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- Amphiphysin abstract "Amphiphysin is a protein that in humans is encoded by the AMPH gene.This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff person syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.Amphiphysin is a brain-enriched protein with an N-terminal lipid interaction, dimerisation and membrane bending BAR domain, a middle clathrin and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of dynamin to sites of clathrin-mediated endocytosis. There are 2 mammalian amphiphysins with similar overall structure. A ubiquitous splice form of amphiphysin 2 that does not contain clathrin or adaptor interactions is highly expressed in muscle tissue and is involved in the formation and stabilization of the T-tubule network. In other tissues amphiphysin is likely involved in other membrane bending and curvature stabilization events.".
- Amphiphysin entrezgene "273".
- Amphiphysin wikiPageExternalLink amphiphysin.html.
- Amphiphysin wikiPageExternalLink pmidlookup?view=long&pmid=11711432.
- Amphiphysin wikiPageExternalLink pmidlookup?view=long&pmid=14645856.
- Amphiphysin wikiPageID "7075448".
- Amphiphysin wikiPageLength "18107".
- Amphiphysin wikiPageOutDegree "21".
- Amphiphysin wikiPageRevisionID "681994130".
- Amphiphysin wikiPageWikiLink AP180.
- Amphiphysin wikiPageWikiLink Ap180.
- Amphiphysin wikiPageWikiLink BAR_domain.
- Amphiphysin wikiPageWikiLink Biological_tissue.
- Amphiphysin wikiPageWikiLink CABIN1.
- Amphiphysin wikiPageWikiLink CDK5R1.
- Amphiphysin wikiPageWikiLink Cell_membrane.
- Amphiphysin wikiPageWikiLink Clathrin.
- Amphiphysin wikiPageWikiLink DNM1.
- Amphiphysin wikiPageWikiLink Dynamin.
- Amphiphysin wikiPageWikiLink Endocytosis.
- Amphiphysin wikiPageWikiLink Epsin.
- Amphiphysin wikiPageWikiLink Gene.
- Amphiphysin wikiPageWikiLink Lipid.
- Amphiphysin wikiPageWikiLink Muscle.
- Amphiphysin wikiPageWikiLink PLD2.
- Amphiphysin wikiPageWikiLink Phospholipase_D1.
- Amphiphysin wikiPageWikiLink Protein.
- Amphiphysin wikiPageWikiLink Protein-protein_interaction.
- Amphiphysin wikiPageWikiLink Protein–protein_interaction.
- Amphiphysin wikiPageWikiLink SH3GL2.
- Amphiphysin wikiPageWikiLink Stiff_person_syndrome.
- Amphiphysin wikiPageWikiLink Tissue_(biology).
- Amphiphysin wikiPageWikiLinkText "AMPH".
- Amphiphysin wikiPageWikiLinkText "Amphiphysin".
- Amphiphysin wikiPageWikiLinkText "amphiphysin".
- Amphiphysin hasPhotoCollection Amphiphysin.
- Amphiphysin requireManualInspection "no".
- Amphiphysin summaryText "This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff person syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.".
- Amphiphysin updateCitations "yes".
- Amphiphysin updatePage "yes".
- Amphiphysin updateProteinBox "yes".
- Amphiphysin updateSummary "yes".
- Amphiphysin wikiPageUsesTemplate Template:Cite_journal.
- Amphiphysin wikiPageUsesTemplate Template:PBB.
- Amphiphysin wikiPageUsesTemplate Template:PBB_Controls.
- Amphiphysin wikiPageUsesTemplate Template:PBB_Further_reading.
- Amphiphysin wikiPageUsesTemplate Template:PBB_Summary.
- Amphiphysin wikiPageUsesTemplate Template:Refbegin.
- Amphiphysin wikiPageUsesTemplate Template:Refend.
- Amphiphysin wikiPageUsesTemplate Template:Reflist.
- Amphiphysin hypernym Protein.
- Amphiphysin type Article.
- Amphiphysin type Biomolecule.
- Amphiphysin type Protein.
- Amphiphysin type Article.
- Amphiphysin type Thing.
- Amphiphysin type Q206229.
- Amphiphysin type Q8054.
- Amphiphysin comment "Amphiphysin is a protein that in humans is encoded by the AMPH gene.This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff person syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms.".
- Amphiphysin label "Amphiphysin".
- Amphiphysin sameAs m.0h2_jg.
- Amphiphysin sameAs Амфифизин.
- Amphiphysin sameAs Amfifizin.
- Amphiphysin sameAs Amfifizin.
- Amphiphysin sameAs Q4748325.
- Amphiphysin sameAs Q4748325.
- Amphiphysin wasDerivedFrom Amphiphysin?oldid=681994130.
- Amphiphysin isPrimaryTopicOf Amphiphysin.