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- Anfinsens_dogma abstract "Anfinsen's dogma (also known as the thermodynamic hypothesis) is a postulate in molecular biology that, at least for small globular proteins, the native structure is determined only by the protein's amino acid sequence. The dogma was championed by the Nobel Prize Laureate (see [1]) Christian B. Anfinsen from his research on the folding of ribonuclease A. The postulate amounts to saying that, at the environmental conditions (temperature, solvent concentration and composition, etc.) at which folding occurs, the native structure is a unique, stable and kinetically accessible minimum of the free energy.The three conditions:Uniqueness: requires that the sequence does not have any other configuration with a comparable free energy. Hence the free energy minimum must be unchallenged.Stability: small changes in the surrounding environment cannot give rise to changes in the minimum configuration. This can be pictured as a free energy surface that looks more like a funnel (with the native state in the bottom of it) rather than like a soup plate (with several closely related low-energy states); the free energy surface around the native state must be rather steep and high, in order to provide stability.Kinetical accessibility: means that the path in the free energy surface from the unfolded to the folded state must be reasonably smooth or, in other words, that the folding of the chain must not involve highly complex changes in the shape (like knots or other high order conformations).How the protein reaches this structure is the subject of the field of protein folding, which has a related concept called Levinthal's paradox. The Levinthal paradox states that the number of possible conformations available to a given protein is astronomically large, such that even a small protein of 100 residues would require more time than the universe has existed (1026 seconds) to explore all possible conformations and choose the appropriate one, it would also arguably make computational prediction of protein structures under the same basis unfeasible if not impossible.Also, some proteins need the assistance of another protein called a chaperone protein to fold properly. It has been suggested that this disproves Anfinsen's dogma. However, the chaperones do not appear to affect the final state of the protein; they seem to work primarily by preventing aggregation of several protein molecules before the protein is folded.Prions are an exception to Anfinsen's dogma. Prions are stable conformations of proteins which differ from the native folding state. In Bovine spongiform encephalopathy (Mad Cow Disease), native proteins re-fold into a different stable conformation, which causes fatal amyloid buildup. Other amyloid diseases, including Alzheimer's disease and Parkinson's disease, are also exceptions to Anfinsen's dogma.The scientific approach behind POEM@HOME, a project using the BOINC distributed computing platform, uses elements of the thermodynamic hypothesis for its computations regarding research on protein structures.".
- Anfinsens_dogma thumbnail RibonucleaseA_SS_paleRib.png?width=300.
- Anfinsens_dogma wikiPageExternalLink chron.
- Anfinsens_dogma wikiPageExternalLink press.html.
- Anfinsens_dogma wikiPageID "7973428".
- Anfinsens_dogma wikiPageLength "5533".
- Anfinsens_dogma wikiPageOutDegree "22".
- Anfinsens_dogma wikiPageRevisionID "681409692".
- Anfinsens_dogma wikiPageWikiLink Alzheimers_disease.
- Anfinsens_dogma wikiPageWikiLink Amino_acid.
- Anfinsens_dogma wikiPageWikiLink Amyloid.
- Anfinsens_dogma wikiPageWikiLink Berkeley_Open_Infrastructure_for_Network_Computing.
- Anfinsens_dogma wikiPageWikiLink Biomolecular_structure.
- Anfinsens_dogma wikiPageWikiLink Bovine_spongiform_encephalopathy.
- Anfinsens_dogma wikiPageWikiLink Category:Hypotheses.
- Anfinsens_dogma wikiPageWikiLink Category:Molecular_biology.
- Anfinsens_dogma wikiPageWikiLink Category:Protein_structure.
- Anfinsens_dogma wikiPageWikiLink Chaperone_(protein).
- Anfinsens_dogma wikiPageWikiLink Christian_B._Anfinsen.
- Anfinsens_dogma wikiPageWikiLink Edgar_Haber.
- Anfinsens_dogma wikiPageWikiLink Levinthals_paradox.
- Anfinsens_dogma wikiPageWikiLink List_of_Nobel_laureates.
- Anfinsens_dogma wikiPageWikiLink Molecular_biology.
- Anfinsens_dogma wikiPageWikiLink POEM@Home.
- Anfinsens_dogma wikiPageWikiLink Parkinsons_disease.
- Anfinsens_dogma wikiPageWikiLink Primary_structure.
- Anfinsens_dogma wikiPageWikiLink Prion.
- Anfinsens_dogma wikiPageWikiLink Protein_aggregation.
- Anfinsens_dogma wikiPageWikiLink Protein_folding.
- Anfinsens_dogma wikiPageWikiLink Protein_structure.
- Anfinsens_dogma wikiPageWikiLink File:RibonucleaseA_SS_paleRib.png.
- Anfinsens_dogma wikiPageWikiLinkText "Anfinsen's dogma".
- Anfinsens_dogma wikiPageWikiLinkText "postulate".
- Anfinsens_dogma wikiPageWikiLinkText "proteins fold spontaneously".
- Anfinsens_dogma wikiPageWikiLinkText "thermodynamic hypothesis".
- Anfinsens_dogma hasPhotoCollection Anfinsens_dogma.
- Anfinsens_dogma wikiPageUsesTemplate Template:Cite_journal.
- Anfinsens_dogma subject Category:Hypotheses.
- Anfinsens_dogma subject Category:Molecular_biology.
- Anfinsens_dogma subject Category:Protein_structure.
- Anfinsens_dogma hypernym Postulate.
- Anfinsens_dogma comment "Anfinsen's dogma (also known as the thermodynamic hypothesis) is a postulate in molecular biology that, at least for small globular proteins, the native structure is determined only by the protein's amino acid sequence. The dogma was championed by the Nobel Prize Laureate (see [1]) Christian B. Anfinsen from his research on the folding of ribonuclease A.".
- Anfinsens_dogma label "Anfinsen's dogma".
- Anfinsens_dogma sameAs Anfinsen-Dogma.
- Anfinsens_dogma sameAs Dogma_de_Anfinsen.
- Anfinsens_dogma sameAs הדוגמה_של_אנפינסן.
- Anfinsens_dogma sameAs Dogma_di_Anfinsen.
- Anfinsens_dogma sameAs m.026m0qf.
- Anfinsens_dogma sameAs Анфинсенова_хипотеза.
- Anfinsens_dogma sameAs Anfinsens_dogma.
- Anfinsens_dogma sameAs Анфинсенова_хипотеза.
- Anfinsens_dogma sameAs Q2117425.
- Anfinsens_dogma sameAs Q2117425.
- Anfinsens_dogma wasDerivedFrom Anfinsens_dogmaoldid=681409692.
- Anfinsens_dogma depiction RibonucleaseA_SS_paleRib.png.
- Anfinsens_dogma isPrimaryTopicOf Anfinsens_dogma.