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- Anrep_effect abstract "The Anrep effect is an autoregulation method in which myocardial contractility increases with afterload. It was experimentally determined that increasing afterload caused a proportional linear increase in ventricular inotropy.This effect is found in denervated heart preparations, such as the Starling Preparation, and as such, represents an intrinsic autoregulation mechanism.The Anrep effect is named after Russian physiologist Gleb von Anrep, who described it in 1912.Functionally, the Anrep effect allows the heart to compensate for an increased end-systolic volume present and the decreased stroke volume that occurs when aortic blood pressure increases. Without the Anrep effect, an increase in aortic blood pressure would create a decrease in stroke volume that would compromise circulation to peripheral and visceral tissues.Sustained myocardial stretch activates tension dependent Na+/H+ exchangers, bringing Na+ ions into the sarcolemma.This increase in Na+ in the sarcolemma reduces the Na+ gradient exploited by sodium-calcium exchanger (NCX) and stops them from working effectively.Ca2+ ions accumulate inside the sarcolemma as a result and are uptaken by sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pumps.Calcium induced calcium release (CICR) from the sarcoplasmic reticulum is increased upon stimulation of the cardiac myocyte by an action potential.This leads to an increase in the force of contraction of the cardiac muscle to try and increase stroke volume and cardiac output to maintain tissue perfusion.".
- Anrep_effect wikiPageID "11634601".
- Anrep_effect wikiPageLength "2346".
- Anrep_effect wikiPageOutDegree "9".
- Anrep_effect wikiPageRevisionID "678407609".
- Anrep_effect wikiPageWikiLink Afterload.
- Anrep_effect wikiPageWikiLink Blood_pressure.
- Anrep_effect wikiPageWikiLink Cardiac_muscle.
- Anrep_effect wikiPageWikiLink Category:Cardiology.
- Anrep_effect wikiPageWikiLink Contractility.
- Anrep_effect wikiPageWikiLink Heart.
- Anrep_effect wikiPageWikiLink Myocardial.
- Anrep_effect wikiPageWikiLink SERCA.
- Anrep_effect wikiPageWikiLink Sodium-calcium_exchanger.
- Anrep_effect wikiPageWikiLink Ventricle_(heart).
- Anrep_effect wikiPageWikiLinkText "Anrep effect".
- Anrep_effect wikiPageWikiLinkText "Gleb von Anrep".
- Anrep_effect hasPhotoCollection Anrep_effect.
- Anrep_effect wikiPageUsesTemplate Template:Circulatory-stub.
- Anrep_effect wikiPageUsesTemplate Template:Reflist.
- Anrep_effect subject Category:Cardiology.
- Anrep_effect hypernym Method.
- Anrep_effect type Software.
- Anrep_effect type Specialty.
- Anrep_effect comment "The Anrep effect is an autoregulation method in which myocardial contractility increases with afterload.".
- Anrep_effect label "Anrep effect".
- Anrep_effect sameAs أثر_أنريب.
- Anrep_effect sameAs Efekt_Anrepa.
- Anrep_effect sameAs m.02rm84t.
- Anrep_effect sameAs Q4770475.
- Anrep_effect sameAs Q4770475.
- Anrep_effect wasDerivedFrom Anrep_effect?oldid=678407609.
- Anrep_effect isPrimaryTopicOf Anrep_effect.