase_inhibitor.
- Antineurosteroid wikiPageWikiLink Abiraterone_acetate.
- Antineurosteroid wikiPageWikiLink Allopregnanolone.
- Antineurosteroid wikiPageWikiLink Aminoglutethimide.
- Antineurosteroid wikiPageWikiLink Antidepressant.
- Antineurosteroid wikiPageWikiLink Antigonadotropin.
- Antineurosteroid wikiPageWikiLink Anxiety.
- Antineurosteroid wikiPageWikiLink Anxiolytic.
- Antineurosteroid wikiPageWikiLink Benzodiazepine.
- Antineurosteroid wikiPageWikiLink Biosynthesis.
- Antineurosteroid wikiPageWikiLink CYP17A1.
- Antineurosteroid wikiPageWikiLink Category:Neurosteroids.
- Antineurosteroid wikiPageWikiLink Cholesterol_side-chain_cleavage_enzyme.
- Antineurosteroid wikiPageWikiLink Danazol.
- Antineurosteroid wikiPageWikiLink Dehydroepiandrosterone.
- Antineurosteroid wikiPageWikiLink Dehydroepiandrosterone_sulfate.
- Antineurosteroid wikiPageWikiLink Depression_(mood).
- Antineurosteroid wikiPageWikiLink Diazepam.
- Antineurosteroid wikiPageWikiLink Drug.
- Antineurosteroid wikiPageWikiLink Dutasteride.
- Antineurosteroid wikiPageWikiLink Emapunil.
- Antineurosteroid wikiPageWikiLink Endogenous.
- Antineurosteroid wikiPageWikiLink Endogeny_(biology).
- Antineurosteroid wikiPageWikiLink Enzyme.
- Antineurosteroid wikiPageWikiLink Enzyme_inducer.
- Antineurosteroid wikiPageWikiLink Enzyme_inhibitor.
- Antineurosteroid wikiPageWikiLink Excitatory.
- Antineurosteroid wikiPageWikiLink Excitatory_postsynaptic_potential.
- Antineurosteroid wikiPageWikiLink Exogenous.
- Antineurosteroid wikiPageWikiLink Exogeny.
- Antineurosteroid wikiPageWikiLink Finasteride.
- Antineurosteroid wikiPageWikiLink Fluoxetine.
- Antineurosteroid wikiPageWikiLink Fluvoxamine.
- Antineurosteroid wikiPageWikiLink Inhibitory.
- Antineurosteroid wikiPageWikiLink Inhibitory_postsynaptic_potential.
- Antineurosteroid wikiPageWikiLink Irritability.
- Antineurosteroid wikiPageWikiLink Ketoconazole.
- Antineurosteroid wikiPageWikiLink Medroxyprogesterone_acetate.
- Antineurosteroid wikiPageWikiLink Metyrapone.
- Antineurosteroid wikiPageWikiLink Midazolam.
- Antineurosteroid wikiPageWikiLink Mirtazapine.
- Antineurosteroid wikiPageWikiLink Mitochondria.
- Antineurosteroid wikiPageWikiLink Mitochondrion.
- Antineurosteroid wikiPageWikiLink Neuroactive_steroid.
- Antineurosteroid wikiPageWikiLink Neurosteroid.
- Antineurosteroid wikiPageWikiLink Paroxetine.
- Antineurosteroid wikiPageWikiLink Precursor_(biochemistry).
- Antineurosteroid wikiPageWikiLink Precursor_(chemistry).
- Antineurosteroid wikiPageWikiLink Pregnenolone_sulfate.
- Antineurosteroid wikiPageWikiLink Prodrug.
- Antineurosteroid wikiPageWikiLink Progesterone.
- Antineurosteroid wikiPageWikiLink Protein.
- Antineurosteroid wikiPageWikiLink Reversible_inhibitor.
- Antineurosteroid wikiPageWikiLink Selective_serotonin_reuptake_inhibitor.
- Antineurosteroid wikiPageWikiLink Sertraline.
- Antineurosteroid wikiPageWikiLink Sexual_dysfunction.
- Antineurosteroid wikiPageWikiLink Steroid_11-beta-hydroxylase.
- Antineurosteroid wikiPageWikiLink Steroid_11β-hydroxylase.
- Antineurosteroid wikiPageWikiLink Tetrahydrodeoxycorticosterone.
- Antineurosteroid wikiPageWikiLink Translocator_protein.
- Antineurosteroid wikiPageWikiLink Venlafaxine.
- Antineurosteroid wikiPageWikiLinkText "Antineurosteroid".
- Antineurosteroid hasPhotoCollection Antineurosteroid.
- Antineurosteroid wikiPageUsesTemplate Template:Reflist.
- Antineurosteroid wikiPageUsesTemplate Template:Steroid_hormone_metabolism_modulators.
- Antineurosteroid subject Category:Neurosteroids.
- Antineurosteroid hypernym Drug.
- Antineurosteroid type Drug.
- Antineurosteroid comment "An antineurosteroid, or more precisely, a neurosteroidogenesis inhibitor, is a drug that inhibits the endogenous production of neurosteroids.".
- Antineurosteroid label "Antineurosteroid".
- Antineurosteroid wasDerivedFrom Antineurosteroid?oldid=680551068.
- Antineurosteroid isPrimaryTopicOf Antineurosteroid.